DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and orc1

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_596060.1	Gene:	orc1 / 2540470	PomBaseID:	SPBC29A10.15	Length:	707	Species:	Schizosaccharomyces pombe

Alignment Length:	568	Identity:	208/568 - (36%)
Similarity:	297/568 - (52%)	Gaps:	87/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 RLGVANGDIYHTPTKKSKEPLE--------------SAAATEQTPSTRRKSILKSATSRLAEGTP 440
            |.||      |....|..|||:              .....|....|::||     .|| ..|.|
pombe   179 RRGV------HLKVNKYTEPLDWSYYAHNLERIEDLLVEMEENLRPTKKKS-----GSR-GRGRP 231

  Fly   441 RRSIHLSNIVEQRVFEDDEIISTPKRGRSKKTVQDNDEDYSPKKSVQ-KTPTRTRRSS--TTTKT 502
            |: ..|.|:      |..|..|..........:||:.|......::| :||.|..:.|  .::..
pombe   232 RK-YPLPNV------ESKESSSKVNSKDENFDLQDDSESSEDNLTIQPQTPRRRHKRSRHNSSNL 289

  Fly   503 ATTPSKGITTATATPMTPSQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQ-----LAREQLHVS 562
            |:||.                    |.|...|  .|.|.||.:..|..|.|     .||..|||:
pombe   290 ASTPK--------------------RNGYKQP--LQITPLPIRMLSLEEFQGSPHRKARAMLHVA 332

  Fly   563 VVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAF 627
            .||.:|.||:.||..|::.||..|:::.|.|:|:||.|||||||||..||..||.::::.:||.|
pombe   333 SVPSTLQCRDNEFSTIFSNLESAIEEETGACLYISGTPGTGKTATVHEVIWNLQELSREGQLPEF 397

  Fly   628 EYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAHALLEKRFTTPAPRRVTTVLLVDELDILCNR 692
            .:.||||||:|...|||..:::.|||:.|:...|..||:.|||..:|.|.:.|:|:||||.|...
pombe   398 SFCEINGMRVTSANQAYSILWESLTGERVTPIHAMDLLDNRFTHASPNRSSCVVLMDELDQLVTH 462

  Fly   693 RQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTAR 757
            .|.|:||..:||:...::|:||.:|||||||||:|..:::|||||:|:.|:||:|.||:.|:.||
pombe   463 NQKVLYNFFNWPSLPHSRLIVVAVANTMDLPERILSNRISSRLGLSRVPFEPYTHTQLEIIIAAR 527

  Fly   758 LGG---SETFKGEAVQLVARKVAAVSGDARRALDICRRATEIADTAAVKCVTMLHVQQALAEMIA 819
            |..   .:.|..:|::..|||||||||||||||||||||:|:|:....| ||...:.||::||.|
pombe   528 LEAVRDDDVFSSDAIRFAARKVAAVSGDARRALDICRRASELAENKNGK-VTPGLIHQAISEMTA 591

  Fly   820 SAKVQAIRNCSRMEQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRA------ 878
            |...:.:||.|.|:::||.||...:.|:|..|:.   ||:.:|.....:.|...|...|
pombe   592 SPLQKVLRNLSFMQKVFLCAIVNRMRRSGFAESY---VYEVLEEAERLLRVMTTPDAEAKFGELI 653

  Fly   879 LR------LCSKLGAERLIISEH--SRNDLFQKILLNVSADDIHYALR 918
            ||      :.|.|....::..|:  |||   .::.|.::.|:|..|.|
pombe   654 LRRPEFGYVLSSLSENGVLYLENKSSRN---ARVRLAIADDEIKLAFR 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		AAA	591..741	CDD:214640	75/149 (50%)
		AAA	594..739	CDD:278434	72/144 (50%)
		Cdc6_C	837..917	CDD:215013	23/93 (25%)
orc1	NP_596060.1	BAH_Orc1p_like	34..193	CDD:240066	6/19 (32%)
		CDC6	334..699	CDD:224391	160/372 (43%)
		AAA	364..509	CDD:278434	72/144 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	147	1.000	Domainoid score	I1124
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	1	1.000	-	-		oto101468
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	1	1.100	-	-	LDO	PTHR10763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	1	1.000	-	-		X2463
TreeFam	1	0.960	-	-
	11	10.800