Protein Alignment az2 and ZNF160

DIOPT Version :10

• Sequence 1: NP_610289.2
• Gene: az2 / 35682
• FlyBaseID: FBgn0025185
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: XP_047295573.1
• Gene: ZNF160 / 90338
• HGNCID: 12948
• Length: 837
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 136/586 - (23%)
• Similarity: 209/586 - (35%)
• Gaps: 149/586 - (25%)

  Fly    53 QQELTTSEVISSAKCEEEVSP-AKVFIVEEPPENCLAEDMFVDVPPSSENDESTSPVEEEEEED- 115
            :::.:|..|..:...|...|| .:.|..:||.:|  ..|........:.|.:.....::|.:.|
Human   123 KEKSSTEAVFHTVVLERHESPDIEDFSFKEPQKN--VHDFECQWRDDTGNYKGVLMAQKEGKRDQ 185

  Fly   116 -DEVDSSSMTVDCELGTRNSTHFAPLTKF-----------------NPTFYRRSPRITQFIELYK 162
             |..|..:..::.:||....:|...|..|                 |.:......:|...::.::
Human   186 RDRRDIENKLMNNQLGVSFHSHLPELQLFQGEGKMYECNQVEKSTNNGSSVSPLQQIPSSVQTHR 250

  Fly   163 QQTCLWDPADESYRDKEKRANAYEELLEQLKA----------------TVNLHLTA--------- 202
            .:             |....|.:..|.::.||                |.|.:||:
Human   251 SK-------------KYHELNHFSLLTQRRKANSCGKPYKCNECGKAFTQNSNLTSHRRIHSGEK 302

  Fly   203 -YKLKKC--------ITSLHAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSD-DVD 257
             ||..:|        ..::|....:..:..|..:..||  :.|.  |:||....:...:.. ..:
Human   303 PYKCSECGKTFTVRSNLTIHQVIHTGEKPYKCHECGKV--FRHN--SYLATHRRIHTGEKPYKCN 363

  Fly   258 GDGKIKLVFTEENQLTTQFIDLYSKFPQLYDPAHKHF-CNLNVRKSSLIEITDLLTSEFSLGLVT 321
            ..||   .|...:.|||.         ||.....|.| ||         |...|.|.  :..|::
Human   364 ECGK---AFRGHSNLTTH---------QLIHTGEKPFKCN---------ECGKLFTQ--NSHLIS 405

  Fly   322 HYDVYDSIQSMRQWYSRRIKTLTDVQCVGLSLAEKQYIERCNSFMPTKSFRQKL----------- 375
            |:               ||.|           .||.|  :||......|.|..|
Human   406 HW---------------RIHT-----------GEKPY--KCNECGKAFSVRSSLAIHQTIHTGEK 442

  Fly   376 --KCEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCE 437
              ||..|...|..:..|..|: |.| .|:.. ::|..|...|....:|..| |.:|. .|.|.|.
Human   443 PYKCNECGKVFRYNSYLGRHR-RVH-TGEKP-YKCNECGKAFSMHSNLATH-QVIHTGTKPFKCN 503

  Fly   438 ICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKD 502
            .||:.|...:|||.|:|.|..:   ||:.|..|||.|..:..:||| .|:|:..:.:||..|.|.
Human   504 ECSKVFTQNSQLANHRRIHTGE---KPYKCNECGKAFSVRSSLTTH-QAIHSGEKPYKCIECGKS 564

  Fly   503 FLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKTLQCSLCTTRFSERVSLGV 566
            |..|..|:.|...|...:...|..|.|.|...:.|.:|..:|. ||..:|:.|...||:|.||..
Human   565 FTQKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTF 629

  Fly   567 H 567
            |
Human   630 H 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:463144	18/118 (15%)
		MADF_DNA_bdg	276..>341	CDD:463144	12/65 (18%)
		C2H2 Zn finger	377..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..429	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..488	CDD:275368	9/20 (45%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	551..572	CDD:275368	8/17 (47%)
ZNF160	XP_047295573.1	KRAB	27..87	CDD:214630
		SFP1	<235..351	CDD:227516	21/132 (16%)
		C2H2 Zn finger	278..298	CDD:275368	4/19 (21%)
		zf-H2C2_2	290..314	CDD:463886	5/23 (22%)
		C2H2 Zn finger	306..326	CDD:275368	2/19 (11%)
		C2H2 Zn finger	334..354	CDD:275368	6/23 (26%)
		zf-H2C2_2	346..369	CDD:463886	4/25 (16%)
		C2H2 Zn finger	362..382	CDD:275368	8/31 (26%)
		COG5048	386..829	CDD:227381	86/292 (29%)
		C2H2 Zn finger	390..410	CDD:275368	8/45 (18%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		C2H2 Zn finger	446..466	CDD:275368	6/20 (30%)
		C2H2 Zn finger	474..494	CDD:275368	6/20 (30%)
		C2H2 Zn finger	502..522	CDD:275368	9/19 (47%)
		C2H2 Zn finger	530..550	CDD:275368	9/20 (45%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..606	CDD:275368	6/19 (32%)
		C2H2 Zn finger	614..634	CDD:275368	8/17 (47%)
		C2H2 Zn finger	642..662	CDD:275368
		C2H2 Zn finger	670..690	CDD:275368
		C2H2 Zn finger	698..718	CDD:275368
		C2H2 Zn finger	726..746	CDD:275368
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	782..802	CDD:275368
		C2H2 Zn finger	810..830	CDD:275368