DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1603 and CG1602

DIOPT Version :9

Sequence 1:	NP_001260778.1	Gene:	CG1603 / 35683	FlyBaseID:	FBgn0033185	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	193/596 - (32%)
Similarity:	301/596 - (50%)	Gaps:	79/596 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELCGNVMTNSKYEMFRLKCLYCSIESELKDWELFIVHVKSAHYCEDEDVRINEIKEDTEELYSV 65
            ||.||.:..:..||.|.::|.||..:.|:..|:.|::|:::.|    ..||..|
  Fly     1 METCGLICVSRDYEKFLMRCSYCPTDVEVAQWQEFVLHIRNVH----SKVRSME----------- 50

  Fly    66 VDAADPAIAYGPDEFFEVIENS------NGVDQWMEADSKDIQYEEDATAWSAATNNSWEFGPGG 124
                        |:|..|.|||      :..::..:|:....|.:|.|               .|
  Fly    51 ------------DDFEPVGENSTESGHVDPPEEKPQAEESIFQQDESA---------------DG 88

  Fly   125 SSLELPAGKEVTQMDESSQNHIPLNTDDDDVDCSDFFMSEDDLAPPRKPGRPPRRTRPGQVFKFK 189
            :.::|......:..:|:.::.:.|.||:::      .:.::|   |.:|.......:....:||.
  Fly    89 ACVQLHIDAVRSSTNETEESDVSLVTDEEE------SVQDED---PSEPALDDANLKTTPTYKFH 144

  Fly   190 VSFIRSNPRVLHLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERM--DRKANVLFTVEE--L 250
            .||.|.:.|.:..|:.||||||||||:...|: ||.:.   :..::||  |.:|.|...:.|  |
  Fly   145 PSFFRRDHRTIKFIEIYKEHPCLWNPAHSDYK-EPKKC---KEALKRMAIDLEATVSVFLNEMAL 205

  Fly   251 KKTLEQLHVQYTLALETKQRGKL--VGLAARYFAKCEFLSVAPVVTPRENEEDNDLTAIKLNFKE 313
            |..::::|:|:....:....||.  ..||...:..|.||:.:   ...|...:|:  .|||:|.:
  Fly   206 KLAIKKVHMQFNTVHKRVVSGKQKPQSLAFSIYKLCCFLNAS---NDEEGATNNE--KIKLDFSK 265

  Fly   314 ENLITTSFIETYANYPVLYNQALPDFGSIEIRADAFKRMAKEFQ-PVVKANETDVYIAVNKLRRW 377
            :|.:||..||.|||:|.||:....:|.::..|..|::.||.|.. |.|..|..|::.|:..||:|
  Fly   266 KNKLTTDLIEMYANFPQLYDSNHKEFSNMSSRKQAYESMAAEISVPNVDINSDDIFRAIQNLRQW 330

  Fly   378 LYDAIRRLKSKELIQKCSKQEVQYLQMCSFLPAKGSESQVLYCDYCDKRFHGDYNLRVHIVKAHE 442
            .|.     .:|..|...|..|..||::|.|:||| ...|.|.|::|.:....|:.|:.||.|||.
  Fly   331 YYK-----NTKHAIYAGSTAEKFYLEVCRFMPAK-MYKQRLVCEFCHQITSSDHVLQSHIFKAHN 389

  Fly   443 VGDLPYLCSFCPRRFDRHVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLIHTGERPHVCD 507
            :|:||:.|:.|.|.|....::..|..|.|..:..||.:||:||||.:||::|...|||.:|:||:
  Fly   390 IGELPFKCTLCDRSFVGRCELANHIQRVHIGKTHKCTHCERSFAVMSDLQLHIRTHTGHKPYVCE 454

  Fly   508 ICGKTFRLKLLLDHHVNGVHLNIRPYSCNMCTKTFRKKFELANHIKGHLNIRDKKCEYCDATFYD 572
            .|||.|||:..:..||..:|..||.:.|.||.|.|.||.:|::|||||||||||.|..|...|..
  Fly   455 HCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPKDFVKKVDLSDHIKGHLNIRDKICSVCGKGFTS 519

  Fly   573 HSSLSRHRRSH 583
            ..:|.|||:.|
  Fly   520 CHALIRHRQIH 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1603	NP_001260778.1	MADF_DNA_bdg	202..287	CDD:287510	29/90 (32%)
		GT1	321..408	CDD:304916	30/87 (34%)
		C2H2 Zn finger	420..441	CDD:275368	7/20 (35%)
		COG5048	<424..583	CDD:227381	71/158 (45%)
		C2H2 Zn finger	450..471	CDD:275368	6/20 (30%)
		C2H2 Zn finger	478..498	CDD:275368	10/19 (53%)
		zf-H2C2_2	490..513	CDD:290200	12/22 (55%)
		C2H2 Zn finger	506..527	CDD:275368	9/20 (45%)
		C2H2 Zn finger	535..555	CDD:275368	11/19 (58%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
CG1602	NP_610291.2	GT1	157..244	CDD:304916	29/90 (32%)
		MADF_DNA_bdg	273..356	CDD:287510	30/87 (34%)
		C2H2 Zn finger	367..388	CDD:275368	7/20 (35%)
		C2H2 Zn finger	397..418	CDD:275368	6/20 (30%)
		COG5048	<423..554	CDD:227381	55/108 (51%)
		C2H2 Zn finger	425..445	CDD:275368	10/19 (53%)
		zf-H2C2_2	437..460	CDD:290200	12/22 (55%)
		C2H2 Zn finger	453..470	CDD:275368	7/16 (44%)
		C2H2 Zn finger	482..502	CDD:275368	11/19 (58%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		C2H2 Zn finger	538..559	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C61I
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I3519
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012671
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860