DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1603 and Zfp980

DIOPT Version :9

Sequence 1:	NP_001260778.1	Gene:	CG1603 / 35683	FlyBaseID:	FBgn0033185	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001096628.2	Gene:	Zfp980 / 100041379	MGIID:	3712454	Length:	645	Species:	Mus musculus

Alignment Length:	621	Identity:	143/621 - (23%)
Similarity:	221/621 - (35%)	Gaps:	189/621 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FRLKCLYCSIESELKDWELFIV-HVKSAHYCEDEDVRINEIKEDTE-----------------EL 62
            |..:.||..:..|..:..||:. |....:| |.|.|    :::||:                 ||
Mouse    47 FAQRTLYMDVMLENYNNLLFVENHCICGNY-EKEKV----LEQDTQHIVNEHGHNRKKSSKCNEL 106

  Fly    63 YSVVDAADPAIAYGPDEFFEVIENSNGVDQWMEADSKDIQYEEDATAWSAATNNSWEFGPGGSSL 127
            .:|:..:..:..|..:.....:::|| :.:.....:|::...:|..       |..:   |.|.:
Mouse   107 RNVIHESSESTPYNTNHRDATLQSSN-LKRHKTGTTKEVCTYKDCV-------NCLK---GSSII 160

  Fly   128 ELPAGKEVTQ--------MDE---SSQNHIPLNTDDDDVDCSDF---FMSEDDLAPPRKPGRPPR 178
            .|..|..:.:        :||   |.||:..::|    ..|.:|   |...|:|       :..:
Mouse   161 SLNQGTHIEKKEHNRNKNLDEVLVSRQNNSEMST----YTCGEFDKCFTQSDNL-------QSQQ 214

  Fly   179 RTRPGQVFKFKVSFIRSNPRVLHLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANV 243
            |..||     |.|:|            |.|       ||:
Mouse   215 RIYPG-----KKSYI------------YSE-------SDK------------------------- 230

  Fly   244 LFTVEELKKTLEQLHVQYTLALETKQRGKLVGLAARYFAKCEFLSVAPVVTPRENEEDNDLTAIK 308
            .||      .|..|.:.:|:....|.            .||             :|.|...|. |
Mouse   231 CFT------QLSHLSIHHTIHSGEKP------------YKC-------------SECDKCFTD-K 263

  Fly   309 LNFKEENLITTSFIETYANYPVLYNQ---ALPDFGSIEIRADAFKRMAKEFQPVVKANETD---- 366
            ...::...|.|      ...|...|:   ...|.||:.:.    :|:....:| .|.:|.|
Mouse   264 FTLRKHQRIHT------GEKPYKCNECDKCFTDKGSLRVH----QRIHTGEKP-YKCSECDKCFT 317

  Fly   367 --VYIAVNKLRRWLYDAIRRLKSKELIQKCSKQEVQYLQMCSFLPAK--GSESQVLYCDYCDKRF 427
              .:::::          ||:.|.|...|||:.:..:....|....:  .:..:...|..|||.|
Mouse   318 QPSHLSIH----------RRIHSGEKPYKCSECDKCFTDKSSLRVHQRIHTGEKPYQCSECDKCF 372

  Fly   428 HGDYNLRVHIVKAHEV--GDLPYLCSFCPRRFDRHVDMDRHKLRSHF-----ERKLKCQYCEKSF 485
            ....:||||    |.:  |:.||.||.|.:.|     .|:..||.|.     |:..||..|:|.|
Mouse   373 TDKGSLRVH----HRIHAGEKPYQCSECDKCF-----TDKGSLRVHHRIHAGEKPYKCSECDKCF 428

  Fly   486 AVDTDLKVHTLIHTGERPHVCDICGKTFRLKLLLDHHVNGVHLNIRPYSCNMCTKTFRKKFELAN 550
            .....|:||..||.||:|:.|..|.|.|..|..|..| ..:|...:||.|:.|.|.|..|..|..
Mouse   429 THKDSLRVHHRIHAGEKPYKCSECDKCFTEKNGLRRH-QRIHTGEKPYKCSECDKCFTDKSSLRV 492

  Fly   551 HIKGHLNIRDKKCEYCDATFYDHSSLSRHRRSHRSE 586
            |.:.|...:..:|..||..|.|..||..|.|.|..|
Mouse   493 HQRIHTGEKPYQCSECDKCFTDKGSLRVHHRIHAGE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1603	NP_001260778.1	MADF_DNA_bdg	202..287	CDD:287510	12/84 (14%)
		GT1	321..408	CDD:304916	18/95 (19%)
		C2H2 Zn finger	420..441	CDD:275368	9/20 (45%)
		COG5048	<424..583	CDD:227381	60/165 (36%)
		C2H2 Zn finger	450..471	CDD:275368	7/20 (35%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..513	CDD:290200	11/22 (50%)
		C2H2 Zn finger	506..527	CDD:275368	7/20 (35%)
		C2H2 Zn finger	535..555	CDD:275368	7/19 (37%)
		C2H2 Zn finger	563..583	CDD:275368	9/19 (47%)
Zfp980	NP_001096628.2	KRAB	28..>70	CDD:214630	6/22 (27%)
		KRAB	28..67	CDD:279668	5/19 (26%)
		COG5048	96..510	CDD:227381	121/547 (22%)
		C2H2 Zn finger	197..217	CDD:275368	6/26 (23%)
		C2H2 Zn finger	229..245	CDD:275368	6/46 (13%)
		C2H2 Zn finger	253..273	CDD:275368	5/33 (15%)
		zf-H2C2_2	266..289	CDD:290200	4/28 (14%)
		C2H2 Zn finger	281..301	CDD:275368	5/23 (22%)
		zf-H2C2_2	293..318	CDD:290200	6/29 (21%)
		C2H2 Zn finger	309..329	CDD:275368	4/29 (14%)
		C2H2 Zn finger	337..357	CDD:275368	3/19 (16%)
		zf-H2C2_2	349..373	CDD:290200	5/23 (22%)
		C2H2 Zn finger	365..385	CDD:275368	10/23 (43%)
		C2H2 Zn finger	393..413	CDD:275368	8/24 (33%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	7/20 (35%)
		zf-H2C2_2	462..485	CDD:290200	8/23 (35%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		zf-H2C2_2	489..513	CDD:290200	6/23 (26%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	589..609	CDD:275368
		zf-H2C2_2	602..626	CDD:290200
		C2H2 Zn finger	617..634	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000