DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-G and Pign

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_038812.2	Gene:	Pign / 27392	MGIID:	1351629	Length:	931	Species:	Mus musculus

Alignment Length:	995	Identity:	223/995 - (22%)
Similarity:	371/995 - (37%)	Gaps:	273/995 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVYTIGMLTAFLCGAVLFLIGFFPASYSVAEKESTVPEGRPTALLGM--ELTPPPPAYDSFVLLL 70
            |.:.:|:|..|:..|.:|.|.|            |.|     .:.||  :.||.||.....||.:
Mouse     3 LFFALGLLIHFVFFASIFDIYF------------TSP-----LVHGMTPQFTPLPPPAKRLVLFV 50

  Fly    71 VDALRDDF-----PDATSMP--------------VAYSRACEKLKLHVDIPTVTMPRLKSITTGT 116
            .|.||.|.     .|..|..              |:::|          :||.:.|...::..|.
Mouse    51 ADGLRADTLYELDEDGNSRAPFIRNVIMHEGSWGVSHTR----------VPTESRPGHVALIAGF 105

  Fly   117 LSNFIDIALNVGHTEQMQDSFLHRLK------QQNRVVSFA----GDHTWVKLFPSEFTRQVEN- 170
            ..:...:|..........||..:..|      ..:.:..||    |||    ::...:..|.|:
Mouse   106 YEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDH----VYTYSYDAQREDF 166

  Fly   171 --HDSF--------YVNDFYEGDRN----VTKTLETELERSDWSLLILHYLGLDHIGHVEGNASP 221
              ||:.        .|.||::..||    .||..|.::      :..||.||:|..||....:|.
Mouse   167 GAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKV------VFFLHLLGIDTNGHAHRPSSR 225

  Fly   222 RVPLKLKEMDEVVKKILD-HKSF----PNVLLMLTGDHGMADGGGHGGNTPAETLVPLYLYYNNC 281
            .....:|::|:.||:|:. .|.|    .....:.|.||||.|.|.||...|:|||.| ::.:...
Mouse   226 EYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTP-FVTWGAG 289

  Fly   282 SKTPS--ASKRY------------------NQIDLAPTLSVLLSVEIPTLSIGCLIPEMLQSLSL 326
            .|.|.  ::::|                  ||.|:||.::.|:.|..|..|:|.|....|.:..|
Mouse   290 IKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPVGYLNNTGL 354

  Fly   327 EHQLYAYFYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATL----LHKKLLRPLREGDGGGASQV 387
             .:..:.|.||..:|.:.:||.           |..:.|||    ...|||...::.|....::.
Mouse   355 -FKAESMFTNAVQILEQFKVKM-----------TQKKEATLPFLFTPFKLLSDSQQLDILRKARS 407

  Fly   388 YYQNAKLN-YMRVAREISDLLSESLV---KFDYGFIAVGLAL-----TTSTSLHIVISVLYLDLT 443
            |.:..|.: .:.:..|:.||....|.   .:|..|:.:.:|:     .:.|||.|:.|  :.::.
Mouse   408 YIKQEKFDEVVSLCEELIDLALRGLSYYHTYDRLFLGINVAVGFVGWMSYTSLLIIKS--HSNIP 470

  Fly   444 EQLQLDGLKVGQLWL-SVIAAVVLNYTSHALDIIMTSSTLYSILLL-VPISIAVYLTIDVAQALL 506
            :..:.:|.|...|.| |.||..||  .:..|.|.....|.|...|| |||..||....:|.|.|:
Mouse   471 KGTRKEGKKPHCLLLYSFIATGVL--VACFLMIQACPWTYYVYCLLPVPIWYAVLREHEVIQDLV 533

  Fly   507 KIALPPLYTRRLKISIPLPLPLLACYAIRTLTLGSSSFIEFEYNTWYYLGNTLILLTAFRTLRWR 571
            :                           ..||...|.|:  .|...:.||..:::|:.|  .|:.
Mouse   534 E---------------------------SLLTFPRSHFV--AYLLVFTLGIEVLVLSFF--YRYM 567

  Fly   572 ITKTNVELNGRHLYTIASTCLWQMRKVL--------VVLMLLTLMRYIHR---LQAIRST---VV 622
            :|...:...|....    |.||...|:.        ::|.:..||..:.|   |..:...   |:
Mouse   568 LTAGLIVFAGWPFL----TQLWTRAKITFLSWAFFSLLLAVFPLMPVVGRKPNLSLVMGAGFLVL 628

  Fly   623 IFSMLLLWARLHRHSQLP---------QSLASGAALFMVYCFRGLNGQVLFFDVPSHMAAK---L 675
            :.|:.::.....|:.:|.         |.|::..::::||.             ..|...|   |
Mouse   629 LLSLAVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVYS-------------THHSLLKKEGL 680

  Fly   676 MVPTLVIFWCCLA--LVLMLGYRAALPQAHSFGKVPPTGALLQLLQTNLTSSLLLAALLQRVHNI 738
            .:...::.|..||  ||..|....||.|           .|..:|.:.:::.|||:...:.:..:
Mouse   681 PLMNQIVSWATLASSLVAPLLSSTALSQ-----------RLASILLSLMSTYLLLSTGYEALFPL 734

  Fly   739 LLLPVLLVALQQTYKLCDVYGTSARK--FSVRLV--------------HVYKIIMTIFLARMFFF 787
            :|..::.|.:|...:.....|.|.::  .|::..              .:.:....:|.....||
Mouse   735 VLSCLMFVWIQVEQETLQQPGVSCKQKLTSIQFTCDTDIAQFRQLCPDDIRRAFFLVFFLLTAFF 799

  Fly   788 YQGNSNSLSTIDLTPGYIGQTNYNPSIV--------------------AIFVTLNTYSADIHAFL 832
            ..||..|:::.||...|...|.::|.::                    |:.:|....|..    |
Mouse   800 GTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKG----L 860

  Fly   833 YLVVHTLRSDLRSVGIMQLH 852
            :||| .:.||     ||.||
Mouse   861 FLVV-LIISD-----IMALH 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	79/325 (24%)
Pign	NP_038812.2	GPI_EPT_1	40..345	CDD:293744	79/325 (24%)
Pign	NP_038812.2	PigN	431..884	CDD:368221	108/517 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810