DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-G and Enpp1

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001295256.1	Gene:	Enpp1 / 18605	MGIID:	97370	Length:	906	Species:	Mus musculus

Alignment Length:	611	Identity:	130/611 - (21%)
Similarity:	220/611 - (36%)	Gaps:	137/611 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 TPPPPA-YDS--FVLLLVDALRDDFPDATS--MPVAYSRACEKLK--------LHVDIPTVTMPR 108
            ||..|| ::|  .:|..:|..|.::.....  :||     ..|||        :....||.|.|.
Mouse   182 TPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPV-----ISKLKNCGTYTKNMRPMYPTKTFPN 241

  Fly   109 LKSITTGTLSNFIDIALNVGHTEQMQDSFLHRLKQQNRVVSFAGDHTWVKLFPSEFTRQVENHDS 173
            ..||.||.......|..|..:..:|..||..:.|::...:.:.|...||    :...::|::...
Mouse   242 HYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWV----TANHQEVKSGTY 302

  Fly   174 FYVNDFYEGD---RNVTKTLETELERSDWSLLILHYLGL----------------DHIGHVEGNA 219
            |:.....|.|   .::.|.....:...:..|.:|.:|.|                |..||..|..
Mouse   303 FWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPV 367

  Fly   220 SPRVPLKLKEMDEVVKKILD---HKSFPNVL-LMLTGDHGMADGG-----------GHGGNT--- 266
            |..|...|:::|.:|..::|   .......| |:|..||||..|.           |...|.
Mouse   368 SSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNNVKVV 432

  Fly   267 --PAETLVP-----LYLYYN--------NCSKTPSASKRYNQIDLAPTLSVLLSVEIPTLSIGCL 316
              ||..|.|     .|..:|        :|.:.....:.|.:..|...|....|..|..|:. .|
Mouse   433 YGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHFRPYLKPFLPKRLHFAKSDRIEPLTF-YL 496

  Fly   317 IPEMLQSLSLEHQLY--AYFYNAHHLLNKAR---VKFGHEIVHRSDYYTWYQNATL--LHKKLLR 374
            .|:...:|:...:.|  :.|:.:.:|.:..:   :.:|....|.::..: ::|..:  |...||.
Mouse   497 DPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDS-FENIEVYNLMCDLLG 560

  Fly   375 PLREGDGGGASQVYYQNAKLNYMRVAREISDLLSESLVKFDY----GFIAVGLALTTSTSLHIVI 435
            .:...:.|       .:..||:         ||.:.:....:    ||::.....:||..|....
Mouse   561 LIPAPNNG-------SHGSLNH---------LLKKPIYNPSHPKEEGFLSQCPIKSTSNDLGCTC 609

  Fly   436 S---VLYLDLTEQLQLDGLKVGQLWLSVI----AAVVLNYTSHALDIIMTSSTL--YSILLLVPI 491
            .   |...|..:||.|....|..::...:    ..::|.  .|.:.::.....|  ||:.||:|:
Mouse   610 DPWIVPIKDFEKQLNLTTEDVDDIYHMTVPYGRPRILLK--QHRVCLLQQQQFLTGYSLDLLMPL 672

  Fly   492 SIAVYLTI--------DVAQAL---LKIALPPL-----YTRRLKISIP-LPLPLL-----ACYAI 534
             .|.|..:        |.:..|   |:|.|.|:     |....|:|.. |..|.|     ..|:.
Mouse   673 -WASYTFLSNDQFSRDDFSNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTPPRLNRVSNHIYSE 736

  Fly   535 RTLTLGSSSFIEFEYNTWYYLGNTLI 560
            ..||.......:.....|:||.:||:
Mouse   737 ALLTSNIVPMYQSFQVIWHYLHDTLL 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	70/321 (22%)
Enpp1	NP_001295256.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Di-leucine motif. /evidence=ECO:0000269\|PubMed:11598187, ECO:0000269\|PubMed:15075217	27..34
		SO	86..126	CDD:197571
		SO	127..170	CDD:197571
		Phosphodiesterase. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	173..573		85/408 (21%)
		Enpp	192..560	CDD:293742	78/378 (21%)
		Phosphodiest	194..520	CDD:279931	72/335 (21%)
		Linker. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	579..628		10/48 (21%)
		Nuclease. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	635..906		30/131 (23%)
		NUC	657..888	CDD:214683	28/107 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900