DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment az2 and ZNF184

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	235	Identity:	74/235 - (31%)
Similarity:	102/235 - (43%)	Gaps:	38/235 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 PTKSFRQKLKCEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM- 430
            |.|. .:..||..|..:||...||..|| |.| .|:.. ::|..||..|.|..:|..| ||:|.
Human   215 PVKK-EKSCKCNECGKAFSYCSALIRHQ-RTH-TGEKP-YKCNECEKAFSRSENLINH-QRIHTG 274

  Fly   431 DKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHV----------- 484
            ||.:.|:.|.:.|..|..|..|:|.|..:   ||:.|:.|||.|.|:..:..|.
Human   275 DKPYKCDQCGKGFIEGPSLTQHQRIHTGE---KPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTC 336

  Fly   485 ----------------TAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTN 533
                            ..:||..:.||||.|.|.|.....|..|.|.|...:...|..|.|||..
Human   337 NECGKAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNG 401

  Fly   534 ANALVKHRHIHK-EKTLQCSLCTTRFSERVSLGVHMRRTH 572
            .:..::|..||. ||..:|:.|...||:..:|..| ::||
Human   402 PSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQH-QKTH 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510
		GT1	276..>341	CDD:304916
		C2H2 Zn finger	377..398	CDD:275368	9/20 (45%)
		C2H2 Zn finger	408..429	CDD:275368	9/20 (45%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	7/47 (15%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	551..572	CDD:275368	6/20 (30%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630
		KRAB	28..67	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212
		C2H2 Zn finger	224..244	CDD:275368	9/20 (45%)
		zf-H2C2_2	236..261	CDD:290200	11/27 (41%)
		COG5048	<248..409	CDD:227381	47/165 (28%)
		C2H2 Zn finger	252..272	CDD:275368	9/20 (45%)
		zf-H2C2_2	264..287	CDD:290200	9/23 (39%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		zf-H2C2_2	292..317	CDD:290200	11/27 (41%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		zf-H2C2_2	320..345	CDD:290200	1/24 (4%)
		C2H2 Zn finger	336..356	CDD:275368	0/19 (0%)
		zf-H2C2_2	348..373	CDD:290200	9/24 (38%)
		COG5048	360..736	CDD:227381	29/82 (35%)
		C2H2 Zn finger	364..384	CDD:275368	8/19 (42%)
		zf-H2C2_2	376..400	CDD:290200	8/23 (35%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		zf-C2H2	418..440	CDD:278523	6/22 (27%)
		C2H2 Zn finger	420..440	CDD:275368	6/20 (30%)
		zf-H2C2_2	432..457	CDD:290200	4/10 (40%)
		C2H2 Zn finger	448..468	CDD:275368
		zf-H2C2_2	460..485	CDD:290200
		C2H2 Zn finger	476..496	CDD:275368
		zf-H2C2_2	488..513	CDD:290200
		C2H2 Zn finger	504..524	CDD:275368
		zf-H2C2_2	516..541	CDD:290200
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
		zf-H2C2_2	628..653	CDD:290200
		C2H2 Zn finger	644..664	CDD:275368
		zf-H2C2_2	656..681	CDD:290200
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	684..709	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930