Protein Alignment Orc1 and Cdc6

DIOPT Version :9

• Sequence 1: NP_477303.1
• Gene: Orc1 / 35686
• FlyBaseID: FBgn0286788
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_035929.1
• Gene: Cdc6 / 23834
• MGIID: 1345150
• Length: 589
• Species: Mus musculus
• Alignment Length: 600
• Identity: 157/600 - (26%)
• Similarity: 260/600 - (43%)
• Gaps: 110/600 - (18%)

  Fly   388 RKRLGVANGDIYHTPTKKSKEPLESAAATEQTPSTRRKSILKSATSRLAE----------GTPRR 442
            |:..|:....:...|..:|:     ..||...|..:..:.||...||..|          .||..
Mouse    15 RQTSGIIQVCVAIMPQTRSQ-----TQATIGFPKKKLSNTLKKPNSRDCEVKLRNVQPVPTTPCV 74

  Fly   443 SIHLSNIVEQRVFEDDEIISTPKRGRSKKTVQDNDEDYSPKKSVQKT--PTRTRRSSTTTKTATT 505
            .:.|..:..::...||.:.:||:.           ...||.|..:|.  |.|    |.|.|....
Mouse    75 DVKLLPLSPRKRLGDDNLCNTPRL-----------SPCSPPKLGKKENGPPR----SHTWKGCRL 124

  Fly   506 PSKGITTATATPMTPSQKMK--KIRAGELSPSMQQRTD-----LPAKDS-----SKSE---LQLA 555
            ......|..|:|.....:::  :||:.....|.:.:.|     .|.|:|     .|.|   .|.|
Mouse   125 VFDDEPTFKASPPKEQDRVRQHQIRSSSAQRSPESKADPEQKCPPEKESVCIRLFKQEGTCYQQA 189

  Fly   556 REQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAK 620
            :..|: :.||..||.||:|...|..||:..|..:..|.:|:||.|||||||.::.:::..::
Mouse   190 KLVLN-TAVPDRLPAREQEMGVIRNFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKK--- 250

  Fly   621 QNELPAFEYLEINGMRLTEPRQAYVQIYKQL--------TGKTVSWEQAHALLEKRFTTPAPRRV 677
              |:..|:.:.:|.|.|...:..:..|.:::        .||.:..:     |||..|  |.:..
Mouse   251 --EVKGFKSILLNCMSLRSAQAVFPAIAQEIGREELCRPAGKDLMRK-----LEKHLT--AEKGP 306

  Fly   678 TTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTR--- 739
            ..||::||:|.|.::.|||:|.|.:||..|.::||::.||||:||.:|:|     .||....
Mouse   307 MIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRIL-----PRLEARENCK 366

  Fly   740 ---LTFQPYSHKQLQEIVTARLGGSETFKGE-----AVQLVARKVAAVSGDARRALDICRRATEI 796
               |.|.||:..|:..|:..||  |:..|.:     |:|..||||:|||||.|:|||:||||.||
Mouse   367 PQLLNFPPYTRNQIAAILQDRL--SQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEI 429

  Fly   797 --------------------ADTAAVKCVTMLHVQQALAEMIASAKVQAIRNCS----RMEQIFL 837
                                :::...|.|.:.|:.|.::|:..:....:..|..    ..::|.:
Mouse   430 VESDVRSQTVLKPLSECKSPSESPVPKRVGLAHISQVISEVDGNRVTLSQENTQDSLPLQQKILV 494

  Fly   838 QAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSRNDLFQ 902
            .::.....|..::|.|...:|:...:|.....||.......|.|...|.:..|:..:.::.....
Mouse   495 CSLLLLTRRLKIKEVTLGKLYEAYSSICRKQQVTAVDQSECLSLSGLLESRGLVGLKKNKESRLT 559

  Fly   903 KILLNVSADDIHYAL 917
            |:.|.:...:|.:.|
Mouse   560 KVSLKIEEKEIEHVL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		AAA	591..741	CDD:214640	50/163 (31%)
		AAA	594..739	CDD:278434	49/152 (32%)
		Cdc6_C	837..917	CDD:215013	14/79 (18%)
Cdc6	NP_035929.1	CDC6	197..574	CDD:224391	113/395 (29%)
		AAA_16	200..341	CDD:289934	47/152 (31%)
		Cdc6_C	494..574	CDD:215013	14/79 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D427050at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750