DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment az2 and ZNF347

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	539	Identity:	130/539 - (24%)
Similarity:	196/539 - (36%)	Gaps:	148/539 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LTKFNPTFYRRSPRITQFIELYKQQTCLWDPAD---------ESYRDKEKRAN------AYEELL 189
            ||:...||...:...:|     ::.||| |||.         |:||:....|.      :...:|
Human     3 LTQGQVTFRDVAIEFSQ-----EEWTCL-DPAQRTLYRDVMLENYRNLASLAGISCFDLSIISML 61

  Fly   190 EQLKATVNLHLTAY---------KLKKCITSLHAQY-------------------ASISRQ---- 222
            ||.|....|.....         .:|..||:|.:::                   ..:.||
Human    62 EQGKEPFTLESQVQIAGNPDGWEWIKAVITALSSEFVMKDLLHKGKSNTGEVFQTVMLERQESQD 126

  Fly   223 ------KKTQKLTKVPLYY----HGKYS--FLAERGSLEDADSDDVDGDGKIKLVFTEENQLTTQ 275
                  ::.||.|....|.    .|.|.  .|.:.|:|.....:....|.:.||:   :|||.
Human   127 IEGCSFREVQKNTHGLEYQCRDAEGNYKGVLLTQEGNLTHGRDEHDKRDARNKLI---KNQLG-- 186

  Fly   276 FIDLYSKFP--QLYDPAHKHF-CNLNVRKSSLIEITDLLTSEFSLGLVTHY------DVYDSI-- 329
             :.|.|..|  ||:....|.: || .|.||.....:.....:....:.||.      |...|:
Human   187 -LSLQSHLPELQLFQYEGKIYECN-QVEKSFNNNSSVSPPQQMPYNVKTHISKKYLKDFISSLLL 249

  Fly   330 ---QSMRQWYS--------------------RRIKTLTDVQCVGLSLAEKQYIERCNSFMPTKSF 371
               |....|.|                    :|..|           .||.|  :|  :...|:|
Human   250 TQGQKANNWGSPYKSNGCGMVFPQNSHLASHQRSHT-----------KEKPY--KC--YECGKAF 299

  Fly   372 R---------------QKLKCEVCEHSFSTDHALQAHQFRDHKMGDGGW-FRCTLCELNFDRKCH 420
            |               ::.||..|...||.:..|..||    |:..|.. ::|..|...|.:..|
Human   300 RTRSNLTTHQVIHTGEKRYKCNECGKVFSRNSQLSQHQ----KIHTGEKPYKCNECGKVFTQNSH 360

  Fly   421 LQQHSQRVHM-DKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHV 484
            |.:| :.:|. :|.:.|..|.::|...:.||||:.||..:   ||:.|..|||.|.|...:|.|
Human   361 LVRH-RGIHTGEKPYKCNECGKAFRARSSLAIHQATHSGE---KPYKCNECGKVFTQNSHLTNH- 420

  Fly   485 TAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKT 548
            ..:||..:.:||:.|.|.|..:..|..|:..|...:...|..|.|.|...:.|.:|:.||. ||.
Human   421 WRIHTGEKPYKCNECGKAFGVRSSLAIHLVIHTGEKPYKCHECGKVFRRNSHLARHQLIHTGEKP 485

  Fly   549 LQCSLCTTRFSERVSLGVH 567
            .:|:.|...|....:|..|
Human   486 YKCNECGKAFRAHSNLTTH 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	27/143 (19%)
		GT1	276..>341	CDD:304916	19/98 (19%)
		C2H2 Zn finger	377..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..429	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	8/20 (40%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	551..572	CDD:275368	5/17 (29%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630	17/64 (27%)
		KRAB	8..47	CDD:279668	12/44 (27%)
		C2H2 Zn finger	265..284	CDD:275368	1/18 (6%)
		COG5048	273..728	CDD:227381	71/256 (28%)
		zf-H2C2_2	276..301	CDD:290200	8/39 (21%)
		C2H2 Zn finger	292..312	CDD:275368	4/21 (19%)
		zf-H2C2_2	304..329	CDD:290200	4/24 (17%)
		C2H2 Zn finger	320..340	CDD:275368	8/23 (35%)
		zf-H2C2_2	333..357	CDD:290200	8/27 (30%)
		C2H2 Zn finger	348..368	CDD:275368	6/20 (30%)
		zf-H2C2_2	360..383	CDD:290200	7/23 (30%)
		C2H2 Zn finger	376..396	CDD:275368	7/19 (37%)
		zf-H2C2_2	388..413	CDD:290200	13/27 (48%)
		C2H2 Zn finger	404..424	CDD:275368	8/20 (40%)
		zf-H2C2_2	416..439	CDD:290200	8/23 (35%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		zf-H2C2_2	444..469	CDD:290200	7/24 (29%)
		zf-C2H2	458..480	CDD:278523	6/21 (29%)
		C2H2 Zn finger	460..480	CDD:275368	6/19 (32%)
		zf-H2C2_2	472..495	CDD:290200	8/22 (36%)
		C2H2 Zn finger	488..508	CDD:275368	5/17 (29%)
		zf-H2C2_2	500..525	CDD:290200	2/5 (40%)
		C2H2 Zn finger	516..536	CDD:275368
		zf-H2C2_2	528..552	CDD:290200
		C2H2 Zn finger	544..564	CDD:275368
		zf-H2C2_2	556..581	CDD:290200
		C2H2 Zn finger	572..592	CDD:275368
		zf-H2C2_2	584..609	CDD:290200
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	628..648	CDD:275368
		zf-H2C2_2	640..665	CDD:290200
		C2H2 Zn finger	656..676	CDD:275368
		zf-H2C2_2	668..693	CDD:290200
		C2H2 Zn finger	684..704	CDD:275368
		zf-H2C2_2	697..720	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		COG5048	723..>817	CDD:227381
		zf-H2C2_2	724..749	CDD:290200
		C2H2 Zn finger	740..760	CDD:275368
		zf-H2C2_2	752..777	CDD:290200
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	795..813	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840