DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-G and Pigg

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_003751363.1	Gene:	Pigg / 100910143	RGDID:	1560335	Length:	986	Species:	Rattus norvegicus

Alignment Length:	1048	Identity:	285/1048 - (27%)
Similarity:	449/1048 - (42%)	Gaps:	238/1048 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GAVLFLIGFFPA---SYSVAEKESTVPEGRPTALLGMELTP-PPPAYDSFVLLLVDALRDDFPDA 81
            |..:|:.|||||   |.:..|..:..|...|.|.:....|. |||.:...|::|:|||||||...
  Rat    19 GVAIFIRGFFPAPVRSSARPEHGAETPAPEPVAGVSSNWTKLPPPLFSKVVIMLIDALRDDFVFG 83

  Fly    82 TS----MPVAYSRACEKLKLHVDI-----PTVTMPRLKSITTGTLSNFIDIALNVGHTEQMQDSF 137
            :.    ||.. :...||...|..:     |||||||:|::.||:|..|:|:..|:.....::|:.
  Rat    84 SKGVKYMPYT-TYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPVLLEDNV 147

  Fly   138 LHRLKQQNRVVSFAGDHTWVKLFPSEFTRQVENHDSFYVNDFYEGDRNVTKTLETELERSDWSLL 202
            :.:.|...:.:.|.||.|||||||..|. :.:...||:|:|:.|.|.|||:.|:..|.|.||.:|
  Rat   148 IRQAKAAGKRIIFYGDETWVKLFPKHFV-EYDGTTSFFVSDYIEVDNNVTRHLDKVLRRGDWDVL 211

  Fly   203 ILHYLGLDHIGHVEGNASPRVPLKLKEMDEVVKKI------LDHKSFPNVLLMLTGDHGMADGGG 261
            ||||||||||||:.|..||.:..||.|||.|:.||      .|.::....||:|.|||||::.|.
  Rat   212 ILHYLGLDHIGHISGPNSPLIGHKLSEMDSVLMKIHTSLLSKDRETLLPSLLVLCGDHGMSETGS 276

  Fly   262 HGGNTPAETLVPLYLYYNNCSKTPS---ASKRYNQIDLAPTLSVLLSVEIPTLSIGCLIPEMLQS 323
            ||.::..|...||.|..:...:.|.   ..|...|.|||.||::.|.:.||..::|.|:..:::.
  Rat   277 HGASSTEEVSTPLLLISSAFERKPGDVRHPKHVQQTDLAATLAIGLGLPIPKDNVGSLLFPVIEG 341

  Fly   324 LSLEHQLYAYFYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATLLHKKLLR---PLREGDGG--- 382
            ..:..||.....|                             ||...|||:   |..|.|.|
  Rat   342 KQMREQLRFLHLN-----------------------------TLQLSKLLQENIPAYEKDPGFEQ 377

  Fly   383 --GASQVYYQNAKLN-------------------YMRVAREISDLLSESLVKFDYGFIAVG---- 422
              .|.:::....||:                   |:...:.:|..||..:..:|...:|||
  Rat   378 FKMAERLHGNWVKLHLEENHSDILLGLGTKVLRQYLGALKTLSQSLSTQVAHYDIYSMAVGTLMV 442

  Fly   423 ---LALTTSTSLHIVISVLYLDLTEQLQLDGLKVGQLWLSVIAAVVLNYTSHALDIIMTSSTLY- 483
               |.|...::.|::.....||:.....:..|....::| |::|:      |.|....:.|:.|
  Rat   443 LEVLTLFLLSTPHVLCRKAELDVPLLSPVFSLLFYLIFL-VLSAI------HVLVCTSSESSCYL 500

  Fly   484 ---------SILLLVPISIAVYLTIDVAQALLKIALPPLYTRR---------LKISIPLPLPLLA 530
                     ::::||.......|:     ||:::.......|:         .::::.|.|..:.
  Rat   501 CNLPWLAAGAVMVLVSALFCAILS-----ALIRMVTDGTLLRKNATVASSGWSEVNLLLLLGTVG 560

  Fly   531 CYAIRTLTLGSSSFIEFEYNTWYYLGNTLILLTAFRTLRWRITKTNVELNGRHLYTIASTCL--- 592
                ..|:||:|||:|.|:.|||:|.|||.|..:..|.|......:.|  .:|.:.:...|:
  Rat   561 ----HVLSLGASSFVEEEHQTWYFLINTLCLALSQETCRSYFLGDDCE--PQHHFQVEQKCVNVL 619

  Fly   593 -----------------------------------WQ-MRKVLVVLMLLTLMRYI---------- 611
                                               |. :....:||:...|:|.:
  Rat   620 ACTLQDSTSCSTPESESDTAGKRASLLEAHRSCKWWTVLASPWLVLICCRLLRSLNQTGVQGAHR 684

  Fly   612 -----------HRLQAIRSTVVIFSMLLLWARLHRHSQLPQSLASGAALFMVYCFRGLNGQVLFF 665
                       |::..  |.:...|:::::..:.:...|...:|....|..|:|:|...|.|||.
  Rat   685 PDFSHWLTSSDHKVHL--SGLAALSLVVIFILVQKGCSLVSKVALALGLLGVFCYRAAIGIVLFP 747

  Fly   666 DVPSHMAAKLMVPTLVIFWCCLALVLMLGYRAALPQ---AHSFGKVPPTGALLQLLQTNLTSSLL 727
            ..|.:......:......:..:..:|..|.:..|..   |..| |....|  |..:.:.|   :|
  Rat   748 WQPDNKGISKGITEARFVYVFVLGILFTGTKDLLKAQVIAADF-KTKIVG--LWEIHSGL---VL 806

  Fly   728 LAALLQRVHNILLLPVLLVALQQTYKLCDVYGTSARKFSVRLVHVYK---------IIMTIFLAR 783
            |||||.|.||   ||||..:|        :..|...||      ::|         .:|..:..:
  Rat   807 LAALLLRPHN---LPVLAFSL--------LIQTVMTKF------IWKPLRHDAAEVTVMHYWFGQ 854

  Fly   784 MFFFYQGNSNSLSTIDLTPGYIGQTNYNPSIVAIFVTL-NTYSADIHAFLYLVVHTLRSDLRSVG 847
            .||::|||||:::|||::.|.:|...| ..:.|.|:|: .||...:....:||..     |.|.|
  Rat   855 AFFYFQGNSNNIATIDISAGCVGLETY-MEVPATFLTVFGTYVGPVLWASHLVYF-----LSSEG 913

  Fly   848 IMQLHPPYSIAADSLIAPLYAALIMLPAAFYLCLLVGFRYHLFIYSVFSPKVLYDCYTVLV---F 909
                   .:.:|.|.....||.:..:|.|.|:.|:...||||||:||||||:||:...:|:   .
  Rat   914 -------NNGSALSRACFCYALICSVPVATYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAI 971

  Fly   910 YLVFLVTS 917
            ..||..|:
  Rat   972 CAVFTATN 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	109/274 (40%)
Pigg	XP_003751363.1	GPI_EPT_2	62..335	CDD:293748	109/274 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354137
Domainoid	1	1.000	105	1.000	Domainoid score	I6522
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39421
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2853
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313125at33208
OrthoFinder	1	1.000	-	-		FOG0005039
OrthoInspector	1	1.000	-	-		oto97474
orthoMCL	1	0.900	-	-		OOG6_104308
Panther	1	1.100	-	-	LDO	PTHR23072
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3564
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800