DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-G and ENPP2

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_006716647.1	Gene:	ENPP2 / 5168	HGNCID:	3357	Length:	940	Species:	Homo sapiens

Alignment Length:	402	Identity:	74/402 - (18%)
Similarity:	117/402 - (29%)	Gaps:	159/402 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PPAYDSFVLLLVDALRDDFPDATS--MP-VAYSRAC--EKLKLHVDIPTVTMPRLKSITTGTLSN 119
            ||    .::..||..|..:....|  || :...|:|  ....:....||.|.|.|.::.||....
Human   164 PP----LIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPE 224

  Fly   120 FIDIALNVGHTEQMQDSFLHRLKQQNRVVSFAGDHTWVKLFPSEFTRQVENHDSFYVNDFYEGDR 184
            ...|..|..:......:|..|.:::.....:.|...|:..     |:|.....:|:.:.....:|
Human   225 SHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITA-----TKQGVKAGTFFWSVVIPHER 284

  Fly   185 NVTKTLETELERSDWSLLILHYLGL----------------DHIGHVEG--------NASPRVPL 225
            .:              |.||.:|.|                |..||..|        ..||..|.
Human   285 RI--------------LTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEESSYGSPFTPA 335

  Fly   226 K--------------------------------------------LKEMDEVVKKILD------- 239
            |                                            |:|:|::|.:::|
Human   336 KRPKRKVAPKRRQERPVAPPKKRRRKIHRMDHYAAETRQDKMTNPLREIDKIVGQLMDGLKQLKL 400

  Fly   240 HKSFPNVLLMLTGDHGMADG--------GGHGGNTPAETLVPLYL------YYNNCSKTPSASKR 290
            |:.   |.::..|||||.|.        ..:..|....||||..|      :.||....|.|.
Human   401 HRC---VNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAI-- 460

  Fly   291 YNQIDLAPTLSVLLSVEIPTLSIGCLIPEMLQSLSLEHQLYAYFYNAH-----HLLNKARVKFGH 350
                               ..::.|..|:         |.:..:...|     |..|..|::..|
Human   461 -------------------IANLTCKKPD---------QHFKPYLKQHLPKRLHYANNRRIEDIH 497

  Fly   351 EIVHRSDYYTWY 362
            .:|.|    .|:
Human   498 LLVER----RWH 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	64/350 (18%)
ENPP2	XP_006716647.1	SO	55..98	CDD:197571
		SO	99..142	CDD:197571
		Enpp	164..570	CDD:293742	74/402 (18%)
		Phosphodiest	166..530	CDD:279931	72/396 (18%)
		NUC	692..922	CDD:214683
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900