DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and ZNF84

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	347	Identity:	98/347 - (28%)
Similarity:	150/347 - (43%)	Gaps:	65/347 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 FTEENQLTTQFIDLYSKFPQLYDPAHKHFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVYDSIQ 330
            |:.::||.|.........|.......|.|    ..||.||....:.|.|      ..|:..:..:
Human   356 FSRKSQLVTHHRTHTGTKPFGCSDCRKAF----FEKSELIRHQTIHTGE------KPYECSECRK 410

  Fly   331 SMRQWYS--RRIKTLTD------VQCVGLSLAEKQYI---------------ERCNSFMPTKSFR 372
            :.|:..|  ...:|.|.      :|| |.:.::|.::               .:|.     |:|.
Human   411 AFRERSSLINHQRTHTGEKPHGCIQC-GKAFSQKSHLISHQMTHTGEKPFICSKCG-----KAFS 469

  Fly   373 QK---------------LKCEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQ 422
            :|               .:|..|..:||...:|..|| |.| .|:..:. |:.|...|.:|.||.
Human   470 RKSQLVRHQRTHTGEKPYECSECGKAFSEKLSLTNHQ-RIH-TGEKPYV-CSECGKAFCQKSHLI 531

  Fly   423 QHSQRVHM-DKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTA 486
            .| ||.|. :|.:.|..|.::|...:.||.|:|||..:   ||:.|..|.|.|.||.|:.|| ..
Human   532 SH-QRTHTGEKPYECSECGKAFGEKSSLATHQRTHTGE---KPYECRDCEKAFSQKSQLNTH-QR 591

  Fly   487 VHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKTLQ 550
            :||..:.::|.:|.|.|..|.:|..|::.|...:...|..|:|||...::|:.|:.||. ||..:
Human   592 IHTGEKPYECSLCRKAFFEKSELIRHLRTHTGEKPYECNECRKAFREKSSLINHQRIHTGEKPFE 656

  Fly   551 CSLCTTRFSERVSLGVHMRRTH 572
            ||.|...||.:..|..| :|||
Human   657 CSECGKAFSRKSHLIPH-QRTH 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510
		GT1	276..>341	CDD:304916	12/66 (18%)
		C2H2 Zn finger	377..398	CDD:275368	8/20 (40%)
		C2H2 Zn finger	408..429	CDD:275368	9/20 (45%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	9/20 (45%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..572	CDD:275368	8/20 (40%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368
		C2H2 Zn finger	237..257	CDD:275368
		C2H2 Zn finger	265..285	CDD:275368
		zf-H2C2_2	278..302	CDD:316026
		C2H2 Zn finger	293..313	CDD:275368
		COG5048	317..724	CDD:227381	98/347 (28%)
		C2H2 Zn finger	321..341	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368	4/12 (33%)
		C2H2 Zn finger	377..397	CDD:275368	6/23 (26%)
		C2H2 Zn finger	405..425	CDD:275368	2/19 (11%)
		C2H2 Zn finger	433..453	CDD:275368	4/20 (20%)
		C2H2 Zn finger	461..481	CDD:275368	4/24 (17%)
		C2H2 Zn finger	489..509	CDD:275368	8/20 (40%)
		C2H2 Zn finger	517..537	CDD:275368	9/20 (45%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	9/20 (45%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
		C2H2 Zn finger	629..649	CDD:275368	7/19 (37%)
		C2H2 Zn finger	657..677	CDD:275368	8/20 (40%)
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840