DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1603 and Zfp52

DIOPT Version :9

Sequence 1:	NP_001260778.1	Gene:	CG1603 / 35683	FlyBaseID:	FBgn0033185	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001014180.1	Gene:	Zfp52 / 361487	RGDID:	1359149	Length:	755	Species:	Rattus norvegicus

Alignment Length:	662	Identity:	139/662 - (20%)
Similarity:	237/662 - (35%)	Gaps:	183/662 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YCSIESELKDWELFIVHVKSAHYCEDEDVRINEIKEDTEELYSVVDAADPAIAYGPD-----EFF 81
            ||..|:..:       |||:    |.|..:.||:.|               :..||.     :..
  Rat    87 YCICETVHQ-------HVKT----EKESCQCNELGE---------------MLRGPSNCALYKRS 125

  Fly    82 EVIENSNGV----DQWMEADSKD-IQYEEDATAWSAATNNSWEFGPGGSSLELPAG-KEVTQMDE 140
            :.||.||..    |:....||.: .|:....|.....|:.:.|     .|..|.:. :|..::..
  Rat   126 DTIETSNNCRCCKDRGASVDSSNPDQHTSTHTGEEPCTSKNCE-----KSFSLCSNIREDQRLYT 185

  Fly   141 SSQNHIPLNTDDDDVDCSDFFMSEDDLAPPR-KPGRPPRRTRPGQVFKFKVSFIRSNPRVLHLIQ 204
            :.:.|     ..|:.|  |.|.|...|.... ..|..|.:..|.:.:....|.:..:.|:....:
  Rat   186 AKKEH-----KQDEYD--DRFSSTYSLMQQTVDMGEKPHQCGPCRKYINTTSSLSLHQRIHTGEK 243

  Fly   205 AYKEHPC-----LWNP---------SDEHYQDEPARSMAYEAIMERMDRKANV---LFTVEELKK 252
            .||.:.|     .|:.         |::.|:.:..|....:....:..::.:.   .:..:|..:
  Rat   244 PYKCNICEKSFNQWSRLKTHQILHISEKQYKCKEGRMSFVQVFAHKSHQRRHTGEKPYKCKECDR 308

  Fly   253 TL---------EQLH---VQYTLALETKQRGKLVGLAARYFAKCEFLS----VAPVVTPRENEED 301
            :.         :::|   |.|    |.|:.||.       |::...|.    :..|..|...||.
  Rat   309 SFAHCASLRWHQKIHSPEVHY----ECKECGKA-------FSELSHLKMHYRIHTVEKPYRYEEC 362

  Fly   302 NDLTAIKLNFKEENLITT-----------------SFIETYANYPVLYNQALPDFGSIEIRADAF 349
            :..:.:....|....|.|                 |::.||
  Rat   363 DTSSTVNSTLKNHQKIHTREKPYRYRECDKSITKCSYLRTY------------------------ 403

  Fly   350 KRMAKEFQPVVKANETD-VYIAVNKLRRWLYDAIRRLKSKELIQKCSKQEVQYLQMCSFLPAKGS 413
            :|:....:| .:..|.| .:...:.||:.     :::.:.|....|...:..:|::.|.     .
  Rat   404 QRVHTGMRP-YRCTECDKSFTTYSNLRQH-----QKIHTGEKPPNCKGSDKSFLRISSV-----R 457

  Fly   414 ESQVLY-------CDYCDKRFHGDYNLRVHIVKAHEVGDLPYLCSFCPRRFDRHVDMDRHKLRSH 471
            :.|.::       |..|.:.|....||||| .:.| .|:.||.|..|.:.|....::..|:....
  Rat   458 KHQKIHAGERRYGCKECSRSFTWFSNLRVH-QRVH-TGERPYRCKDCDKSFTTGSNLRVHQKIHT 520

  Fly   472 FERKLKCQYCEKSFAVDTDLKVHTLIHTGERPHVCDICGKTF-RLKLLLDH---HV--------- 523
            .|:..||:.|:.||...::|:.|..|||||:|:.|..|.|:| |...|.||   |.
  Rat   521 GEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECKKSFTRCSYLRDHQKIHTGEKLYKCKD 585

  Fly   524 --------------NGVHLNIRPYSCNMCTKTFRKKFELANHIKGHLNIRDKKCEYCDATFYDHS 574
                          ..:|...:||.|..|.|:|.:...|.:|.|.|...:..||:.||.:|...|
  Rat   586 CNVSFMWISSLRRHQKIHTGEKPYKCRECEKSFTQCSTLRDHQKIHTGEKPYKCKDCDISFLWIS 650

  Fly   575 SLSRHRRSHRSE 586
            ||.||::.|..|
  Rat   651 SLRRHQKIHTGE 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1603	NP_001260778.1	MADF_DNA_bdg	202..287	CDD:287510	16/113 (14%)
		GT1	321..408	CDD:304916	12/87 (14%)
		C2H2 Zn finger	420..441	CDD:275368	8/20 (40%)
		COG5048	<424..583	CDD:227381	58/185 (31%)
		C2H2 Zn finger	450..471	CDD:275368	4/20 (20%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	490..513	CDD:290200	11/22 (50%)
		C2H2 Zn finger	506..527	CDD:275368	9/47 (19%)
		C2H2 Zn finger	535..555	CDD:275368	7/19 (37%)
		C2H2 Zn finger	563..583	CDD:275368	9/19 (47%)
Zfp52	NP_001014180.1	KRAB	44..84	CDD:396083
		C2H2 Zn finger	219..239	CDD:275368	3/19 (16%)
		SFP1	<241..324	CDD:227516	8/82 (10%)
		C2H2 Zn finger	247..295	CDD:275368	5/47 (11%)
		C2H2 Zn finger	303..323	CDD:275368	1/19 (5%)
		COG5048	329..702	CDD:227381	90/382 (24%)
		C2H2 Zn finger	331..351	CDD:275368	5/26 (19%)
		C2H2 Zn finger	359..379	CDD:275368	3/19 (16%)
		C2H2 Zn finger	388..407	CDD:275368	4/42 (10%)
		C2H2 Zn finger	415..435	CDD:275368	4/24 (17%)
		C2H2 Zn finger	443..463	CDD:275370	4/24 (17%)
		C2H2 Zn finger	471..491	CDD:275368	8/20 (40%)
		C2H2 Zn finger	499..519	CDD:275368	4/19 (21%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..575	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	0/19 (0%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	639..659	CDD:275368	9/19 (47%)
		C2H2 Zn finger	667..687	CDD:275368
		C2H2 Zn finger	695..715	CDD:275368
		zf-H2C2_2	707..730	CDD:404364
		C2H2 Zn finger	723..743	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000