DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1602 and LOC100365363

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_006228060.2	Gene:	LOC100365363 / 100365363	RGDID:	2319215	Length:	670	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	140/542 - (25%)
Similarity:	201/542 - (37%)	Gaps:	167/542 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 ESDV--SLVTDEEESVQDEDPSEPALDDANLKTTPTYKFH----------------PSFFRRDHR 153
            |.||  ||:...:::...|.|.:....|...:.|.:..:|                .:||||
  Rat   125 EYDVYSSLLMKGQKAAIKEKPYQCNECDKVFRYTSSLAYHRQIHTGEKLYKCVECGKAFFRR--- 186

  Fly   154 TIKFIEIYKEHPCLWNPAHSDYKEPKKCKEALKRMAIDLEATVSVFLNEMALKLAIKKVHMQFNT 218
              .::.:::.|       ||..| |.||.|..|           ||.....||
  Rat   187 --SYLLVHERH-------HSGAK-PYKCNECGK-----------VFSQNSHLK------------ 218

  Fly   219 VHKRVVSGKQKPQSLAFSIYKLCCFLNASNDEEGATNNEKIKLDFSKKNKLTTDLIEMYANFPQL 283
            .|:|:.:| :||       ||  |     ||...|         ||.::.||..|:....:.|..
  Rat   219 SHRRIHTG-EKP-------YK--C-----NDCGKA---------FSVRSNLTHHLVIHTGDKPYK 259

  Fly   284 YDSNHKEFSNMSSRKQAYESMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYAGS----- 343
            .:...|.||..||......:...|  .|........:|.:..||      ||..||:.|.
  Rat   260 CNECGKVFSQTSSLTIHRRTHTGE--KPYRCNECGKVFSSHSNL------NTHQAIHTGEKPYKC 316

  Fly   344 --------------------TAEKFY----------------LEVCRFMPAKMYKQRLVCEFCHQ 372
                                |.||.|                ..:......|.||    ||.|.:
  Rat   317 SECGKVFTQNSHLANHWRTHTGEKPYKCNECGKAFSVYSSLTTHLAIHTGEKPYK----CEECGK 377

  Fly   373 I-TSSDHVLQ-----------------SHIFKAHNI--------GELPFKCTLCDRSFVGRCELA 411
            : |.:.|:..                 .|..:..|:        ||.|:||:.|.::|..|..|.
  Rat   378 VFTQNSHLANHRGIHSGEKPYKCEECGKHFNQTSNLARHWRVHTGEKPYKCSECGKAFSVRSSLT 442

  Fly   412 NHIQRVHIG-KTHKCTHCERSFAVMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHT 475
            :| |.:|.| |.:||..|.:.|:..|.|.:|.|.|||.|||.|..|||||...|.:..| ..|||
  Rat   443 SH-QVIHTGEKPYKCAECGKVFSQTSSLSIHQRIHTGEKPYRCNECGKAFNSHSNLNTH-QVIHT 505

  Fly   476 KIRAFKCTMCPKDFVKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKL 540
            ..:.:||..|.|.|.:...|::|.:.|...:...|:.|||.|:...:|..|:.||:..|.|.|..
  Rat   506 GQKPYKCLECGKVFTQNSHLANHHRTHTGEKPYKCNECGKAFSVYSSLTTHQAIHTGEKPFKCNE 570

  Fly   541 CDSRFSQFVGLNTHM---KRTH 559
            |...|:|    |:|:   :|||
  Rat   571 CGKVFTQ----NSHLASHRRTH 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	21/86 (24%)
		MADF_DNA_bdg	273..356	CDD:287510	21/123 (17%)
		C2H2 Zn finger	367..388	CDD:275368	6/38 (16%)
		C2H2 Zn finger	397..418	CDD:275368	7/20 (35%)
		COG5048	<423..554	CDD:227381	49/130 (38%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..460	CDD:290200	13/22 (59%)
		C2H2 Zn finger	453..470	CDD:275368	7/16 (44%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..559	CDD:275368	7/23 (30%)
LOC100365363	XP_006228060.2	KRAB	8..68	CDD:214630
		SFP1	<143..221	CDD:227516	22/113 (19%)
		C2H2 Zn finger	148..168	CDD:275368	3/19 (16%)
		C2H2 Zn finger	176..196	CDD:275368	5/31 (16%)
		COG5048	200..575	CDD:227381	116/436 (27%)
		C2H2 Zn finger	204..224	CDD:275368	9/42 (21%)
		C2H2 Zn finger	232..252	CDD:275368	9/33 (27%)
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		C2H2 Zn finger	288..308	CDD:275368	6/25 (24%)
		C2H2 Zn finger	316..336	CDD:275368	0/19 (0%)
		C2H2 Zn finger	344..364	CDD:275368	0/19 (0%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	428..448	CDD:275368	7/20 (35%)
		C2H2 Zn finger	456..476	CDD:275368	7/19 (37%)
		C2H2 Zn finger	484..504	CDD:275368	8/20 (40%)
		C2H2 Zn finger	512..532	CDD:275368	6/19 (32%)
		C2H2 Zn finger	540..560	CDD:275368	7/19 (37%)
		C2H2 Zn finger	568..588	CDD:275368	7/23 (30%)
		zf-H2C2_2	580..604	CDD:404364	4/9 (44%)
		C2H2 Zn finger	596..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930