DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and Orc1

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_035145.2	Gene:	Orc1 / 18392	MGIID:	1328337	Length:	840	Species:	Mus musculus

Alignment Length:	978	Identity:	315/978 - (32%)
Similarity:	470/978 - (48%)	Gaps:	218/978 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QQVKWIGSQDELPPVKNLEHKNVYFYQKCIY----GPLTLSVGDFILVSNADAAEPDTVSGCDVA 72
            |...|:|.     |:.|.:.....:.:.|:.    ..:.:.||.|:|:...|..:|      .||
Mouse    12 QTFSWVGR-----PLPNRKQFQQMYREICMKINDGSEIHIKVGQFVLIQGEDNKKP------YVA 65

  Fly    73 RILHMYELRELTDREPCRAIVQWYSWPKAIPHNK---------------YD----DDEVAIDF-- 116
            :::.:::.......:.| |.|||:.....||.:|               ||    |:::.::.
Mouse    66 KLIELFQNGAEVPPKKC-ARVQWFVRFLEIPVSKRHLLGRSPPAQEIFWYDCSDWDNKINVETII 129

  Fly   117 -SLEVI----EEHRPYDNDVALGAIYRKCIVLEGTSKTSAEEILKRHANKLKSTACPMFVSRYRF 176
             .::|:    ||..|.|.                    .:||.|                    |
Mouse   130 GPVQVVALAPEEVIPVDQ--------------------KSEETL--------------------F 154

  Fly   177 VKV---KRSYRLIPLEIHLEQPEDNARPTRSSRKSLTAHRESKRSISARHDDTAGNKGSSVEKRR 238
            ||:   |:.:..:|.|:                  |.|.||.:
Mouse   155 VKLSWNKKDFAPLPPEV------------------LAALREQE---------------------- 179

  Fly   239 RASMAASSSVEFIDVNSFICENKVSPIKIVGGRSVVRLSEKKNAPEINANYLPASPLTEKNAKVE 303
                   .|.|:         .|....||...:|..|.:.::....|.:|: ..|...:..|.:.
Mouse   180 -------DSPEW---------QKPLKAKIKNVKSPARNTTEQEVKGIKSNH-STSKFHQTPANIV 227

  Fly   304 TPKSRASAARRNLNLSLDRGADTTADSDC--LNY--------SIVQQTPDPKTPSNDMKIKLRLS 358
            .|.::.|.....|..:.......:..|.|  |:|        :..:.|..||.|:...:||   .
Mouse   228 IPNAKKSLELDGLGFTRKPNTRWSKKSSCDSLDYQKTSKRRAAFSETTSPPKKPNKPREIK---P 289

  Fly   359 ERRRSVRLASMDVDPLSLEEAV----QEPNAQGRKRLGVANGDIYHTPTKKSKEPLESAAATEQT 419
            ......|:.:....|...:.:|    :.| |....:|||.|          :..|:.:...:...
Mouse   290 SSALETRVKNGQTQPFCAKSSVVLRARNP-AMTTTKLGVDN----------TLSPIRNGLRSSVV 343

  Fly   420 PS-------TRRKSILKSATSRLAEGTPRRSIHLSNIVEQRVFEDDEIISTPKRGRSKKTVQDND 477
            ||       .|||:             ..:..|...|...||.....:: |.||.|.:..:.|.|
Mouse   344 PSGGLTPVYIRRKA-------------KEQETHKEPIRTSRVHRKSSLL-TLKRIRQQLCLLDGD 394

  Fly   478 E-DYSPKKSVQK---------TPTRTRRSSTTTKTATTPSKGITTATATPMTPSQKMKKIRAGEL 532
            : |...::||..         :...||.|...::|..||||. ......|.||.:...:||...|
Mouse   395 DRDQEEEESVDSESEEEDEFISSLPTRNSLGQSRTRQTPSKS-PQKNPKPRTPHRATPQIRDRNL 458

  Fly   533 SPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVS 597
              ::|:    ||     |.|:.||.:||||.||.||||||:||::||:|:|.|:.|..|||||:|
Mouse   459 --AVQE----PA-----SALEEARLRLHVSAVPDSLPCREQEFQDIYSFVESKLLDGTGGCMYIS 512

  Fly   598 GVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAH 662
            |||||||||||..|||.||:.|:.:::|.|:|:|:|||:||||.|.||||.|:|||:..:...|.
Mouse   513 GVPGTGKTATVHEVIRCLQQAAETDDVPPFQYVEVNGMKLTEPHQVYVQILKKLTGQKATANHAA 577

  Fly   663 ALLEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLL 727
            .||.|:|.....::.||||||||||:|...:|||:|||.||||...|.|:|:|||||||||||::
Mouse   578 ELLAKQFCGQGSQKETTVLLVDELDLLWTHKQDVMYNLFDWPTHKGAHLIVLTIANTMDLPERIM 642

  Fly   728 MGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEAVQLVARKVAAVSGDARRALDICRR 792
            |.:|:|||||||::||||||.||::|:.:||.....|:.:|:|||||||||:||||||.||||||
Mouse   643 MNRVSSRLGLTRMSFQPYSHSQLKQILVSRLRNLRAFEDDAIQLVARKVAALSGDARRCLDICRR 707

  Fly   793 ATEIADTA-----AVKCVTMLHVQQALAEMIASAKVQAIRNCSRMEQIFLQAIAAEVTRTGVEET 852
            ||||.:.:     ::..||:.|:.:|:.||.:|:.:.||:|.|.:||.||:||.||..|:|:||.
Mouse   708 ATEICELSHLRGDSLSLVTVAHLMEAIDEMFSSSYITAIKNSSVVEQSFLRAIIAEFRRSGLEEA 772

  Fly   853 TFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSRNDLFQKILLNVSADDIHYAL 917
            ||..:|.|...:....|:.:|.....:.:||:||:.||::.|.|||||..::.||||.:|:.:||
Mouse   773 TFQQIYSQHVALCRMEGLPYPTMSETMAVCSRLGSCRLLLVEPSRNDLLLRVRLNVSQNDVLFAL 837

  Fly   918 RVE 920
            :.|
Mouse   838 KEE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070	31/169 (18%)
		AAA	591..741	CDD:214640	92/149 (62%)
		AAA	594..739	CDD:278434	87/144 (60%)
		Cdc6_C	837..917	CDD:215013	32/79 (41%)
Orc1	NP_035145.2	BAH	43..169	CDD:295389	27/151 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..218		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..301		10/58 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..456		13/70 (19%)
		TIGR02928	474..806	CDD:274354	176/346 (51%)
		Necessary and sufficient for ORC complex assembly. /evidence=ECO:0000250	480..840		188/373 (50%)
		AAA_16	483..>533	CDD:289934	15/58 (26%)
		P-loop_NTPase	509..654	CDD:304359	75/144 (52%)
		Cdc6_C	757..830	CDD:286205	39/77 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837044
Domainoid	1	1.000	178	1.000	Domainoid score	I3550
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1785
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	1	1.000	-	-		oto93966
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	1	1.100	-	-	LDO	PTHR10763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	1	1.000	-	-		X2463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780