DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1602 and Zfp980

DIOPT Version :9

Sequence 1:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001096628.2	Gene:	Zfp980 / 100041379	MGIID:	3712454	Length:	645	Species:	Mus musculus

Alignment Length:	620	Identity:	156/620 - (25%)
Similarity:	231/620 - (37%)	Gaps:	149/620 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CVSRDYEKFLMRCSYCPTDVEVAQWQEFVL-----HIRNVHS---KVRSMEDDFEPVGENSTESG 64
            |:..:|||                  |.||     ||.|.|.   |..|..::...|...|:||.
Mouse    71 CICGNYEK------------------EKVLEQDTQHIVNEHGHNRKKSSKCNELRNVIHESSEST 117

  Fly    65 HVDPPEEKPQAEESIFQQDESADGACVQLHIDAVRSSTNETEESDVSL----VTDEEESVQDEDP 125
            ..:........:.|..::.::.....|..:.|.|.....   .|.:||    ..:::|..::::.
Mouse   118 PYNTNHRDATLQSSNLKRHKTGTTKEVCTYKDCVNCLKG---SSIISLNQGTHIEKKEHNRNKNL 179

  Fly   126 SEPALDDANLKTTPTY---KFHPSFFRRDHRTI-------KFIEIYKE---------HPCLWNPA 171
            .|..:...|.....||   :|...|.:.|:...       |...||.|         |..:.:..
Mouse   180 DEVLVSRQNNSEMSTYTCGEFDKCFTQSDNLQSQQRIYPGKKSYIYSESDKCFTQLSHLSIHHTI 244

  Fly   172 HSDYKEPKKCKEALKRMAIDLEATVSVFLNEMALKLAIKKVHMQFNT------------------ 218
            ||..| |.||.|..|           .|.::..|     :.|.:.:|
Mouse   245 HSGEK-PYKCSECDK-----------CFTDKFTL-----RKHQRIHTGEKPYKCNECDKCFTDKG 292

  Fly   219 ---VHKRVVSGKQKPQSLAFSIYKL--C--CFLNAS---------NDEEGATNNEKIKLDFSKKN 267
               ||:|:.:| :||       ||.  |  ||...|         :.|:....:|..|. |:.|:
Mouse   293 SLRVHQRIHTG-EKP-------YKCSECDKCFTQPSHLSIHRRIHSGEKPYKCSECDKC-FTDKS 348

  Fly   268 KLTTDLIEMYANFPQLYDSNHKEFSNMSSRKQAYESMAAEISVPNVDINSDDIFRAIQNLRQWYY 332
            .|...........|.......|.|::..|.:..:...|.|  .|......|..|....:||
Mouse   349 SLRVHQRIHTGEKPYQCSECDKCFTDKGSLRVHHRIHAGE--KPYQCSECDKCFTDKGSLR---- 407

  Fly   333 KNTKHAIYAGSTAEKFYLEVCRFMPAKMYKQRLVCEFCHQITSSDHVLQSHIFKAHNI--GELPF 395
              ..|.|:||.               |.||    |..|.:..:....|:.|    |.|  ||.|:
Mouse   408 --VHHRIHAGE---------------KPYK----CSECDKCFTHKDSLRVH----HRIHAGEKPY 447

  Fly   396 KCTLCDRSFVGRCELANHIQRVHIG-KTHKCTHCERSFAVMSDLQLHIRTHTGHKPYVCEHCGKA 459
            ||:.||:.|..:..|..| ||:|.| |.:||:.|::.|...|.|::|.|.|||.|||.|..|.|.
Mouse   448 KCSECDKCFTEKNGLRRH-QRIHTGEKPYKCSECDKCFTDKSSLRVHQRIHTGEKPYQCSECDKC 511

  Fly   460 FRLRSQMTLHVTAIHTKIRAFKCTMCPKDFVKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALI 524
            |..:..:.:| ..||...:.:||:.|.|.|..|..|..|.:.|...:...||.|.|.||...:|.
Mouse   512 FTDKGSLRVH-HRIHAGEKPYKCSECDKCFTDKGYLRVHHRIHAGEKPYKCSECDKCFTHKGSLR 575

  Fly   525 RHRQIHSEVKKFVCKLCDSRFSQFVGLNTHMKRTH 559
            .|.:||:..|.:.|..||..|::..||..| :|.|
Mouse   576 VHHRIHAGEKPYKCSECDKCFTEKNGLRRH-QRIH 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1602	NP_610291.2	GT1	157..244	CDD:304916	26/120 (22%)
		MADF_DNA_bdg	273..356	CDD:287510	15/82 (18%)
		C2H2 Zn finger	367..388	CDD:275368	4/20 (20%)
		C2H2 Zn finger	397..418	CDD:275368	8/20 (40%)
		COG5048	<423..554	CDD:227381	47/130 (36%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..460	CDD:290200	12/22 (55%)
		C2H2 Zn finger	453..470	CDD:275368	4/16 (25%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..559	CDD:275368	8/20 (40%)
Zfp980	NP_001096628.2	KRAB	28..>70	CDD:214630
		KRAB	28..67	CDD:279668
		COG5048	96..510	CDD:227381	111/474 (23%)
		C2H2 Zn finger	197..217	CDD:275368	3/19 (16%)
		C2H2 Zn finger	229..245	CDD:275368	1/15 (7%)
		C2H2 Zn finger	253..273	CDD:275368	6/35 (17%)
		zf-H2C2_2	266..289	CDD:290200	3/27 (11%)
		C2H2 Zn finger	281..301	CDD:275368	3/19 (16%)
		zf-H2C2_2	293..318	CDD:290200	11/32 (34%)
		C2H2 Zn finger	309..329	CDD:275368	4/19 (21%)
		C2H2 Zn finger	337..357	CDD:275368	5/20 (25%)
		zf-H2C2_2	349..373	CDD:290200	3/23 (13%)
		C2H2 Zn finger	365..385	CDD:275368	3/19 (16%)
		C2H2 Zn finger	393..413	CDD:275368	5/25 (20%)
		C2H2 Zn finger	421..441	CDD:275368	5/23 (22%)
		C2H2 Zn finger	449..469	CDD:275368	8/20 (40%)
		zf-H2C2_2	462..485	CDD:290200	10/23 (43%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		zf-H2C2_2	489..513	CDD:290200	12/23 (52%)
		C2H2 Zn finger	505..525	CDD:275368	5/20 (25%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368	8/20 (40%)
		zf-H2C2_2	602..626	CDD:290200	4/9 (44%)
		C2H2 Zn finger	617..634	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000