DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and cdc18

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_595910.1	Gene:	cdc18 / 2540013	PomBaseID:	SPBC14C8.07c	Length:	577	Species:	Schizosaccharomyces pombe

Alignment Length:	548	Identity:	136/548 - (24%)
Similarity:	230/548 - (41%)	Gaps:	114/548 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 HTPTKKSKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRSIHLSNIVEQRVFEDDEIISTP 464
            ||| ::....::|||..:.|..|.::           |.:|..||              ||.:||
pombe     9 HTP-RRCNRFIDSAALIDCTNKTNQR-----------EHSPSFSI--------------EIPTTP 47

  Fly   465 KRGRSKKT----------------VQDNDEDYSPKKSVQKTPTRTRRSSTTTKTATTPSKGITTA 513
            .|.|:..:                :|:...|..|....|....:..:..||.:|..||.:  |..
pombe    48 SRKRTLASSHFQTPTKRIKYELGELQEEKTDLYPNFPAQLKENKKPKLPTTPQTPKTPKR--TIQ 110

  Fly   514 TATPMTPSQKMKKI----RAGELSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCRERE 574
            ..||.:.::....:    |..:.:|..|.....|:..|:.|....|:..|..|.....:..||.|
pombe   111 IVTPKSLNRTCNPVPFATRLLQSTPHRQLFPPTPSTPSTPSYNSTAKLSLRKSYRSAGVVGRENE 175

  Fly   575 FENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTE 639
            ...:.:|....:....||.:||||.||||||..:..|:..:     .::.|......||.|.:.|
pombe   176 KSIVESFFRQHLDANAGGALYVSGAPGTGKTVLLHNVLDHV-----VSDYPKVNVCYINCMTINE 235

  Fly   640 PRQAYVQIYKQLTGKTVSWEQAHAL-----LEKRFTTPAPRRVTTVLLV-DELDILCNRRQDVVY 698
            |:..:.:|:.::..:.:...:.|.:     ||..||..|......|::| ||:|.|..|.|.|:|
pombe   236 PKAIFEKIHSKIVKEEILENEDHHINFQCELESHFTQSANELYNPVIIVLDEMDHLIAREQQVLY 300

  Fly   699 NLLDWPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSET 763
            .|.:||::..::|::|.|||.:|:.:|.|....|..:....|:|.||:.:::..|:.|||..:.|
pombe   301 TLFEWPSRPTSRLILVGIANALDMTDRFLPRLRTKHITPKLLSFTPYTAQEISTIIKARLKTAAT 365

  Fly   764 FKGE----------------------------------AVQLVARKVAAVSGDARRALDICRRAT 794
            ...:                                  |::|.||||||.|||.|:||||||.|.
pombe   366 TSEKNNPFTPIKSISEVSDDSINVVSQHADETPFIHPAAIELCARKVAASSGDLRKALDICRHAI 430

  Fly   795 EIAD------------TAAVKCVTMLHVQQALAEMIASAKVQAIRNCSRMEQIFLQAIAAEVTRT 847
            |:|:            :..:...::.||.:|.:.|..||.       :|::.:.||..|...|..
pombe   431 ELAEREWKAQHDNTLSSVDIPRASIAHVVRATSAMSQSAS-------ARLKNLGLQQKAILCTLV 488

  Fly   848 GVEETTF--MGVYQQVETIAAFMGVTFP 873
            ..|:|:.  ..|:::..::.....:.:|
pombe   489 VCEKTSLSVADVFEKYSSLCLRDRLIYP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		AAA	591..741	CDD:214640	48/155 (31%)
		AAA	594..739	CDD:278434	46/150 (31%)
		Cdc6_C	837..917	CDD:215013	8/39 (21%)
cdc18	NP_595910.1	CDC6	169..571	CDD:224391	97/360 (27%)
		AAA	170..333	CDD:99707	51/167 (31%)
		Cdc6_C	478..560	CDD:176573	8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740