DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-G and Pigg

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001297618.1	Gene:	Pigg / 433931	MGIID:	3576484	Length:	983	Species:	Mus musculus

Alignment Length:	1060	Identity:	291/1060 - (27%)
Similarity:	455/1060 - (42%)	Gaps:	265/1060 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GAVLFLIGFFPA---SYSVAEKESTVPEGRPTALLGMELTP-PPPAYDSFVLLLVDALRDDFPDA 81
            |..:|:.|||||   |.:..|.::..|...|.|.:....|. |||.:...|::|:|||||||...
Mouse    19 GVAIFIRGFFPAPVRSSARPEHDAETPAPEPVAGVRSNWTKLPPPLFSKVVIVLIDALRDDFVFG 83

  Fly    82 TS----MPVAYSRACEKLKLHVDI-----PTVTMPRLKSITTGTLSNFIDIALNVGHTEQMQDSF 137
            :.    ||.. :...||...|..:     |||||||:|::.||:|..|:|:..|:.....::|:.
Mouse    84 SKGVKYMPYT-TYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPVLLEDNV 147

  Fly   138 LHRLKQQNRVVSFAGDHTWVKLFPSEFTRQVENHDSFYVNDFYEGDRNVTKTLETELERSDWSLL 202
            |.:.|...:.:.|.||.|||||||..|. :.:...||:|:|:.|.|:|||:.|:..|:|.||.:|
Mouse   148 LRQAKAAGKRIIFYGDETWVKLFPKHFV-EYDGTTSFFVSDYIEVDKNVTRHLDKVLKRGDWDVL 211

  Fly   203 ILHYLGLDHIGHVEGNASPRVPLKLKEMDEVVKKI------LDHKSFPNVLLMLTGDHGMADGGG 261
            ||||||||||||:.|..||.:..||.|||.|:.||      .|.::....||:|.|||||::.|.
Mouse   212 ILHYLGLDHIGHISGPNSPLIGHKLSEMDSVLMKIHTSLLSKDRETLLPSLLVLCGDHGMSETGS 276

  Fly   262 HGGNTPAETLVPLYLYYNNCSKTPS---ASKRYNQIDLAPTLSVLLSVEIPTLSIGCLIPEMLQS 323
            ||.::..|...||.|..:...:.|.   ..|...|.|||.||::.|.:.||..|:|.|:..:::.
Mouse   277 HGASSTEEVSTPLLLISSAFERKPGDIRHPKHVQQTDLAATLAIGLGLPIPKDSVGSLLFPVIEG 341

  Fly   324 LSLEHQLYAYFYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATLLHKKLLR---PLREGDGG--- 382
            ..:..||.....|                             ||...|||:   |..|.|.|
Mouse   342 KPMREQLRFLHLN-----------------------------TLQLSKLLQENVPSYEKDPGFEQ 377

  Fly   383 --GASQVYYQNAKL-------------------NYMRVAREISDLLSESLVKFDYGFIAVG---- 422
              .|.:::....||                   :|:...:.:|..||..:.::|...:|||
Mouse   378 FKMAEKLHGNWVKLHLEENHSDILLGLGTKVLRHYLGALKTLSLSLSTQVAQYDMYSMAVGTLIV 442

  Fly   423 ---LALTTSTSLHIVISVLYLDLTEQLQLDGLKVGQLWLSVIAAVVLNYTSHALDIIMTSSTLY- 483
               |||...::.|::.....||:.....:..|....::| |::|:      |.|....:.|:.|
Mouse   443 LEVLALFLLSTPHVLCRKAELDVPLLSPVFSLLFYLVFL-VLSAI------HVLVCTSSESSCYL 500

  Fly   484 ---------SILLLVP------ISIAVYLTIDVAQALLKIALPPLYTRRLKISIPLPLPLLACYA 533
                     :::|||.      :|..:.:.||  ..|||.......:...::::.|.|..:.
Mouse   501 CSLSWLAVGAVMLLVSALFCAILSALIRMVID--STLLKKNAADASSGWSEVNLLLLLGTVG--- 560

