DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1602 and ZNF665

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	391	Identity:	109/391 - (27%)
Similarity:	163/391 - (41%)	Gaps:	71/391 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 KEPKKCKEALKRMAIDLEATV--SVFLNEMALKL-AIKKV--HMQFNTVHKRVVSGKQKPQSL-- 233
            ::|.||.|..|..::....|.  ::...|...|. ...||  |..:...|:|:.:| :||...
Human   343 EKPYKCNECGKAFSVRSSLTTHQTIHTGEKPYKCNECGKVFRHNSYLAKHRRIHTG-EKPYKCNE 406

  Fly   234 ---AFSIYKLCCFLNASNDEEGATNNEKIKLDFSKKNKLTTDLIEMYANFPQLYDSNHKEFSNMS 295
               |||::.     |.:..:...|..:..|.:         :.::::..:..|  :||:......
Human   407 CGKAFSMHS-----NLTKHQIIHTGEKPFKCN---------ECVKVFTQYSHL--ANHRRIHTGE 455

  Fly   296 SRKQAYESMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYAGSTAEKFYLEVCRFMPAKM 360
            ...:..|...|              |....:|      .|..||:.|.               |.
Human   456 KPYRCDECGKA--------------FSVRSSL------TTHQAIHTGE---------------KP 485

  Fly   361 YKQRLVCEFCHQITSSDHVLQSHIFKAHNIGELPFKCTLCDRSFVGRCELANHIQRVHIG-KTHK 424
            ||    |..|.::.:.:..|.||  :..:.||.|:||..|.::|....:||.| .|||.| |.:|
Human   486 YK----CNDCGKVFTQNSHLASH--RGIHSGEKPYKCDECGKAFSQTSQLARH-WRVHTGEKPYK 543

  Fly   425 CTHCERSFAVMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPKDF 489
            |..|.::|:|.|.|.:|...|||.|||.|..|||.||..|.:.:| ..|||..:.:||..|.|.|
Human   544 CNECGKAFSVHSSLTIHQTIHTGQKPYKCNDCGKVFRHNSYLAIH-QRIHTGEKPYKCNECGKAF 607

  Fly   490 VKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKLCDSRFSQFVGLNTH 554
            ....:|:.|...|...:...|:.|||.||....|..||:||:..|.:.|..|...||....|.||
Human   608 SVHSNLATHQVIHTGEKPYKCNECGKVFTQNSHLANHRRIHTGEKPYRCNECGKAFSVRSTLTTH 672

  Fly   555 M 555
            |
Human   673 M 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	19/77 (25%)
		MADF_DNA_bdg	273..356	CDD:287510	11/82 (13%)
		C2H2 Zn finger	367..388	CDD:275368	5/20 (25%)
		C2H2 Zn finger	397..418	CDD:275368	7/20 (35%)
		COG5048	<423..554	CDD:227381	50/130 (38%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..460	CDD:290200	12/22 (55%)
		C2H2 Zn finger	453..470	CDD:275368	7/16 (44%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..559	CDD:275368	8/18 (44%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	74/295 (25%)
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368
		C2H2 Zn finger	348..368	CDD:275368	4/19 (21%)
		C2H2 Zn finger	376..396	CDD:275368	5/19 (26%)
		C2H2 Zn finger	404..424	CDD:275368	4/24 (17%)
		C2H2 Zn finger	432..452	CDD:275368	3/30 (10%)
		C2H2 Zn finger	460..480	CDD:275368	6/39 (15%)
		C2H2 Zn finger	488..508	CDD:275368	5/21 (24%)
		C2H2 Zn finger	516..536	CDD:275368	7/20 (35%)
		C2H2 Zn finger	544..564	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	8/20 (40%)
		zf-H2C2_2	584..608	CDD:316026	8/24 (33%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:316026	8/24 (33%)
		C2H2 Zn finger	628..648	CDD:275368	9/19 (47%)
		zf-H2C2_2	640..664	CDD:316026	8/23 (35%)
		C2H2 Zn finger	656..676	CDD:275368	8/18 (44%)
		zf-H2C2_2	669..693	CDD:316026	4/5 (80%)
		C2H2 Zn finger	684..704	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930