DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1602 and CG2199

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	121/815 - (14%)
Similarity:	225/815 - (27%)	Gaps:	376/815 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LICVSRDYEKFLMRCSYCPTDV---------------EVAQWQEFVLHIRNVHS----------- 44
            |:|.:....:..:||.:|.|..               ::....|.:.| |::.|
  Fly     5 LLCENMTKVQKEVRCDHCGTSQGSKSVFSGQKVFLGRKITDVLETITH-RSIPSSLPIKICFVCT 68

  Fly    45 -----------KVRSMEDDFEPVGENSTESGHVDPPEEK---------PQAEESIFQQDES---- 85
                       |||...|..:......|:...::.|..:         |:...::.|:.:|
  Fly    69 STFMSSAALIEKVRETVDRVQEQPAKKTKVAEIEEPSTQESDKKAVKVPKKNTTLRQRSKSIAAF 133

  Fly    86 ----ADGACVQLHIDAVRSSTNETEE--------------------------------------- 107
                .:||.....|:.:.:|..:.::
  Fly   134 PPSFVNGANTNTEIEIISASPKKLDKTPKKQISRLFEDNLNDSVKLTPAKEVSSTKKAFLNLFGN 198

  Fly   108 --SDVSLVTDEEESVQDEDPSEPALDDANLKTTPTYKFHPSFFRRDHRTIKFIEIYKEH------ 164
              :|...|..|.|..:|.|.....::..|.: .|..:||          .||.:.||||
  Fly   199 GGNDAIEVLTESEEEEDSDKGPITINTNNFQ-CPECEFH----------AKFPKPYKEHLQKEHG 252

  Fly   165 -------PC------------LWN---PAHS---DYKEPKKCKEALKRMA-------IDLEATVS 197
                   ||            |.|   ..||   :.:...|.||:.::.|       ||.:|.
  Fly   253 LQRPRIYPCTLCIKTFGVLKTLKNHLRDTHSRTFESEAKTKAKESKEKEAKSGAKNKIDAKAK-- 315

  Fly   198 VFLNEMALKLAIKKVHMQFNTVHKRVVSGKQKPQSLAFSIYKLCCFLNASNDEEGATNNEKIKLD 262
                                  ....||.::||                   :|..:..:|.::.
  Fly   316 ----------------------ETNAVSQRKKP-------------------KEKKSKEKKTEIK 339

  Fly   263 FSKKNKLTTDLIEMYAN--FPQLYDSNHKEFSNMSSRKQAYESMAAEISVPNVDINSDDIFRAIQ 325
            .:.:.|:..::.:...|  .....|::..:.:.::|.|...||:..:..:.|| |:|:..| ||
  Fly   340 CNVETKVVDEIDDQVNNKKGTDSEDADQTQATKIASFKALNESLMKKRMLENV-IDSEYTF-AI- 401

  Fly   326 NLRQWYYKNTKHAIYAGSTAEKFYLEVCRFMPAKMYKQRLVCEFCHQITSSDHVLQSHIFKAHNI 390
                    |...|....:.:..|..|:|.               |..:|:..  :|.|:...|:|
  Fly   402 --------NGSSASTPRADSNNFQCEICD---------------CELMTAKQ--MQEHMKTVHSI 441

  Fly   391 GELP--FKCTLCDRS-------------------------------------FVGRCELANHIQR 416
             :.|  |||.:|::|                                     .:|..::.|..::
  Fly   442 -DKPKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPNSSKRKILQDEDEDVDILGTTQIENTAEK 505

  Fly   417 VH--------------------------------------------------------------- 418
            |.
  Fly   506 VEGPKKSQQSPTKAAKFTNRKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRSRNNIQHQVD 570

  Fly   419 ---------IGKTHKCTHCERSFA-----------------------------VMSDLQLHIRTH 445
                     ..||.|.:|.:.|.:                             ::.::..::|.|
  Fly   571 GGMIAPRSPAKKTKKTSHVDLSVSTTNGNSPAKSEKRKKQDKSEDTLPSSDVDIVEEINYNVRPH 635

  Fly   446 ------------TGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPKDFVKKVDLSDH 498
                        .......|:.|||..:.|.::..|:...|.  ...:||:|.:.:..::|...|
  Fly   636 KKARLESIGDSTADESTLSCDRCGKFVKSRQRLDSHMEKKHA--AKLQCTLCKEVYQNQMDYVAH 698

  Fly   499 IKGHLNIRDKICSV--CGKGFTSCHALIRH-RQIH 530
            .....:.....|.|  |.|.||..:.|..| |:.|
  Fly   699 FSNCGSEGGLPCGVANCKKVFTEANFLSSHLRKRH 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	22/124 (18%)
		MADF_DNA_bdg	273..356	CDD:287510	18/84 (21%)
		C2H2 Zn finger	367..388	CDD:275368	4/20 (20%)
		C2H2 Zn finger	397..418	CDD:275368	5/57 (9%)
		COG5048	<423..554	CDD:227381	27/152 (18%)
		C2H2 Zn finger	425..445	CDD:275368	3/48 (6%)
		zf-H2C2_2	437..460	CDD:290200	6/34 (18%)
		C2H2 Zn finger	453..470	CDD:275368	5/16 (31%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	9/22 (41%)
		C2H2 Zn finger	538..559	CDD:275368
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	6/37 (16%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930