DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1602 and ZNF208

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	405	Identity:	114/405 - (28%)
Similarity:	156/405 - (38%)	Gaps:	117/405 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 YKEHPC----LWNPAHSDYK------EPKKCKEALKRMAIDLEATVSVFLNEMALKLAIKKVHMQ 215
            ||...|    .|:...|.:|      :|.||:|..|.            .|:.|:.:.
Human   553 YKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKA------------FNQSAILIK------- 598

  Fly   216 FNTVHKRVVSGKQKPQSLAFSIYKLCCFLNASNDEEGATNNEKIKLDFSKKNKLTTDLIEMYANF 280
                |||:.:| :||       ||  |      :|.|.|        |||.:.|||
Human   599 ----HKRIHTG-EKP-------YK--C------EECGKT--------FSKVSTLTT--------- 626

  Fly   281 PQLYDSNHKEFSNMSSRKQAYESMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYAGSTA 345
                   ||.........:..|.....|.|..:                    .|..||:||.
Human   627 -------HKAIHAGEKPYKCKECGKTFIKVSTL--------------------TTHKAIHAGE-- 662

  Fly   346 EKFYLEVCRFMPAKMYKQRLVCEFCHQITSSDHVLQSHIFKAHNIGELPFKCTLCDRSFVGRCEL 410
                         |.||    |:.|.:..|...:|..|  |..:.||.|:||..|.::|.....|
Human   663 -------------KPYK----CKECGKAFSKFSILTKH--KVIHTGEKPYKCEECGKAFNWSSNL 708

  Fly   411 ANHIQRVHIG-KTHKCTHCERSFAVMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIH 474
            ..| :|:|.| |.:||..|.:||:..|.|..|...|||.|||.||.||||::..|.::.| ..||
Human   709 MEH-KRIHTGEKPYKCEECGKSFSTFSVLTKHKVIHTGEKPYKCEECGKAYKWSSTLSYH-KKIH 771

  Fly   475 TKIRAFKCTMCPKDFVKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCK 539
            |..:.:||..|.|.|.:...|..|.:.|.:.:...|..|||.|:....|..|:.||:..|.:.||
Human   772 TVEKPYKCEECGKAFNRSAILIKHKRIHTDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCK 836

  Fly   540 LCDSRFSQFVGLNTH 554
            .|...||:|..|..|
Human   837 ECGKAFSKFSILTKH 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	22/92 (24%)
		MADF_DNA_bdg	273..356	CDD:287510	10/82 (12%)
		C2H2 Zn finger	367..388	CDD:275368	6/20 (30%)
		C2H2 Zn finger	397..418	CDD:275368	6/20 (30%)
		COG5048	<423..554	CDD:227381	50/130 (38%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..460	CDD:290200	13/22 (59%)
		C2H2 Zn finger	453..470	CDD:275368	7/16 (44%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..559	CDD:275368	8/17 (47%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381	25/112 (22%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		zf-H2C2_2	511..536	CDD:290200
		C2H2 Zn finger	527..547	CDD:275368
		C2H2 Zn finger	555..575	CDD:275368	4/19 (21%)
		zf-H2C2_2	568..592	CDD:290200	7/35 (20%)
		C2H2 Zn finger	583..603	CDD:275368	8/42 (19%)
		zf-H2C2_2	596..619	CDD:290200	12/57 (21%)
		C2H2 Zn finger	611..631	CDD:275368	12/49 (24%)
		C2H2 Zn finger	639..659	CDD:275368	5/39 (13%)
		C2H2 Zn finger	667..687	CDD:275368	6/21 (29%)
		COG5048	691..1133	CDD:227381	62/163 (38%)
		C2H2 Zn finger	695..715	CDD:275368	6/20 (30%)
		zf-H2C2_2	707..732	CDD:290200	11/25 (44%)
		C2H2 Zn finger	723..743	CDD:275368	7/19 (37%)
		C2H2 Zn finger	751..771	CDD:275368	8/20 (40%)
		zf-H2C2_2	764..788	CDD:290200	9/24 (38%)
		C2H2 Zn finger	779..799	CDD:275368	6/19 (32%)
		C2H2 Zn finger	807..827	CDD:275368	7/19 (37%)
		C2H2 Zn finger	835..855	CDD:275368	8/17 (47%)
		C2H2 Zn finger	863..883	CDD:275368
		zf-H2C2_2	876..899	CDD:290200
		C2H2 Zn finger	891..911	CDD:275368
		C2H2 Zn finger	919..939	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..995	CDD:275368
		C2H2 Zn finger	1003..1023	CDD:275368
		zf-H2C2_2	1015..1039	CDD:290200
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1059..1079	CDD:275368
		C2H2 Zn finger	1087..1107	CDD:275368
		zf-H2C2_2	1099..1124	CDD:290200
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142421
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840