DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and ZNF133

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001374224.1	Gene:	ZNF133 / 7692	HGNCID:	12917	Length:	691	Species:	Homo sapiens

Alignment Length:	255	Identity:	80/255 - (31%)
Similarity:	110/255 - (43%)	Gaps:	46/255 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 RRIKTL--TDVQC--VGLSLA--------------EKQYIERCNSFMPTKSFRQKLKCEVCEHSF 384
            :||:.|  ..|.|  .|||.:              ||.|:                 |.|||..|
Human   241 KRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYV-----------------CGVCEKGF 288

  Fly   385 STDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCEICSRSFAFGNQ 448
            |...:|..|| :.|. |:.. ..|..|...|:||..|..| :|.|. :|.::|..|.|.|:..:.
Human   289 SLKKSLARHQ-KAHS-GEKP-IVCRECGRGFNRKSTLIIH-ERTHSGEKPYMCSECGRGFSQKSN 349

  Fly   449 LAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHV 513
            |.||:|||..:   ||:||..|||.|.||..:..| ...|.:.:...|..|...|..:.:|..|.
Human   350 LIIHQRTHSGE---KPYVCRECGKGFSQKSAVVRH-QRTHLEEKTIVCSDCGLGFSDRSNLISHQ 410

  Fly   514 KAHLNIRDKVCEVCQKAFTNANALVKHRHIH-KEKTLQCSLCTTRFSERVSLGVHMRRTH 572
            :.|...:...|:.|.:.|.....||.|:..| |||...|.:|...||:..:|..| ||||
Human   411 RTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISH-RRTH 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510
		GT1	276..>341	CDD:304916	1/2 (50%)
		C2H2 Zn finger	377..398	CDD:275368	9/20 (45%)
		C2H2 Zn finger	408..429	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..488	CDD:275368	8/20 (40%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	551..572	CDD:275368	8/20 (40%)
ZNF133	NP_001374224.1	KRAB	1..60	CDD:214630
		COG5048	252..661	CDD:227381	76/244 (31%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		C2H2 Zn finger	281..301	CDD:275368	9/20 (45%)
		C2H2 Zn finger	309..329	CDD:275368	8/20 (40%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	8/20 (40%)
		C2H2 Zn finger	393..413	CDD:275368	5/19 (26%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..469	CDD:275368	8/20 (40%)
		C2H2 Zn finger	477..497	CDD:275368
		C2H2 Zn finger	505..525	CDD:275368
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	589..609	CDD:275368
		C2H2 Zn finger	617..637	CDD:275368
		C2H2 Zn finger	645..664	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000