DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-G and pigg

DIOPT Version :9

Sequence 1:	NP_610292.2	Gene:	PIG-G / 35685	FlyBaseID:	FBgn0033187	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_002941164.2	Gene:	pigg / 100487165	XenbaseID:	XB-GENE-6046154	Length:	984	Species:	Xenopus tropicalis

Alignment Length:	1006	Identity:	294/1006 - (29%)
Similarity:	466/1006 - (46%)	Gaps:	179/1006 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GAVLFLIGFFPASYSVAEKES----TVPEGRPTALLGMELTPPPPAYDSFVLLLVDALRDDF--- 78
            ||:||:.||||.......::|    |.||.....||......|.|.:...|:||:||||.||
Frog    19 GAMLFIRGFFPLPVRSQSRKSTSAETPPEPATAGLLSNWTKLPSPLFKKVVVLLIDALRQDFVYG 83

  Fly    79 PDATSMPVAYSRACEKLKLHVDI-----PTVTMPRLKSITTGTLSNFIDIALNVGHTEQMQDSFL 138
            |.........::..||...|..|     |||||||:|::.||::..|||:.:|:...|.:.|:.:
Frog    84 PKGKKHMPYLTQLVEKGTTHSFIAKAAAPTVTMPRIKALMTGSIPGFIDVVMNLNSHELLDDNVI 148

  Fly   139 HRLKQQNRVVSFAGDHTWVKLFPSEFTRQVENHDSFYVNDFYEGDRNVTKTLETELERSDWSLLI 203
            .:.||..:.:.|.||.||:||||..|. :.:...||:|:|:.|.|.|||:.|:..|:|:||.:||
Frog   149 WQGKQAGKRIVFYGDDTWIKLFPKHFA-EYDGTTSFFVSDYTEVDNNVTRHLDDILKRNDWDMLI 212

  Fly   204 LHYLGLDHIGHVEGNASPRVPLKLKEMDEVVKKIL-------DHKSFPNVLLMLTGDHGMADGGG 261
            |||||||||||:.|..|..|..||.|||.|:|||.       :..|.|: |::|.|||||::.|.
Frog   213 LHYLGLDHIGHLTGPHSHLVGPKLLEMDTVLKKISVALMSQEEDISVPS-LIVLCGDHGMSETGS 276

  Fly   262 HGGNTPAETLVPLYLYYN------NCSKTPSASKRYNQIDLAPTLSVLLSVEIPTLSIGCLIPEM 320
            |||::..|...||.|..:      ..||.|..   ..|.|:||||::.|.:.||..|:|.|:|:.
Frog   277 HGGSSEEEVQTPLVLISSAFEEKGGISKLPEI---IQQTDIAPTLAISLGLPIPQNSLGILVPQT 338

  Fly   321 LQSLSLEHQLYAYFYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATLLHKKLLRPLREGDGGGAS 385
            ::..|:..||.....|.|.|....|...  |...:......::.|...|...::...||:.....
Frog   339 VEHKSMREQLRFLHLNGHQLCMLLRQNL--EAYEKDAGVEQFKKAEKSHGNWIKLYLEGNASETL 401

  Fly   386 QVYYQNAKLNYMRVAREISDLLSESLVKFDYGFIAVGLALTTSTSLHIVISVLYLDLTEQLQLDG 450
            ....:.....|:...:.:|..|.:.:.::|...:::|..::......:::|:... |:.:.:.|.
Frog   402 TNLGKKVLKQYLEALKNLSSSLGKQIAEYDIYSMSIGAVISLEILFLLLLSIPNA-LSSRAEFDI 465

  Fly   451 LKVGQLW--LSVIAAVVLNYTSHALDIIMTSST-----LYSILLLVPISIAVY---LTIDVAQAL 505
            .....|:  |..:..:||:    |:.:|:.:|:     ..||..::.:.|.::   |:..|...|
Frog   466 PLSSPLFSLLFYMMCLVLS----AIHVIVCTSSEKVCFFCSISWVLALGIMMFISALSCIVLSTL 526

  Fly   506 LKIALPPLYTRRLKISI-----PLPLPLLACYAIRTLTLGSSSFIEFEYNTWYYLGNTLILLTAF 565
            .|:.....|..:.:.||     .|.|.||.......:::|:|||||.|:.|||:|.|||.|..|.
Frog   527 SKMLAKSQYPNKKQDSIFSGWSELDLLLLIGTLGHVISMGASSFIEEEHQTWYFLTNTLCLALAQ 591

  Fly   566 RTLR--WRITKTNV------------------------------------ELNGRHLYTIASTCL 592
            ...|  :.:.|:|.                                    :...:|...||.:..
Frog   592 EMCRKYFLVKKSNFLDSAEGEDSKNESLYMDKIYDTHKKELKEQTLPLLSQFAKQHEKWIALSSP 656

  Fly   593 WQMRKVLVVLMLL-----TLMRYIHR---------------LQAIRSTVVIFSMLLLWARLHRHS 637
            |   .:|::..||     |.:::|||               |..:.:..::...:|:..|....|
Frog   657 W---AILIICRLLRTLNQTGIQWIHRPDFGHWLTSSEHKPELSFLVAVCLVMIFILIQGRCSFVS 718

  Fly   638 QLPQSLASGAALFMVYCFRGLNGQVLF-FDVPSHMAAKLMVPTLVIFWCCLALVLMLGYRAAL-- 699
            ::  :||.|  |..:||:|...|.||: :...|:..:|.:.....::...|. :|..|.:..|
Frog   719 KV--ALAFG--LLGIYCYRAAIGHVLYPWQNNSNGLSKGITEARFVYIFVLG-ILFTGTKDLLKS 778

  Fly   700 ------PQAHSFGKVPPTGALLQLLQTNLTSSLLLAALLQRVHNILLLPVLLVALQQTYKLCDVY 758
                  ||..|.|           |....:..:||||||.|.||:::| |..:.:|.|
Frog   779 QVIYTDPQTKSLG-----------LWEVYSGFILLAALLYRPHNLVVL-VFCLLMQTT------- 824

  Fly   759 GTSARKFSVRLVHVYK------IIMTIFLARMFFFYQGNSNSLSTIDLTPGYIGQTNYNPSIVAI 817
                  .|:.:.::.|      .||..:..:.|||:|||||::||:|::.|::|..|| ..:.||
Frog   825 ------LSMFIWNLLKHDAAQITIMHYWFGQAFFFFQGNSNTISTVDISAGFVGMENY-VELPAI 882

  Fly   818 FVTL-NTYSAD----IHAFLYLVVHTLRSDLRSVGIMQLHPPYSIAADSLIAPLYAALIMLPAAF 877
            |:|: .|||..    ||...|     |.|:...|.....|..|          .|||:..:|...
Frog   883 FLTMFITYSGPLLWAIHLLWY-----LSSETHRVSTTVAHGCY----------CYAAIRSIPVTV 932

  Fly   878 YLCLLVGFRYHLFIYSVFSPKVLYDCYTVLV 908
            |:.::..|||||||:||||||:||:...:|:
Frog   933 YILVVTAFRYHLFIWSVFSPKLLYEAIHLLI 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	113/277 (41%)
pigg	XP_002941164.2	GPI_EPT_2	62..335	CDD:293748	113/277 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3878
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39421
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2363
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313125at33208
OrthoFinder	1	1.000	-	-		FOG0005039
OrthoInspector	1	1.000	-	-		oto104165
Panther	1	1.100	-	-	LDO	PTHR23072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R518
SonicParanoid	1	1.000	-	-		X3564
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100