DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and Orc1

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_808792.1	Gene:	Orc1 / 313479	RGDID:	631435	Length:	848	Species:	Rattus norvegicus

Alignment Length:	990	Identity:	334/990 - (33%)
Similarity:	496/990 - (50%)	Gaps:	217/990 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VNKENARSVGQQVKWIGSQDELPPVKNLEHKNVYFYQK----CI----YGPLTLSVGDFILVSNA 58
            |.::..|   |...|:|.     |:.|.:.    |||.    |:    ...:.:.||.|:|:...
  Rat     5 VTRQKTR---QTFSWVGR-----PLPNRKQ----FYQMYKEICMKINGCSEIHIKVGQFVLIQGE 57

  Fly    59 DAAEPDTVSGCDVARILHMYEL-RELTDREPCRAIVQWYSWPKAIPHNK---------------Y 107
            |..:|      .||:::.::|. .|:..::..|  |||:.....||..|               |
  Rat    58 DNQKP------YVAKLIELFENGSEVPPKKYAR--VQWFVRFCEIPIPKRHLLGRRPSAQEIFWY 114

  Fly   108 DDDEVAIDFSLEVIEEHRPYDNDVALGAIYRKCIVLEGTSKTS--AEEILKRHANKLKSTACPMF 170
            |..:...|..:|.|           :|.:....:..|.....:  :||.|
  Rat   115 DCSDCDNDIHVETI-----------IGPVQVVALAPEDEIPVNQKSEETL--------------- 153

  Fly   171 VSRYRFVKV---KRSYRLIPLEIHLEQPEDNARPTR-SSRKSLTAHRESKRSISARHDDTAGNKG 231
                 |||:   |:::..:|       ||:.|...| ..:|.|.|..:|.:|.|          .
  Rat   154 -----FVKLSWNKKNFAPLP-------PEELAALRRLECQKPLEAKTKSVKSPS----------W 196

  Fly   232 SSVEKR-RRASMAASSSVEFIDVNSFICENKVSPIKIVGG---RSVVRLSEKKNAPEINANYLPA 292
            |:.|:. :|...:.|:|..:.|....:..|.:..:: .||   :..:|||.|.....:::.
  Rat   197 STAEQEVKRIESSHSTSRSYQDPAHTVTPNAMKSLE-CGGFTRKPNMRLSRKILCDSLDSQ---- 256

  Fly   293 SPLTEKNAKVETPKSRASAARRNLNLSLDRGADTTADSDCLNYSIVQQTPDPKTPS-NDMKIKLR 356
                      :|.|.||:.:                          :.|..||.|. .::|....
  Rat   257 ----------KTCKRRAAFS--------------------------ETTSPPKKPQPGEIKTSSA 285

  Fly   357 LSERRRS---------------VRLASMDVDPLSLEEAVQEPNAQGRKRLGVANGDIYHTPT--- 403
            |....::               .|..::....|::|.|:..  .:.|.|..|| ..:..||.
  Rat   286 LETLGKNGHTQPFFAKSSMVLRTRGTAVKTTKLTVESALSP--VRSRSRYSVA-PSVGLTPQYIG 347

  Fly   404 KKSKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRS--IHLSNIVEQR-VFEDDEIISTPK 465
            :|:||           ..|.::.|..|..:|      |||  :.|..|.:|. :.:||:.....:
  Rat   348 RKAKE-----------QETHKEPIHTSLRAR------RRSSLLTLKRIKQQLWLLDDDKSDQEEE 395

  Fly   466 RGRSKKTVQDN---DEDYSPKKSVQKTPT-------RTRRSSTTTKTATTPSKGITTATATPMTP 520
            ...|...|.|:   :||    :||...||       ||||:: :..::.||||. ...|..|..|
  Rat   396 ESISSVEVSDSSSEEED----ESVPSPPTGKPVGQSRTRRTA-SKPSSQTPSKS-PKKTFRPRPP 454

  Fly   521 SQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYAFLEGK 585
            .....:||...|  ::|:    ||     |.|:.||.:||||.||.||||||:||::||:|:|.|
  Rat   455 LHATPQIRDRNL--AVQE----PA-----SVLEEARLRLHVSAVPDSLPCREQEFQDIYSFVESK 508

  Fly   586 IQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQ 650
            :.|..|||||:||||||||||||..|||.||:.|:.|::|.|||:|:|||:||||.|.||||.::
  Rat   509 LLDGTGGCMYISGVPGTGKTATVHEVIRCLQQAAQTNDVPPFEYVEVNGMKLTEPHQVYVQILQK 573

  Fly   651 LTGKTVSWEQAHALLEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVT 715
            |||:..:...|..||.|:|.:...::.||||||||||:|...:|||:|||.||||...|:|||:|
  Rat   574 LTGQKATANHAAELLAKQFCSRGSQKETTVLLVDELDLLWTHKQDVLYNLFDWPTHKGARLVVLT 638

  Fly   716 IANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEAVQLVARKVAAVS 780
            ||||||||||::|.:|.|||||||::||||||.||::|:.:||...:.|:.:|||||||||||:|
  Rat   639 IANTMDLPERIMMNRVASRLGLTRMSFQPYSHSQLKQILVSRLKHLKAFEDDAVQLVARKVAALS 703

  Fly   781 GDARRALDICRRATEIADTAAVK----C-VTMLHVQQALAEMIASAKVQAIRNCSRMEQIFLQAI 840
            |||||.||||||||||.:.:..:    | ||:.|:.:|:.||.:|:.:.||:|.|.:||.||:||
  Rat   704 GDARRCLDICRRATEICEVSHQRGDSQCLVTVAHLMEAIDEMFSSSYITAIKNSSVLEQSFLRAI 768

  Fly   841 AAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSRNDLFQKIL 905
            .||..|:|:||.||..:|.|...:....|:.:|.....:.:||:||:.|:::.|.|||||..::.
  Rat   769 IAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSRLGSCRILLVEPSRNDLLLRVR 833

  Fly   906 LNVSADDIHYALRVE 920
            ||||.:|:.|||:.|
  Rat   834 LNVSQNDVLYALKEE 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070	31/161 (19%)
		AAA	591..741	CDD:214640	94/149 (63%)
		AAA	594..739	CDD:278434	89/144 (62%)
		Cdc6_C	837..917	CDD:215013	32/79 (41%)
Orc1	NP_808792.1	BAH_Orc1p_animal	43..169	CDD:240070	28/147 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..227		11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..280		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..365		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..466		21/83 (25%)
		TIGR02928	482..814	CDD:274354	183/343 (53%)
		Necessary and sufficient for ORC complex assembly. /evidence=ECO:0000250	488..848		198/371 (53%)
		AAA_16	491..>541	CDD:289934	16/56 (29%)
		P-loop_NTPase	517..662	CDD:304359	77/144 (53%)
		Cdc6_C	765..838	CDD:286205	41/77 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340762
Domainoid	1	1.000	181	1.000	Domainoid score	I3396
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1743
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D427050at33208
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	1	1.000	-	-		oto97497
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	1	1.100	-	-	LDO	PTHR10763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760