DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and ZNF665

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	501	Identity:	132/501 - (26%)
Similarity:	191/501 - (38%)	Gaps:	125/501 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 IELYKQQ-TCLWDPADES-YRDKEKRANAYEELLEQLKATVNLHLTAYKLKKCI-TSL------- 212
            ||..::: ||| |||.:: |||         .:||..:..|:|.::.    ||: |.|
Human    43 IEFSQEEWTCL-DPAQKTLYRD---------VMLENYRNLVSLDISC----KCVNTDLPPKGKNN 93

  Fly   213 --HAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFT-------- 267
              .|.|        |.||.::........||...:.:..|.:....|.:|..|.|..
Human    94 MGEAFY--------TVKLERLESCDTVGLSFQEVQKNTYDFECQWKDDEGNYKTVLMLQKENLPG 150

  Fly   268 --------------EENQLTTQFIDLYSKFPQLYDPAHKHFCNLNVRKSSLIEITDLLTSEFSLG 318
                          .||||...|   .|..|:|....|         :..:.|...:..|..:.|
Human   151 RRAQRDRRAAGNRHIENQLGVSF---QSHLPELQQFQH---------EGKIYEYNQVEKSPNNRG 203

  Fly   319 LVTHY--DVYDSI--QSMRQWYSRRIKTLTDVQCVGLSLAEKQYIERCNSFMPTKSFRQKL---- 375
              .||  |....:  |:.|....:||.|           .||.|  :||......:.|..|
Human   204 --KHYKCDECGKVFSQNSRLTSHKRIHT-----------GEKPY--QCNKCGKAFTVRSNLTIHQ 253

  Fly   376 ---------KCEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM- 430
                     ||..|...||....|..|| |.| .|:.. ::|..|...|.....|..| |.:|.
Human   254 VIHTGEKPYKCNECGKVFSQPSNLAGHQ-RIH-TGEKP-YKCNECGKAFRAHSKLTTH-QVIHTG 314

  Fly   431 DKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFK 495
            :|.:.|:.|.:.|...:.||.|:|.|..:   ||:.|..|||.|..:..:|||.| :||..:.:|
Human   315 EKPYKCKECGKCFTQNSHLASHRRIHTGE---KPYKCNECGKAFSVRSSLTTHQT-IHTGEKPYK 375

  Fly   496 CDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKTLQCSLCTTRFS 559
            |:.|.|.|.....|..|.:.|...:...|..|.|||:..:.|.||:.||. ||..:|:.|...|:
Human   376 CNECGKVFRHNSYLAKHRRIHTGEKPYKCNECGKAFSMHSNLTKHQIIHTGEKPFKCNECVKVFT 440

  Fly   560 ERVSLGVHMRRTHK--------------ILKSSLSSSDALFTKTFP 591
            :...|..| ||.|.              .::|||::..|:.|...|
Human   441 QYSHLANH-RRIHTGEKPYRCDECGKAFSVRSSLTTHQAIHTGEKP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	25/95 (26%)
		GT1	276..>341	CDD:304916	14/68 (21%)
		C2H2 Zn finger	377..398	CDD:275368	8/20 (40%)
		C2H2 Zn finger	408..429	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	9/20 (45%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	551..572	CDD:275368	7/20 (35%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490	14/42 (33%)
		COG5048	192..580	CDD:227381	91/318 (29%)
		C2H2 Zn finger	208..228	CDD:275368	4/19 (21%)
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		C2H2 Zn finger	264..284	CDD:275368	8/20 (40%)
		C2H2 Zn finger	292..312	CDD:275368	6/20 (30%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		C2H2 Zn finger	348..368	CDD:275368	9/20 (45%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368	7/20 (35%)
		C2H2 Zn finger	460..480	CDD:275368	4/19 (21%)
		C2H2 Zn finger	488..508	CDD:275368
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	544..564	CDD:275368
		C2H2 Zn finger	572..592	CDD:275368
		zf-H2C2_2	584..608	CDD:316026
		C2H2 Zn finger	600..620	CDD:275368
		zf-H2C2_2	612..637	CDD:316026
		C2H2 Zn finger	628..648	CDD:275368
		zf-H2C2_2	640..664	CDD:316026
		C2H2 Zn finger	656..676	CDD:275368
		zf-H2C2_2	669..693	CDD:316026
		C2H2 Zn finger	684..704	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930