DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1602 and ZNF689

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_612456.1	Gene:	ZNF689 / 115509	HGNCID:	25173	Length:	500	Species:	Homo sapiens

Alignment Length:	515	Identity:	117/515 - (22%)
Similarity:	172/515 - (33%)	Gaps:	164/515 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DDFEPVGENSTESGHVDPPEEKPQAEESIFQQDESADGACVQLHIDAVRSSTNETEESDVSLVTD 115
            ||:||...:         |:|.|:             |..||      |.|....:..:..:...
Human    86 DDWEPAALD---------PQEYPR-------------GLTVQ------RKSRTRKKNGEKEVFPP 122

  Fly   116 EE---ESVQDEDPSEPALDDANLKTTP-------TYKFHPSFFRRDHRTIKFIEIYKEHPCLWNP 170
            :|   :..:...||:|.|........|       |:.        ||:.:      :.|.|..|
Human   123 KEAPRKGKRGRRPSKPRLIPRQTSGGPICPDCGCTFP--------DHQAL------ESHKCAQN- 172

  Fly   171 AHSDYKEPKKCKEALKRMAIDLEATVSVFLNEMALKLAIKKVHMQFNTVHKRVVSGKQKPQSLAF 235
                .|:|..|.:..:|.:..     |:.::                  |:|..||:
Human   173 ----LKKPYPCPDCGRRFSYP-----SLLVS------------------HRRAHSGE-------- 202

  Fly   236 SIYKLCCFLNASNDEEGATNNEKIKLDFSKKNKLTTDLIEMYANFPQLYDSNHKEFSNMSSRKQA 300
                  |                                      |.:.|...|.|   |.||..
Human   203 ------C--------------------------------------PYVCDQCGKRF---SQRKNL 220

  Fly   301 YESMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYAGSTAEKFYLEVCRFMPAKMYKQRL 365
              |....|.......:..|..|..:..|......|.|      |.||         |.:
Human   221 --SQHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTH------TGEK---------PHQ------ 262

  Fly   366 VCEFCHQITSSDHVLQSHIFKAHNIGELPFKCTLCDRSFVGRCELANHIQRVHIG-KTHKCTHCE 429
             |..|.:..:...:|..|  :..:.||.|:.|..|:|.|..|..|..| ||:|.| |.:.|..||
Human   263 -CPSCGRRFAYPSLLAIH--QRTHTGEKPYTCLECNRRFRQRTALVIH-QRIHTGEKPYPCPDCE 323

  Fly   430 RSFAVMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPKDFVKKVD 494
            |.|:..|.|..|.|.|:|.:||.||||...|..||.:..| ..:||..:.:.|..|.:.|.:...
Human   324 RRFSSSSRLVSHRRVHSGERPYACEHCEARFSQRSTLLQH-QLLHTGEKPYPCPDCGRAFRRSGS 387

  Fly   495 LSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKLCDSRFSQFVGLNTH 554
            |:.|...|...:...|..||:.|.....|..||::||..:.:.|.||..||:|:..|..|
Human   388 LAIHRSTHTEEKLHACDDCGRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLAQH 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	13/86 (15%)
		MADF_DNA_bdg	273..356	CDD:287510	17/82 (21%)
		C2H2 Zn finger	367..388	CDD:275368	4/20 (20%)
		C2H2 Zn finger	397..418	CDD:275368	9/20 (45%)
		COG5048	<423..554	CDD:227381	45/130 (35%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		zf-H2C2_2	437..460	CDD:290200	11/22 (50%)
		C2H2 Zn finger	453..470	CDD:275368	7/16 (44%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..559	CDD:275368	8/17 (47%)
ZNF689	NP_612456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		KRAB	29..88	CDD:214630	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..146		14/83 (17%)
		C2H2 Zn finger	151..171	CDD:275368	5/33 (15%)
		COG5048	159..>466	CDD:227381	98/414 (24%)
		C2H2 Zn finger	179..199	CDD:275368	5/42 (12%)
		C2H2 Zn finger	207..227	CDD:275368	7/24 (29%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..283	CDD:275368	4/21 (19%)
		C2H2 Zn finger	291..311	CDD:275368	9/20 (45%)
		C2H2 Zn finger	319..339	CDD:275368	9/19 (47%)
		C2H2 Zn finger	347..367	CDD:275368	8/20 (40%)
		C2H2 Zn finger	375..395	CDD:275368	5/19 (26%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..451	CDD:275368	8/17 (47%)
		C2H2 Zn finger	459..475	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930