Protein Alignment Orc1 and orc-1

DIOPT Version :10

• Sequence 1: NP_477303.1
• Gene: Orc1 / 35686
• FlyBaseID: FBgn0286788
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_499347.1
• Gene: orc-1 / 176486
• WormBaseID: WBGene00012650
• Length: 636
• Species: Caenorhabditis elegans
• Alignment Length: 675
• Identity: 193/675 - (28%)
• Similarity: 316/675 - (46%)
• Gaps: 112/675 - (16%)

  Fly   292 ASPLTEKNAKV-ETPKSRASAARRNLNLSLDRGA------------DTTADSDCLN-YSIVQQTP 342
            |:|:..::.:: ..|||.....:|: ::.| |||            .:::|||..: |:..:.
 Worm    14 ATPVKRRSTRITNLPKSAPKIVKRS-SVRL-RGAPQCTYKSDSSSSSSSSDSDGEDEYAATKD-- 74

  Fly   343 DPKTPSNDMKIKLRLSERRRSVRLASMDVDPLSLEEAVQEPNAQGRKRLGVANGDIYHTPTKKSK 407
            :.|...:|.::::..|             |.:. |...:|.:...::...|...   .|||:
 Worm    75 ELKAVDHDNQMEIDFS-------------DEIG-ENFSEEDSCSDKENRRVTRS---RTPTR--- 119

  Fly   408 EPLESAAATEQTPSTR------RKSILKSATSR--LAEGTPRRSIHLSNIVEQ-RVFEDDEIIST 463
                    .|:|||.|      :.|:.|.:||:  ..|....|.:.:|....: |||::::
 Worm   120 --------LEETPSKRLARELSKASVSKVSTSKTLFKESKSPRKVEISRKTNKARVFQEED---- 172

  Fly   464 PKRGRSKKTVQDNDEDYS---PKKSVQKTPTRTRRSSTTTKTATTPSKGITTATATPM----TPS 521
                      .|:::|:|   .:|...||..|      |..|...|||.| |...||:    ||.
 Worm   173 ----------DDDEDDFSDEIDEKFYSKTNKR------TPITIKIPSKMI-TQKVTPLVISKTPG 220

  Fly   522 QKMK-KIRAGELSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYAFLEGK 585
            ..:: :.||.:.|..::...| |....|.|.|:....:||:|.||:.||||:.|...|..|:...
 Worm   221 GTLRTRRRARQNSEELEDLVD-PLDSRSASTLKELASRLHLSKVPEKLPCRDIESREIEKFIREV 284

  Fly   586 IQDQCG--GCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIY 648
            |..:.|  ..||:||||||||||||..|:.:   |.|..:...|.|:|:|.|..  .:..:|:||
 Worm   285 IDPKRGESSAMYISGVPGTGKTATVRAVVNS---MKKSKKCQKFVYVEVNAMIF--KKTVFVEIY 344

  Fly   649 ----------KQLTGKTVSWEQAHALLEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDW 703
                      |:.....::...|...|...|....|:|...|:|:||||.||||:|||:|::.:|
 Worm   345 NGIQEEYNISKKPQRAKITATAARQELNSIFKREDPKRPPIVVLIDELDSLCNRKQDVLYDIFEW 409

  Fly   704 PTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEA 768
            .....:|:.::.||||:|.|||:|..:..|||...||.||||.|:|::|||.|||.||.....:|
 Worm   410 TALPQSKVTIIGIANTLDFPERMLCQRNASRLDKRRLVFQPYQHEQIEEIVRARLQGSNLIDPKA 474

  Fly   769 VQLVARKVAAVSGDARRALDICRRATEIADTAAVKCVTMLHVQQALAEMIASAKVQAIRNCSRME 833
            |:|||:|||..:||.|:|||...||..:|.....:.:.:.||..|...::...|.:.::.. |:.
 Worm   475 VELVAKKVAMNTGDLRQALDFLCRAIRVAVERKSEKLELSHVIAAQNAVLEPLKYRLVKGL-RLH 538

  Fly   834 QIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPP-----GRALRLCSKLGAERLIIS 893
            |..|......:||. .||..|..:|:....|.:.:....|..     |..|:|.|   ...:.:|
 Worm   539 QFTLFRTIESMTRE-QEEIIFANIYKNYCIICSEVSGIGPATDSFAYGMLLQLAS---TSLINLS 599

  Fly   894 EHSRNDLFQKILLNVSADDIHYALR 918
            :.....:.:::.|.:::.:...|::
 Worm   600 KGDHGMMNRRVKLGMTSMEAEKAIK 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		PTZ00112	<559..795	CDD:240274	105/247 (43%)
		Cdc6_C	837..917	CDD:215013	15/84 (18%)
orc-1	NP_499347.1	CDC6	263..627	CDD:441083	125/372 (34%)