DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1602 and ZBTB16

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001018011.1	Gene:	ZBTB16 / 7704	HGNCID:	12930	Length:	673	Species:	Homo sapiens

Alignment Length:	527	Identity:	114/527 - (21%)
Similarity:	186/527 - (35%)	Gaps:	140/527 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VGENSTESGHVD--PPEEKPQAEESIFQ-------QDESADGACVQLHIDAVRSSTNETEESDVS 111
            |.|..||...||  |.::.|.|.||...       ::...:|.........:.|:.        .
Human   238 VAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSAR--------E 294

  Fly   112 LVTDEEESVQDEDPSEPALDDANLKTTPTYKFHPSFFRRDHRTIKFIEIYKEHPCLWNPAHSDYK 176
            |....|||.:...|      .|.....||.:                   .|||.
Human   295 LHYGREESAEQVPP------PAEAGQAPTGR-------------------PEHPA---------- 324

  Fly   177 EPKKCKEALKRMAIDLEATVSVFLNEMALKLAIKKVHMQFNTVHKRVVSGKQKPQSLAFSIYKLC 241
            .|.:     |.:.|     .||..|..|..:.         ::...|.||.....:||
Human   325 PPPE-----KHLGI-----YSVLPNHKADAVL---------SMPSSVTSGLHVQPALA------- 363

  Fly   242 CFLNASNDEEGATNNEKIKLDFSKKNKLTTDLIEMYANFPQLYDSNHKEFSNMS----SRKQAYE 302
                             :.:|||....|          .||.: ...:.||.:.    ..|....
Human   364 -----------------VSMDFSTYGGL----------LPQGF-IQRELFSKLGELAVGMKSESR 400

  Fly   303 SMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYAGSTAEKFYLEVC--RFMPAKMYKQRL 365
            ::..:.||..|::..::   |::..|:.:           |..:.:..|:|  ||:.:...:..|
Human   401 TIGEQCSVCGVELPDNE---AVEQHRKLH-----------SGMKTYGCELCGKRFLDSLRLRMHL 451

  Fly   366 ----------VCEFCHQITSSDHVLQSHIFKAHNIGELPFKCTLCDRSFVGRCELANHIQRVHIG 420
                      ||:.|....|.:..|::| .:.|...::...|.||.:.|..:..|..|:: ||.|
Human   452 LAHSAGAKAFVCDQCGAQFSKEDALETH-RQTHTGTDMAVFCLLCGKRFQAQSALQQHME-VHAG 514

  Fly   421 -KTHKCTHCERSFAVMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTM 484
             :::.|:.|.|:|...:.|:.|:|:|||..||.||.||..||..|.:..| ..|||..:.::|..
Human   515 VRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSH-KRIHTGEKPYECNG 578

  Fly   485 CPKDFVKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKLCDSRFSQFV 549
            |.|.|..|..|..|.:.|...:...|.:|.:......|:|:|.:.|:....:.|.:|........
Human   579 CGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLS 643

  Fly   550 GLNTHMK 556
            .:..|||
Human   644 SMQKHMK 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	15/86 (17%)
		MADF_DNA_bdg	273..356	CDD:287510	14/88 (16%)
		C2H2 Zn finger	367..388	CDD:275368	5/20 (25%)
		C2H2 Zn finger	397..418	CDD:275368	6/20 (30%)
		COG5048	<423..554	CDD:227381	39/130 (30%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..460	CDD:290200	12/22 (55%)
		C2H2 Zn finger	453..470	CDD:275368	7/16 (44%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	5/19 (26%)
		C2H2 Zn finger	538..559	CDD:275368	5/19 (26%)
ZBTB16	NP_001018011.1	BTB	25..125	CDD:306997
		Herpes_ICP4_C	177..>327	CDD:332854	24/131 (18%)
		Interaction with RUNX1T1. /evidence=ECO:0000269\|PubMed:10688654	200..300		14/69 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..236
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..332		21/130 (16%)
		C2H2 Zn finger	406..426	CDD:275368	5/22 (23%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		COG5048	<448..622	CDD:227381	53/176 (30%)
		C2H2 Zn finger	463..483	CDD:275368	5/20 (25%)
		C2H2 Zn finger	492..512	CDD:275368	6/20 (30%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	8/20 (40%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	5/19 (26%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100