DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-G and pigo-1

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_491750.3	Gene:	pigo-1 / 172285	WormBaseID:	WBGene00016159	Length:	883	Species:	Caenorhabditis elegans

Alignment Length:	1010	Identity:	225/1010 - (22%)
Similarity:	416/1010 - (41%)	Gaps:	245/1010 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVYTIGMLTAFLCGAVLFLIGFFPASYSVAEKES-TVPEGRPTALLGMELTPPPPAYDSFVLLLV 71
            |:.:|.:|.|..    :|..||......:..|.| :....:|.....|:     ..|...:|:||
Worm     8 LLVSINILLALF----IFQNGFLLKRQEILSKSSCSDAHAQPGQTCWMK-----QQYQRVILILV 63

  Fly    72 DALRDDFPDATSMPVA----------YSRA----CEKL---------KLHVDIPTVTMPRLKSIT 113
            ||||.||    .:|:.          |.|.    .|||         .|..|.||.|:.|||::|
Worm    64 DALRYDF----LIPIDENTKKSKEEWYYRGQMKNIEKLVKSGNVSIGTLLADPPTTTLQRLKALT 124

  Fly   114 TGTLSNFIDIALNVGHTEQM-QDSFLHRLKQQNRVVSFAGDHTWVKLFPSEFTRQVENHDSFYVN 177
            ||||..|||...|......: :|||:::..|..:.|:..||.||:.|||::|::... :|||.:|
Worm   125 TGTLPTFIDAGDNFSPDAVISEDSFVYQAAQLGKNVTLLGDDTWLSLFPNQFSKTAA-YDSFDIN 188

  Fly   178 DFYEGDRNVTKTLETELERSDWSLLILHYLGLDHIGHVEGNASPRVPLKLKEMDEVVKKILDHKS 242
            |....|..:...|:.|:..|:.|::|.|:||:||.||..|.:.|.:...|::||.::.:.::
Worm   189 DLNTVDDKIAPILQDEMLNSNSSIIIAHFLGVDHCGHKFGPSHPVMADTLRKMDRIIGQTIE--- 250

  Fly   243 FPNVLLMLTGDHGMADGGGHGGNTPAETLVPLYLYYNNCSKTPSASKRY---------NQIDLAP 298
                 .|.:.||||...|.|||.:..|....:.::          ||::         :|||:.|
Worm   251 -----TMKSDDHGMTSTGDHGGESENEIRAGILVH----------SKKHQIILPERPIHQIDIVP 300

  Fly   299 TLSVLLSVEIPTLSIGCLIPEMLQSLSLEHQLYAYFYNAHHLLNKARVKFGHEIVHR-SDYYTWY 362
            |:|:|:.:.||..::|.:|.::     ....|:           :..|...:|.|.| ::.|...
Worm   301 TISLLMGLPIPFSNLGTVITQL-----FTRDLW-----------EIAVGMNYEQVKRFAETYAAQ 349

  Fly   363 QNATLLHKKLLRPLREGDGGGASQVYYQNAKLNYMRVAREISDLLSESLVKFDYGFIAVGLALTT 427
            :|...||...:|.              .|.....:.....|..||..|..:||..:|..|:
Worm   350 KNFGELHSHTIRD--------------SNTMEEQLDTMSRIQTLLRVSWTQFDDAYINAGI---- 396

  Fly   428 STSLHIVISVLYLDLTEQLQLDGLKVGQLWLSVIAAVVLNYTSHALDIIMTSSTLYSILLLVPIS 492
               ..:|.::::|...|.:.|:       |:.......|...:...|...:..:..::||:.
Worm   397 ---FSLVEAIMFLITNEVMSLE-------WIIYRTGCGLLQAALLTDKTDSDGSARTLLLMT--- 448

  Fly   493 IAVYLTIDVAQALLKIALPPLYTRRLKISIPLPL------PLLACYAIRTLTLGSSSFIEFEYNT 551
                |.:....:::.:....|   :::|||...|      |:|.  .|.:::|.|:|::.:|...
Worm   449 ----LAVSCLSSIISMCHKAL---QIRISIKSMLSAKVIGPILV--IIHSISLFSNSYVVYEAQV 504

  Fly   552 WYYLGNTLILLTAFRTLRWRITKTNVELNGRHLYTIASTCLWQMRKVLVVLMLLTLMRYIHRLQA 616
            ..|...:|:.|.....||                   ||.| :.||   ...|..|.:::::.|
Worm   505 VRYFLQSLVTLVFLEKLR-------------------STAL-RPRK---PFKLNFLWKFVNQDQ- 545

  Fly   617 IRSTVVIFSMLLLWAR--------------------------LHRHSQLPQ------SLA-SGAA 648
               .::||:::::..|                          |.|.:|:.:      ||| :..:
Worm   546 ---NLIIFTLIMVGLRSEPIFHRCREEEVGCDTYYPSRQAGSLTRDAQVVRLLFALGSLAVANLS 607

  Fly   649 LFMVYCFRGLNGQVLFFDVPSHMAAKLMVPTLVIFWCCLALVLMLGYRAALP--------QAHSF 705
            :|..|..|....|:......|....:::..|   .|..:|::::....|:|.        .|||.
Worm   608 VFKYYGLRDTKSQIESNSKRSSETIRILSAT---SWLHIAIIVLHSVFASLTHDVSRANLSAHSL 669

  Fly   706 GKVPPTGALLQLLQTNLTSSLLLAALLQRVHNIL---LLPVLLVALQQTYKLCDVYGTSARKFSV 767
            ..:....|:|...:.|  |::....||..|:.:.   |:|.:::.:..:..:.:..   :|:|
Worm   670 SVISLICAVLAWREGN--SAICAHFLLMPVYILFGDGLIPAIIIFIAVSVLIAEFV---SREF-- 727

  Fly   768 RLVHVYKIIMTI-FLARMFFFYQGNSNSLSTIDLTPGYIGQTNYNPSIVAIFVTLNTYSADIHAF 831
                   |..|| .|..:.|::.|:|..:|:|.....::|    .|...|:.|.         ..
Worm   728 -------IASTIALLIPLGFYHLGHSPVISSIPWNAAFVG----IPGGTALRVL---------PA 772

  Fly   832 LYLVVHTLRSDLRSVGIMQLHPPYSIAADSLIAP-----LYAALIMLPAAFYLCLLVG--FRYHL 889
            |:::.|...|.:.|:.::...   |.::..:.||     |...|:::.....|..||.  .|.||
Worm   773 LFVLFHLNFSAISSIFVISSE---SESSQKMSAPNTAWTLTETLVLMTIRATLTCLVSSIHRRHL 834

  Fly   890 FIYSVFSPKVLYDCYTVLVFYLVFLVTSLYFKLFK 924
            .::.:|:||.:::|    :..:||:.::.:|.:::
Worm   835 MVWKIFAPKFIFEC----ILTIVFIFSANFFLIYR 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	91/289 (31%)
pigo-1	NP_491750.3	GPI_EPT_3	52..319	CDD:293747	91/294 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313125at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820