DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1602 and ZNF84

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	581	Identity:	143/581 - (24%)
Similarity:	221/581 - (38%)	Gaps:	116/581 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MEDDFEP-VGENSTESGHVDPPE-----------EKPQAEESIFQQDESAD--GACVQLHIDAV- 98
            :|...|| ||:....|.  |.||           :..|.:..|.::....|  |....|:::.|
Human    60 LEQGEEPWVGDGEIPSS--DSPEVWKVDGNMMWHQDNQDKLKIIKRGHECDAFGKNFNLNMNFVP 122

  Fly    99 -RSSTNETEESDVSLVTDEEESVQDEDPSEPALDDANLKTTPTYKFHPSFFRRDHRTIKFIEIYK 162
             |.|.:|.:...:.|....:..:...|..:...||.|:        ..:||...
Human   123 LRKSNSEGDLDGLILKHHLDLLIPKGDYGKAESDDFNV--------FDNFFLHS----------- 168

  Fly   163 EHPCLWNPAHSD----YKEPKKCKEALKRMAIDLEATVSVFLNEMALKL----------AIKKVH 213
                  .|..:|    |.:..|.||:.|:..|     :....|.:..||          :.|...
Human   169 ------KPEDTDTWLKYYDCDKYKESYKKSQI-----IIYHRNRLGEKLYECSECRKRFSKKPSL 222

  Fly   214 MQFNTVHKRVVS------GKQKPQSLAFSIYKLCCFLNASNDEEGATNNEKIKLDFSKKNKLTTD 272
            ::..:.|.|.::      ||..||...|..:      :.::..|...|..:....||:|::||:.
Human   223 IKHQSRHIRDIAFGCGNCGKTFPQKSQFITH------HRTHTGEKPYNCSQCGKAFSQKSQLTSH 281

  Fly   273 LIEMYANFPQLYDSNHKEFSNMSSRKQAYESMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKH 337
            ........|.......|.||..|.....:.:...|     .....::..||.............|
Human   282 QRTHTGEKPYECGECGKAFSRKSHLISHWRTHTGE-----KPYGCNECGRAFSEKSNLINHQRIH 341

  Fly   338 AIYAGSTAEK-FYLEVCRFMPAKMY--KQRLV-------------CEFCHQITSSDHVLQSHIFK 386
                  |.|| |....|    .|.:  |.:||             |..|.:.......|..|  :
Human   342 ------TGEKPFECREC----GKAFSRKSQLVTHHRTHTGTKPFGCSDCRKAFFEKSELIRH--Q 394

  Fly   387 AHNIGELPFKCTLCDRSFVGRCELANHIQRVHIG-KTHKCTHCERSFAVMSDLQLHIRTHTGHKP 450
            ..:.||.|::|:.|.::|..|..|.|| ||.|.| |.|.|..|.::|:..|.|..|..||||.||
Human   395 TIHTGEKPYECSECRKAFRERSSLINH-QRTHTGEKPHGCIQCGKAFSQKSHLISHQMTHTGEKP 458

  Fly   451 YVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPKDFVKKVDLSDHIKGHLNIRDKICSVCGK 515
            ::|..|||||..:||:..| ...||..:.::|:.|.|.|.:|:.|::|.:.|...:..:||.|||
Human   459 FICSKCGKAFSRKSQLVRH-QRTHTGEKPYECSECGKAFSEKLSLTNHQRIHTGEKPYVCSECGK 522

  Fly   516 GFTSCHALIRHRQIHSEVKKFVCKLCDSRFSQFVGLNTHMKRTHNILRNNSQKGKDAVDAE 576
            .|.....||.|::.|:..|.:.|..|...|.:...|.|| :|||     ..:|..:..|.|
Human   523 AFCQKSHLISHQRTHTGEKPYECSECGKAFGEKSSLATH-QRTH-----TGEKPYECRDCE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	19/106 (18%)
		MADF_DNA_bdg	273..356	CDD:287510	14/83 (17%)
		C2H2 Zn finger	367..388	CDD:275368	4/20 (20%)
		C2H2 Zn finger	397..418	CDD:275368	9/20 (45%)
		COG5048	<423..554	CDD:227381	47/130 (36%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..460	CDD:290200	12/22 (55%)
		C2H2 Zn finger	453..470	CDD:275368	8/16 (50%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..559	CDD:275368	7/20 (35%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630	3/7 (43%)
		C2H2 Zn finger	209..229	CDD:275368	1/19 (5%)
		C2H2 Zn finger	237..257	CDD:275368	5/25 (20%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		zf-H2C2_2	278..302	CDD:316026	5/23 (22%)
		C2H2 Zn finger	293..313	CDD:275368	4/19 (21%)
		COG5048	317..724	CDD:227381	86/281 (31%)
		C2H2 Zn finger	321..341	CDD:275368	2/19 (11%)
		C2H2 Zn finger	349..369	CDD:275368	5/23 (22%)
		C2H2 Zn finger	377..397	CDD:275368	4/21 (19%)
		C2H2 Zn finger	405..425	CDD:275368	9/20 (45%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..481	CDD:275368	9/20 (45%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	9/19 (47%)
		C2H2 Zn finger	545..565	CDD:275368	7/20 (35%)
		C2H2 Zn finger	573..593	CDD:275368	2/5 (40%)
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840