DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1602 and Zfp553

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001347841.1	Gene:	Zfp553 / 233887	MGIID:	2384725	Length:	591	Species:	Mus musculus

Alignment Length:	343	Identity:	86/343 - (25%)
Similarity:	119/343 - (34%)	Gaps:	100/343 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 ESMAAEISVPNVDINS------DDIFRAIQNL--RQ-------------WYYKNTKHAIYAGSTA 345
            |.:|..:.|.|..:..      ||::...:.|  ||             |...:...|...|...
Mouse    25 EQLAPTLQVGNTSLKPDGIQCWDDLWDRREGLGKRQPRDPVPRILGEPRWGQGSNDRAAVCGECG 89

  Fly   346 EKFYLEVCRFMPAKMYKQR-------LVCEFC------------HQITSSDHVLQSHIFKAHNI- 390
            :.|     |.|...:..||       ..|..|            ||.|.:..       ||:.:
Mouse    90 KSF-----RQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHTGE-------KAYRVR 142

  Fly   391 ----------------GELPFKCTLCDRSFVGRCELANHIQRVHIG-KTHKCTHCERSFAVMSDL 438
                            ||.|..|..|.:||....:|..| ||.|.| |.:||..|.:.|...|..
Mouse   143 PPAPGPPKMPRSRIPAGERPTICGECGKSFRQSSDLVKH-QRTHTGEKPYKCGICGKGFGDSSAR 206

  Fly   439 QLHIRTHTG---------------------------HKPYVCEHCGKAFRLRSQMTLHVTAIHTK 476
            ..|.|||.|                           .|||:|..|||.|.|...:..|..: |..
Mouse   207 IKHQRTHRGDQLPRPVVPRRQPSPAAPAAPHRPKAQDKPYICTDCGKRFVLSCSLLSHQRS-HLG 270

  Fly   477 IRAFKCTMCPKDFVKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKLC 541
            .:.|.|.:|.|:|.:..||..|::.|...:..:|..|||||....|.::|.:.||..:...|..|
Mouse   271 PKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGQRPHACPEC 335

  Fly   542 DSRFSQFVGLNTHMKRTH 559
            :..||....|..| :.||
Mouse   336 NRSFSLSSTLLRH-RLTH 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916
		MADF_DNA_bdg	273..356	CDD:287510	14/74 (19%)
		C2H2 Zn finger	367..388	CDD:275368	6/32 (19%)
		C2H2 Zn finger	397..418	CDD:275368	8/20 (40%)
		COG5048	<423..554	CDD:227381	45/157 (29%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..460	CDD:290200	12/49 (24%)
		C2H2 Zn finger	453..470	CDD:275368	6/16 (38%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..559	CDD:275368	6/20 (30%)
Zfp553	NP_001347841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..80		4/24 (17%)
		C2H2 Zn finger	85..105	CDD:275368	6/24 (25%)
		zf-H2C2_2	97..120	CDD:316026	4/22 (18%)
		C2H2 Zn finger	113..133	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..160		3/35 (9%)
		COG5048	161..572	CDD:227381	60/195 (31%)
		C2H2 Zn finger	165..185	CDD:275368	8/20 (40%)
		C2H2 Zn finger	193..213	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..241		5/34 (15%)
		C2H2 Zn finger	248..268	CDD:275368	7/20 (35%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		C2H2 Zn finger	332..352	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..429
		C2H2 Zn finger	425..445	CDD:275368
		C2H2 Zn finger	453..538	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..512
		C2H2 Zn finger	546..566	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930