DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1602 and zf30C

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster

Alignment Length:	662	Identity:	138/662 - (20%)
Similarity:	244/662 - (36%)	Gaps:	172/662 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CGLICVSRDYEKFLMRCSYCPTDVEVAQWQEFVLHIRNVHSKVRSMED-----DFEPVGENSTES 63
            ||...:.|: |...|.|..|.|....|.         |:....||..|     :::..|.:....
  Fly   119 CGEEKLPRE-ESRPMECKCCYTRFSSAS---------NLSKHRRSRPDTCGQPEYDSPGSSDGMK 173

  Fly    64 GHV---------DPPEEKPQAEESIFQQDESADGACVQLHIDAVRSSTNETEESDVSLVTDEEES 119
            .|.         |..:|...:|||   :|...|   :.|   |.|..|...:||..|   |..:.
  Fly   174 KHKAFRKKDRNRDSDDEDTTSEES---EDSDDD---IPL---ASRLKTKLKQESQNS---DSGDE 226

  Fly   120 VQDEDP--SEPALDDANLKTTPTYKFHPSFFRRDHRTIKFIEIYKEHPCLWNPAHSDYKEPKKCK 182
            ..|.:|  ||...|.:..:..|     |:..:        :|.:.|....:..|....|     .
  Fly   227 CPDFEPNNSEDDADASGFQLPP-----PAMVK--------VEAFDEEDFEYQDASMYVK-----T 273

  Fly   183 EALKRMAIDLEATVSVFLNE-------MALKL-----------AIKKVHMQFNTV---------- 219
            |:....:.:.:..:.|.|||       .:||:           |:..|.:....|
  Fly   274 ESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEK 338

  Fly   220 ----HKRVVSGKQKPQSLAFSIYKLCCFLNASNDEEGATNNEKIKLDFSKK---------NKLTT 271
                .||....|:|...:.....|.....:.|.|:...|.....|:  |||         ||:..
  Fly   339 PPGPRKRGRPPKEKIPVVKRKYRKRNAPRSPSPDDSSGTPKRVAKI--SKKELKERLKMINKMEK 401

  Fly   272 D-----LIEMYANFPQLYD----SNHKEFSNMSSRKQAYESMAAEISVPNVDINS---DDIFRA- 323
            .     .:::| :..:.|:    .:||  .|.:..|:.::         :||:::   :::|:.
  Fly   402 SWKCPHCVKIY-HIRKPYEKHLRDDHK--LNEAEMKEIFK---------DVDVHAKLDEEVFKCP 454

  Fly   324 -IQNLRQWYYKNTKHAIYAGSTAEKFYLEVC---RFMPAK---------MYKQRLVCEFCHQITS 375
             ...:.....:...|....|...:..:...|   .|...|         .:|:.|.||.|.:..:
  Fly   455 ICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLYCEKCDKYMT 519

  Fly   376 SDHVLQSHIFKAHNIGELPFK-----CTLCDRSFVGRCELANHIQRVHIGK--THKCTHCERSFA 433
            ....|::|....|:..|...:     |..|.:.|.||..|::|: |...|:  .:.|:.|.:..:
  Fly   520 GHDSLKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHV-RSDCGRLPLYGCSVCGKHLS 583

  Fly   434 VMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPKDFVKKVDLSDH 498
            ....|:.|:..|....||.|:.|||.|::::|...|:...||..:.:||.:|||::..:..|..|
  Fly   584 TAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTH 648

  Fly   499 IKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKLC-----DSRFSQFVGLNTHMKRT 558
            :..|..|:..:|:.|||.||....|..||::|::.       |     :::.:|::|:
  Fly   649 MTVHTGIKRFLCNNCGKRFTCISNLQAHRKVHADT-------CGQLPLNAKATQYMGV------- 699

  Fly   559 HNILRNNSQKGK 570
                    |:||
  Fly   700 --------QRGK 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	19/118 (16%)
		MADF_DNA_bdg	273..356	CDD:287510	12/94 (13%)
		C2H2 Zn finger	367..388	CDD:275368	5/20 (25%)
		C2H2 Zn finger	397..418	CDD:275368	8/20 (40%)
		COG5048	<423..554	CDD:227381	38/135 (28%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		zf-H2C2_2	437..460	CDD:290200	9/22 (41%)
		C2H2 Zn finger	453..470	CDD:275368	6/16 (38%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..559	CDD:275368	3/25 (12%)
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368
		C2H2 Zn finger	98..117	CDD:275368
		C2H2 Zn finger	134..152	CDD:275368	5/26 (19%)
		C2H2 Zn finger	511..532	CDD:275370	5/20 (25%)
		COG5048	<523..>672	CDD:227381	44/149 (30%)
		C2H2 Zn finger	546..566	CDD:275368	8/20 (40%)
		C2H2 Zn finger	575..595	CDD:275368	4/19 (21%)
		C2H2 Zn finger	603..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930