DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and ZNF302

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_016882467.1	Gene:	ZNF302 / 55900	HGNCID:	13848	Length:	444	Species:	Homo sapiens

Alignment Length:	509	Identity:	112/509 - (22%)
Similarity:	183/509 - (35%)	Gaps:	129/509 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PENCLAEDMFVDVPPSSENDESTSPVEEEEEEDDEVDSSSMTVDCELGTRNSTHFAPLTKFNPTF 147
            |..||..:..|:...:.|.......:|.|.....:|..|.:.:|..
Human    13 PNGCLVSNCGVNKMSNEELVGQNHGMEGEACTGGDVTFSDVAIDFS------------------- 58

  Fly   148 YRRSPRITQFIELYKQQTCLWDPADESYRD--KEKRANAYEELLEQLKATVNLHLTAYKLKKCIT 210
                         :::..||    |.:.||  |:.....||.|:    :...|.:|
Human    59 -------------HEEWACL----DSAQRDLYKDVMVQNYENLV----SVAGLSVT--------- 93

  Fly   211 SLHAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEENQLTTQ 275
                            |...:.|...||..::.|:...:|.:|.            .|..:|:|:
Human    94 ----------------KPYVIMLLEDGKEPWMMEKKLSKDWESR------------WENKELSTK 130

  Fly   276 FIDLY---SKFPQLYDPAHK---HFCNLNVRKSSLIEIT--DLLTSEF-------------SLGL 319
             .|:|   |..|...:...|   .|.|.|..    :|.|  |...|.|             :.|.
Human   131 -KDIYDEDSPQPVTMEKVVKQSYEFSNSNKN----LEYTECDTFRSTFHSKSTLSEPQNNSAEGN 190

  Fly   320 VTHYDVYDSIQSMRQWY-SRRI---KTLTDVQCVGLSLAEKQYI---ERCNSFMPTKSFRQKL-K 376
            ...||:.....|.:... |.||   |.|.:....|.:..:.:.:   :.||        |:|: .
Human   191 SHKYDILKKNLSKKSVIKSERINGGKKLLNSNKSGAAFNQSKSLTLPQTCN--------REKIYT 247

  Fly   377 CEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHMDKSFVCEICSR 441
            |..|..:|.....|..| :|.| .|:.. :.|..|...|.....|.:|......:|.:.|..|.:
Human   248 CSECGKAFGKQSILSRH-WRIH-TGEKP-YECRECGKTFSHGSSLTRHQISHSGEKPYKCIECGK 309

  Fly   442 SFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTK 506
            :|:.|:.|..|:.||..:   ||:.|..|||.|.:...:..|: .:||:.:.::|.:|.|.|:..
Human   310 AFSHGSSLTNHQSTHTGE---KPYECMNCGKSFSRVSLLIQHL-RIHTQEKRYECRICGKAFIHS 370

  Fly   507 RDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKTLQCSLCTTRFS 559
            ..|..|.|:|...:...|..|.|||..::.|.:|:.||. :|..:|:.|...||
Human   371 SSLIHHQKSHTGEKPYECRECGKAFCCSSHLTQHQRIHSMKKKYECNKCLKVFS 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	15/86 (17%)
		GT1	276..>341	CDD:304916	20/89 (22%)
		C2H2 Zn finger	377..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..429	CDD:275368	5/20 (25%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..488	CDD:275368	6/20 (30%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..572	CDD:275368	4/9 (44%)
ZNF302	XP_016882467.1	KRAB	48..109	CDD:214630	18/125 (14%)
		COG5048	<151..393	CDD:227381	64/260 (25%)
		C2H2 Zn finger	248..268	CDD:275368	6/20 (30%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	332..352	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142432
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930