DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and cdc-6

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_491343.1	Gene:	cdc-6 / 172029	WormBaseID:	WBGene00000382	Length:	518	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	139/553 - (25%)
Similarity:	237/553 - (42%)	Gaps:	152/553 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 RRRSVRLASMDVDPLSLEEAVQEPNAQGRKRLGVANGDIYHTPTKKSKEPLESAAATEQTPSTR- 423
            ||:|.||::..| |:   |..:.|:::..||:.|:. .::|       |.:||::..|..|.|:
Worm    30 RRKSSRLSTQSV-PI---EKKKTPSSKTTKRVPVSE-RVFH-------EEVESSSEDELLPQTKM 82

  Fly   424 ----RKSILKSATSRLAEGTPRRSIHLSNIVEQRVFEDDEIISTPKRGRSKKTVQDNDEDYSPKK 484
                ::.:|.|..|.||:               || |..||.|...|||.:|
Worm    83 ASEEKRKLLLSPGSSLAD---------------RV-EKLEISSPRARGRPRK------------- 118

  Fly   485 SVQKTPTRTRRSSTTTKTATTPSKGITTATATPMTPSQKMKKIRAGELSPSMQQRTDLPAKDSSK 549
                        :|..|:..|          ||.||.::.:.....:.:|..:.|.:..::..|:
Worm   119 ------------ATNLKSQLT----------TPRTPEKQSRSRSGSQGTPEKKSRKESSSESDSE 161

  Fly   550 SELQLAREQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRT 614
            ..:..:.|        .:|..|..||:::..::....:......:||||.||||||||...|:::
Worm   162 EIISTSSE--------GALKGRREEFDSLKLWIMKSKETNTSLSIYVSGQPGTGKTATTMRVLKS 218

  Fly   615 LQR--------MAKQNELPA-----FEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAHALLE 666
            |.:        .|..|...|     ||.|:::|    :|.:   :|:::           |.
Worm   219 LGKSVRSCIVNCASTNTKSALFKTIFESLDLDG----KPNE---EIFEK-----------HV--- 262

  Fly   667 KRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMGKV 731
            |:|.||      .||::||:|.|.||:...:|....||...:.|::::.|||::||.||||
Worm   263 KQFKTP------LVLVLDEIDHLANRKNAALYAAFQWPETLSRKIIILGIANSIDLTERLL---- 317

  Fly   732 TSRLGLT----RLTFQPYSHKQLQEIVTARLGGSET-FKGEAVQLVARKVAAVSGDARRALDICR 791
             .:|.|.    ||.|:||:...:.||:..::...|| ...:|::|.||||||:|||.|.||.|.:
Worm   318 -PKLMLAKPPKRLVFEPYTKDDIVEILNDKMKNEETSIDAKAIELTARKVAAMSGDLRTALHIFK 381

  Fly   792 RA--------TEIADTAAVKCVTMLHV-----QQALAE----------MIASAKVQAIRNCSRME 833
            :.        :::..|....|..:|.:     ...||.          :..|..:.|.:.|:...
Worm   382 QQKSRMIPDDSKVPGTPVNGCREVLGIINNVYSSPLARARLPLQPRILLAVSLTLSANKKCTFDR 446

  Fly   834 QIFLQAI--AAEVTR-TGVEETTFMGVYQQVET 863
            ...|:|.  |.|..| ..:::......:|.:|:
Worm   447 NSLLRAYYKACEALRMPALDDDELHSAFQTLES 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		AAA	591..741	CDD:214640	52/166 (31%)
		AAA	594..739	CDD:278434	51/161 (32%)
		Cdc6_C	837..917	CDD:215013	7/30 (23%)
cdc-6	NP_491343.1	AAA	197..335	CDD:214640	55/169 (33%)
cdc-6	NP_491343.1	AAA_22	197..>279	CDD:290137	33/108 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D427050at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750