  Fly   534 IRTLTLGSSSFIEFEYNTWYYLGNTLILLTAFRTLRWRI-------------------------- 572
             ..|:||:|||:|.|:.|||:|.|||.|..:..|.|...
Mouse   561 -HVLSLGASSFVEEEHQTWYFLINTLCLALSQETCRSYFLGDECEPQRHSHVEQQCVNLLACPLQ 624

  Fly   573 --TKTNVELNGR-----HLYTIASTCLW--QMRKVLVVLMLLTLMRYI----------------- 611
              |..|...:|.     .|.....:|.|  .:....:||:...|:|.:
Mouse   625 DSTSYNTPESGTAGKRVSLLEAQGSCKWWTVLASPWLVLLCCRLLRSLNQTGVQGAHRPDFSHWL 689

  Fly   612 ----HRLQ----AIRSTVVIFSMLLLWARLHRHSQLPQSLASGAALFMVYCFRGLNGQVLF-FDV 667
                |::|    |..|.||||.:      :.|...|...:|....|..|:|:|...|.|.| :..
Mouse   690 TSSDHKVQLSGLAALSLVVIFML------VQRRCSLVSKVALALGLLGVFCYRAAIGIVQFPWQS 748

  Fly   668 PSHMAAKLMVPTLVIFWCCLALVLMLGYRAALPQAHSFGKVPPTGALLQLLQTNLTSS------- 725
            .:...:|.::....::...|. :|..|.:..|.              .|::.|:..:.
Mouse   749 DNKGISKGIIEARFVYVFVLG-ILFTGTKDLLK--------------AQVIATDFKTKTVGLWEM 798

  Fly   726 ----LLLAALLQRVHNILLLPVLLVALQQTYKLCDVYGTSARKFSVRLVHVYK---------IIM 777
                :||||||.|.||   ||||..:|        :..|...||      ::|         .:|
Mouse   799 HSGLVLLAALLLRPHN---LPVLAFSL--------LIQTVMTKF------IWKPLRHDAAEITVM 846

  Fly   778 TIFLARMFFFYQGNSNSLSTIDLTPGYIGQTNYNPSIVAIFVTL-NTYSADIHAFLYLVVHTLRS 841
            ..:..:.||::|||||:::|||::.|::|...| ..:.|.|:|: .||...:
Mouse   847 HYWFGQAFFYFQGNSNNIATIDISAGFVGLDTY-MEVPATFLTVFGTYVGPV------------- 897

  Fly   842 DLRSVGIMQLHPPYSIAADSLIAPL------YAALIMLPAAFYLCLLVGFRYHLFIYSVFSPKVL 900
                  :...|..|.::::...:.|      ||.:..:|.|.|:.|:...||||||:||||||:|
Mouse   898 ------LWASHLVYFLSSEGNNSALSRSCFCYALICSVPVATYIVLVTSLRYHLFIWSVFSPKLL 956

  Fly   901 YDCYTVLV---FYLVFLVTS 917
            |:...:|:   ...||..|:
Mouse   957 YEGMHLLITAAICAVFTATN 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	111/274 (41%)
Pigg	NP_001297618.1	GPI_EPT_2	62..335	CDD:293748	111/274 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850440
Domainoid	1	1.000	124	1.000	Domainoid score	I5535
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39421
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2690
Isobase	1	0.950	-	0	Normalized mean entropy	S3964
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313125at33208
OrthoFinder	1	1.000	-	-		FOG0005039
OrthoInspector	1	1.000	-	-		oto93942
orthoMCL	1	0.900	-	-		OOG6_104308
Panther	1	1.100	-	-	LDO	PTHR23072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R518
SonicParanoid	1	1.000	-	-		X3564
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740