DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1602 and Zfp689

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_780372.2	Gene:	Zfp689 / 71131	MGIID:	1918381	Length:	500	Species:	Mus musculus

Alignment Length:	513	Identity:	118/513 - (23%)
Similarity:	171/513 - (33%)	Gaps:	160/513 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DDFEPVGENSTESGHVDPPEEKPQAEESIFQQDESADGACVQLHIDAVRSSTNETEESDVSLVTD 115
            ||:||..        :||.|.:...   .||:.               ..|..:|||.||....:
Mouse    86 DDWEPAA--------LDPQEYRRWV---TFQRK---------------TRSKQKTEEKDVFPPKE 124

  Fly   116 -EEESVQDEDPSEPALDDANLKTTP-------TYKFHPSFFRRDHRTIKFIEIYKEHPCLWNPAH 172
             ..:..:...||:|.|........|       |:.        ||..:      :.|.|..|
Mouse   125 APRKGKRGRKPSKPRLIPRQTSGGPICPDCGCTFP--------DHLAL------ESHKCAQN--- 172

  Fly   173 SDYKEPKKCKEALKRMAIDLEATVSVFLNEMALKLAIKKVHMQFNTVHKRVVSGKQKPQSLAFSI 237
              .|:|..|.:..:|.:..     |:.::                  |:|..||:
Mouse   173 --LKKPYPCPDCGRRFSYP-----SLLVS------------------HRRAHSGE---------- 202

  Fly   238 YKLCCFLNASNDEEGATNNEKIKLDFSKKNKLTTDLIEMYANFPQLYDSNHKEFSNMSSRKQAYE 302
                |                                      |.:.|...|.|   |.||..
Mouse   203 ----C--------------------------------------PYVCDQCGKRF---SQRKNL-- 220

  Fly   303 SMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYAGSTAEKFYLEVCRFMPAKMYKQRLVC 367
            |....|.......:..|..|..:..|......|.|      |.||         |.:       |
Mouse   221 SQHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTH------TGEK---------PHQ-------C 263

  Fly   368 EFCHQITSSDHVLQSHIFKAHNIGELPFKCTLCDRSFVGRCELANHIQRVHIG-KTHKCTHCERS 431
            ..|.:..:...:|..|  :..:.||.|:.|..|.|.|..|..|..| ||:|.| |.:.|..|||.
Mouse   264 PSCGRRFAYPSLLAIH--QRTHTGEKPYTCLECSRRFRQRTALVIH-QRIHTGEKPYPCPDCERR 325

  Fly   432 FAVMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPKDFVKKVDLS 496
            |:..|.|..|.|.|:|.:||.||:|...|..||.:..| ..:||..:.:.|..|.:.|.:...|:
Mouse   326 FSSSSRLVSHRRVHSGERPYACENCEARFSQRSTLLQH-QLLHTGEKPYPCPDCGRAFRRSGSLA 389

  Fly   497 DHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKLCDSRFSQFVGLNTH 554
            .|...|...:...|..||:.|.....|..||::||..:.:.|.||..||:|:..|:.|
Mouse   390 IHRSTHTEEKLHACDDCGRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLSQH 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	13/86 (15%)
		MADF_DNA_bdg	273..356	CDD:287510	17/82 (21%)
		C2H2 Zn finger	367..388	CDD:275368	4/20 (20%)
		C2H2 Zn finger	397..418	CDD:275368	9/20 (45%)
		COG5048	<423..554	CDD:227381	44/130 (34%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		zf-H2C2_2	437..460	CDD:290200	10/22 (45%)
		C2H2 Zn finger	453..470	CDD:275368	6/16 (38%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..559	CDD:275368	8/17 (47%)
Zfp689	NP_780372.2	KRAB	29..88	CDD:214630	1/1 (100%)
		KRAB	29..68	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..144		11/53 (21%)
		C2H2 Zn finger	151..171	CDD:275368	5/33 (15%)
		COG5048	171..>466	CDD:227381	93/388 (24%)
		C2H2 Zn finger	179..199	CDD:275368	5/42 (12%)
		C2H2 Zn finger	207..227	CDD:275368	7/24 (29%)
		zf-H2C2_2	219..244	CDD:290200	4/26 (15%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		zf-H2C2_2	247..272	CDD:290200	8/46 (17%)
		C2H2 Zn finger	263..283	CDD:275368	4/21 (19%)
		zf-H2C2_2	276..300	CDD:290200	9/25 (36%)
		C2H2 Zn finger	291..311	CDD:275368	9/20 (45%)
		zf-H2C2_2	303..328	CDD:290200	12/25 (48%)
		C2H2 Zn finger	319..339	CDD:275368	9/19 (47%)
		zf-H2C2_2	332..356	CDD:290200	11/23 (48%)
		C2H2 Zn finger	347..367	CDD:275368	7/20 (35%)
		zf-H2C2_2	360..384	CDD:290200	6/24 (25%)
		C2H2 Zn finger	375..395	CDD:275368	5/19 (26%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..440	CDD:290200	10/23 (43%)
		C2H2 Zn finger	431..451	CDD:275368	8/17 (47%)
		C2H2 Zn finger	459..475	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930