Protein Alignment Orc1 and Orc1

DIOPT Version :10

• Sequence 1: NP_477303.1
• Gene: Orc1 / 35686
• FlyBaseID: FBgn0286788
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_315055.3
• Gene: Orc1 / 1275769
• VectorBaseID: AGAMI1_002946
• Length: 875
• Species: Anopheles gambiae
• Alignment Length: 958
• Identity: 440/958 - (45%)
• Similarity: 590/958 - (61%)
• Gaps: 129/958 - (13%)

  Fly     6 NARSVGQQVKWIGSQDELPPVKNLEHKNVYFYQKCIYGPLTLSVGDFILVSNADAAEPDTVSGCD 70
            |.......:.|:|.|.: |.|..::::...||.|||:|.|||.||:::|||:.||||||::.|||
Mosquito     7 NNNKFSSPITWVGKQYQ-PDVNCVKNRFAAFYSKCIFGALTLEVGNYVLVSDMDAAEPDSIDGCD 70

  Fly    71 VARILHMYEL--RELTDREPCRAIVQWYSWPKAIPHNKYDDDEVAIDFSLEVIEEHRPYDNDVAL 133
            ||||:||||:  .:.|:.:||||||:|||.|.|:|.....|:....| :.|||.:.| :..|:::
Mosquito    71 VARIVHMYEVLNSDCTNMDPCRAIVEWYSRPSALPKLITGDENYTFD-AREVIADSR-FSPDISI 133

  Fly   134 GAIYRKCIVLEGTSKTSAEEILKRHANKLKSTA-CPMFVSRYRFVKVK-RSY---RLIPL----- 188
            ..|:..|.|.....:|:..||     ..|||:: .|.|.:||:..|.. |.:   .|:|:
Mosquito   134 ETIFNLCWVEHVPLQTNLAEI-----QALKSSSRGPSFFARYKLEKASGRKWSLNALVPMVDATT 193

  Fly   189 ------------EIHLEQPEDNARPTRSSRKSLTAHRESKRSISARHDDTAGNKGSSVEKRRRAS 241
                        |..:|.|:     |...:.:.|...|:..|:|      ...|...:|.|
Mosquito   194 PRKRRSMYDLSNEPIIETPK-----TPKLKLTRTKSLENMPSLS------PNQKSKLIEDR---- 243

  Fly   242 MAASSSVEFIDVNSFICENKVSPIKIVGGRSVVRLSEKKN-APEINANYLPASPLTEKNAKVETP 305
                .:|:.|||...|.|       |....|.:.:|:.:| .|..|...|.....:..|.::. |
Mosquito   244 ----WAVKLIDVKQNIDE-------ITDILSEIEISDSENRRPPANQEKLQKVRRSSMNLRLH-P 296

  Fly   306 KSRASAARRNLNLSLDRGADTTADSDCLNYSIVQQTPDPKTPSNDMKIKLRLSERRRSVRLASMD 370
            |..|.|            :::..|.:|||||||:.  ...|....:||||||||.:::..
Mosquito   297 KPSAYA------------SNSGTDDECLNYSIVRD--GATTSERQIKIKLRLSENQKNTE----- 342

  Fly   371 VDPLSLEEAVQEPNAQGRKRLGVANGDIYH-TPTKKSKEPLESAAATEQTPSTR--RKSILKSAT 432
             .|.||           |||:..::....| :|.|..|..|.:...:..|||.|  ||||||:.:
Mosquito   343 -SPKSL-----------RKRVTSSSVPPEHVSPPKCRKSLLPADVESVSTPSGRSHRKSILKTPS 395

  Fly   433 SRLAE-GTPRRSIHLSNIVEQRVFEDDEIISTPKRGRSKKTVQDNDEDYSPKK------SVQKTP 490
            :..:: |||:|:|.||||:|:           ...||....:.    :.||||      ...|||
Mosquito   396 THASQVGTPKRNIQLSNIIEE-----------CSNGRRVSRLL----ELSPKKLEPLPIDEPKTP 445

  Fly   491 TRTRRSSTTTKTATTPSKGITTATATPMTPSQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQLA 555
            .|..|.|:.  .||.||   :.:..||.: :.|||.||.|.:.|::..| |.|.:|.: :||.:|
Mosquito   446 KRNSRLSSV--GATLPS---SASKGTPKS-ANKMKLIRDGTIKPNIHSR-DAPVQDGA-NELAVA 502

  Fly   556 REQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAK 620
            ||:||||..|.||||||:|:|.||.||||||.|.||||||:|||||||||||.|.|:|.|:.:::
Mosquito   503 RERLHVSATPSSLPCREKEYEEIYNFLEGKIFDGCGGCMYISGVPGTGKTATTTAVLRALKHLSE 567

  Fly   621 QNELPAFEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAHALLEKRFTTPAPRRVTTVLLVDE 685
            :.::|.||:::||||||||||||||.||:||||||::||||:.||.|||||.||||:||||||||
Mosquito   568 EEDIPKFEFVDINGMRLTEPRQAYVHIYRQLTGKTLAWEQAYNLLNKRFTTKAPRRITTVLLVDE 632

  Fly   686 LDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQL 750
            ||||||:|||||||||:|||...|:|:||||||||||||||||||::|||||||||||||:.:||
Mosquito   633 LDILCNKRQDVVYNLLNWPTMPTAQLIVVTIANTMDLPERLLMGKISSRLGLTRLTFQPYNFRQL 697

  Fly   751 QEIVTARLGGSETFKGEAVQLVARKVAAVSGDARRALDICRRATEIADTAAVK-----CVTMLHV 810
            ||||.|||.|...|..:||||||||||||||||||||||||||||:||..|.|     .|:|:||
Mosquito   698 QEIVMARLVGMSAFNSDAVQLVARKVAAVSGDARRALDICRRATELADDQARKSNESVTVSMMHV 762

  Fly   811 QQALAEMIASAKVQAIRNCSRMEQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPP 875
            ||||.|||.||||:.||:|||:||:||||:.|||||||:||..|:|||.|.|::|||.|:..|.|
Mosquito   763 QQALTEMITSAKVKTIRSCSRLEQLFLQAVTAEVTRTGIEECNFLGVYSQFESLAAFSGIIVPNP 827

  Fly   876 GRALRLCSKLGAERLIISEHSRNDLFQKILLNVSADDIHYALRVEEMV 923
            |||:.:|::|.|.||:|.|..::|::||||||:|.||:|:||:..:::
Mosquito   828 GRAMAICARLAASRLLICECGKSDIYQKILLNISTDDVHFALQASKLL 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070	60/147 (41%)
		PTZ00112	<559..795	CDD:240274	179/235 (76%)
		Cdc6_C	837..917	CDD:215013	45/79 (57%)
Orc1	XP_315055.3	None