DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-G and PIGN

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_011524191.1	Gene:	PIGN / 23556	HGNCID:	8967	Length:	970	Species:	Homo sapiens

Alignment Length:	1076	Identity:	238/1076 - (22%)
Similarity:	386/1076 - (35%)	Gaps:	301/1076 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVYTIGMLTAFLCGAVLFLIGFFPASYSVAEKESTVPEGRPTALLGM--ELTPPPPAYDSFVLLL 70
            |.:|:|:|..|:..|.:|.|.|            |.|     .:.||  :.||.||.....||.:
Human     3 LFFTLGLLIHFVFFASIFDIYF------------TSP-----LVHGMTPQFTPLPPPARRLVLFV 50

  Fly    71 VDALRDDFPDATSMPVAY-------SRACEKLKL----------HVDIPTVTMPRLKSITTGTLS 118
            .|.||.|        ..|       |||.....:          |..:||.:.|...::..|...
Human    51 ADGLRAD--------ALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYE 107

  Fly   119 NFIDIALNVGHTEQMQDSFLHRLK------QQNRVVSFA----GDHTWVKLFPS---EFTRQ-VE 169
            :...:|..........||..:..|      ..:.:..||    |||.:...:.:   :|..| ..
Human   108 DVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDAT 172

  Fly   170 NHDSFY---VNDFYEGDRNVTKTLETELERSDWSLLILHYLGLDHIGHVEGNASPRVPLKLKEMD 231
            ..|::.   |.||:...|| .::|.::: ..:..:..||.||:|..||....:|......:|::|
Human   173 KLDTWVFDNVKDFFHHARN-NQSLFSKI-NEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVD 235

  Fly   232 EVVKKIL---------DHKSFPNVLLMLTGDHGMADGGGHGGNTPAETLVPLYLYYNNCSKTPSA 287
            :.||:|:         |.|:    ..:.|.||||.|.|.||...|:|||.||..:..........
Human   236 DGVKEIVSMFNHFYGNDGKT----TFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRV 296

  Fly   288 S-----------------KR--YNQIDLAPTLSVLLSVEIPTLSIGCLIPEMLQSLSLEHQLYAY 333
            |                 ||  .||.|:||.::.|:.|..|..|:|.|..:.|.:..| .:..:.
Human   297 SAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDL-FKAESM 360

  Fly   334 FYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATLLHKKLLRPLREGDGGGASQVYYQNAKLNYMR 398
            |.||..:|.:.:||.           |..:..||  ..|..|.:         :...:.:.|.:|
Human   361 FTNAVQILEQFKVKM-----------TQKKEVTL--PFLFTPFK---------LLSDSKQFNILR 403

  Fly   399 VAR---------EISDLLSESLVKFDYGFIAVGLALTTSTSLHIVISVLYLDLTEQLQLDGLKVG 454
            .||         |:..|..|          .:.|||...:..| .....:|.:...:...|
Human   404 KARSYIKHRKFDEVVSLCKE----------LIHLALKGLSYYH-TYDRFFLGVNVVIGFVG---- 453

  Fly   455 QLWLSVIAAVVLNYTSHALDIIMTSSTLYSILLLVPISIAVYLTIDVAQALLKIALPPLYTRRLK 519
              |:|..:.:::.  ||:..|...|..:.....|:|.|. |.:.|.||..||..|.|  :|..:.
Human   454 --WISYASLLIIK--SHSNLIKGVSKEVKKPSHLLPCSF-VAIGILVAFFLLIQACP--WTYYVY 511

  Fly   520 ISIPLPL--------PLLACYAIRTLTLGSSSFIEFEYNTWYYLGNTLILLTAFRTLRWRITKTN 576
            ..:|||:        .::....:..||...|.|:  .|...:.||..:::|:.|  .|:.:|
Human   512 GLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFV--GYLLAFTLGIEVLVLSFF--YRYMLT--- 569

  Fly   577 VELNGRHLYTIAS----TCLWQMRKVL--------VVLMLLTLMRYIHRLQAIRST------VVI 623
                 ..|...|:    |.||...|:.        ::|.:..||..:.|...|...      |::
Human   570 -----AGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLL 629

  Fly   624 FSMLLLWARLHRHS---------QLPQSLASGAALFMVYCFRGLNGQVLFFDVPSHMAAKLMVPT 679
            .|:.::.:.:.|..         .|.|.|::..::::||            ...|.:..|..:|.
Human   630 LSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVY------------STQSSLLRKQGLPL 682

  Fly   680 L--VIFWCCLA---LVLMLGYRAALPQAHSFGKVPPTGALLQLLQTNLTSSLLLAALLQRVHNIL 739
            :  :|.|..||   :|.:|.......:..|.        ||.|:.|.|..|....||...|.:.|
Human   683 MNQIISWATLASSLVVPLLSSPVLFQRLFSI--------LLSLMSTYLLLSTGYEALFPLVLSCL 739

  Fly   740 LLPVLLV---ALQQT-----YKLCDV---YGTSARKF-SVRLVHVYKIIMTIFLARMFFFYQGNS 792
            :...:.:   .|||:     .||..:   |.|...:| .:.|..:.:....:|.....||..||.
Human   740 MFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNI 804

  Fly   793 NSLSTIDLTPGYIGQTNYNPSIVAIF------------------VTLNTYSADIHAFLYLVVHTL 839
            .|:::.||...|...|.::|.::...                  |.|.|..:....||.::|
Human   805 ASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLV--- 866

  Fly   840 RSDLRSVGIMQLHPPYSIAADSLIAPLYAALIMLPAAFYLCLLVGFRY------HLFIYSVFSPK 898
            .||     ||.||                 ...|...:...|.:|.|.      .||:|...||.
Human   867 ISD-----IMALH-----------------FFFLVKDYGSWLDIGTRQLLACTAWLFMYISASPN 909

  Fly   899 VLY----------------DC---YTVLVFYLVFLV 915
            .|:                .|   |.:::...:|||
Human   910 RLWMLSDPGLDLNLLHAIRACISHYVIVMSMTIFLV 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	78/318 (25%)
PIGN	XP_011524191.1	Npp1	7..>280	CDD:224441	74/303 (24%)
		GPI_EPT_1	40..345	CDD:293744	78/318 (25%)
		PigN	431..884	CDD:282796	107/521 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910