DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1602 and CG8944

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	160/752 - (21%)
Similarity:	274/752 - (36%)	Gaps:	207/752 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CGLICVSRDYEKFLMRCSYCPTDVEVAQWQEFVLHIRNVHSKVRSMEDDFE----PVGENSTESG 64
            ||::..:.|::.|.:||.:|  ..:...:..|:.|::.||...:|:.:...    .:||..:.||
  Fly    22 CGMVTATDDFQYFALRCIFC--SEKFLYFDSFIGHMQTVHLGDQSVANTSSRLPFNLGEPMSLSG 84

  Fly    65 -HVDPP-----EEKPQAEESIFQ-----QDESADGACVQLHI-------DAVRSSTNETE----- 106
             :.|.|     |:...|:.::.:     :.|..|..|....:       |..|.:.:|.:
  Fly    85 RNGDLPNFHEIEDLTDADTALLEPQMVIKQELQDLPCSDDDVVAGEEDDDEQRLNDSEADEDEAI 149

  Fly   107 --ESDVSLVT-------------------------DEEESVQD-EDPSEPALDDANLKTTPTYKF 143
              ||||.:|:                         |.:.|:.| .||....:||.:.:......|
  Fly   150 LPESDVPVVSSKTRARKKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEYMDFAGF 214

  Fly   144 ----HPSF--------------------------FRRDHRTIKF-IEIYKEHPCLWNPAHSDYKE 177
                |..|                          ..:|.:.|:| |..|:.:|.||:..::.:::
  Fly   215 DGVNHSGFGTESDFLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDHGNAQFRD 279

  Fly   178 PKKCKEALKRMAIDLEATVSVFLNEMALKLAIKKVHMQFNTVHKRVVS--GKQKPQSLAFSIYKL 240
            ..|....|..:.::.::..::.|    .|.||.:......||:||..:  ..:|........:|.
  Fly   280 RVKRARFLDWIVLEFKSRFNISL----AKDAITRKWDNLRTVYKRECNRMALEKTNISTLWYFKE 340

  Fly   241 CCFLN---ASNDE--EGATNNEKIKLDFSK--KNKLTTDLIEMYANFPQLYDSNHKEFSNMSSRK 298
            ..|||   :.||:  :........:..||.  .:..|..|:.|...:...|:....::.:...|.
  Fly   341 LHFLNEVYSYNDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNRFDPDYRSKERRG 405

  Fly   299 QAYESMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYAGSTAEKF-----YLEVCRFM-- 356
            :....||.|:. ..:|:.:..|.:.|..||..|.|.....:.:....:||     |.:...||
  Fly   406 EGLHQMAIELQ-QLIDVTTIQISKRISQLRFDYSKQKMERLNSERLGKKFIANYLYYDQMHFMDD 469

  Fly   357 ---PAKMYKQRLVCEFCHQITSSDHVLQSHIFKAH--NIGELPFKCTLCDRSFVGRCELANHIQR 416
               |.|       |..|.:|..:...|..|:. .|  ::|. .:.|.:|...|....|..|| ::
  Fly   470 DIPPFK-------CAHCPEIVQTLRELDLHML-THQPSLGG-GYYCNICSIQFHNAQEFDNH-KQ 524

  Fly   417 VHIGKT----HKCTHCERSFAVMSDLQLHIRTHT----------GH------------------- 448
            :|:|..    ..|..|..||...::...|:|.|.          .|
  Fly   525 LHLGGVTEIKFNCELCTASFREKANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEES 589

  Fly   449 ------------------------------------------KPYVCEHCGKAFRLRSQMTLHVT 471
                                                      |||.|:.|.::|.....:..| .
  Fly   590 RGSGSRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAH-R 653

  Fly   472 AIH--TKIRAFKC--TMCPKDFVKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSE 532
            .:|  .:.|.:||  ..|.|.||.:..|.:|:|.|.:..:..|.:|||.|.|...|..|:|||.:
  Fly   654 IVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDK 718

  Fly   533 VKKFVCKLCDSRFSQFVGLNTHMKRTHNILRNNSQKG 569
            :|::||::|.|.|:|..||..| ||.||  |.|...|
  Fly   719 IKRYVCQICGSAFAQAAGLYLH-KRRHN--RPNGAVG 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	18/89 (20%)
		MADF_DNA_bdg	273..356	CDD:287510	17/87 (20%)
		C2H2 Zn finger	367..388	CDD:275368	5/20 (25%)
		C2H2 Zn finger	397..418	CDD:275368	6/20 (30%)
		COG5048	<423..554	CDD:227381	47/205 (23%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..460	CDD:290200	9/93 (10%)
		C2H2 Zn finger	453..470	CDD:275368	3/16 (19%)
		C2H2 Zn finger	482..502	CDD:275368	8/21 (38%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..559	CDD:275368	10/20 (50%)
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	17/88 (19%)
		MADF	379..472	CDD:214738	19/93 (20%)
		C2H2 Zn finger	476..496	CDD:275368	5/20 (25%)
		C2H2 Zn finger	506..526	CDD:275368	6/20 (30%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	4/20 (20%)
		zf-C2H2_8	639..712	CDD:292531	22/73 (30%)
		C2H2 Zn finger	666..688	CDD:275368	8/21 (38%)
		zf-C2H2	694..716	CDD:278523	9/21 (43%)
		C2H2 Zn finger	696..716	CDD:275368	9/19 (47%)
		zf-H2C2_2	708..733	CDD:290200	11/24 (46%)
		C2H2 Zn finger	724..744	CDD:275368	10/20 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440029
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012671
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930