DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and ZNF107

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	499	Identity:	120/499 - (24%)
Similarity:	183/499 - (36%)	Gaps:	132/499 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 DKEKRANAYEELLEQLKATVNLHLTAYKLKK--CITSLHAQYASISRQKKTQK------------ 227
            ||...:|.|:.     :.|.|.|....:..|  |:.|...|:..|..:..:.|
Human   199 DKFSNSNRYKR-----RHTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNSYKCEECGKAFNWFS 258

  Fly   228 -LTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEE---------------NQLTTQF 276
             |||....:.|:..:..|........|..:.   :.|::.|||               :.||...
Human   259 TLTKHKRIHTGEKPYKCEECGKAFNQSSQLT---RHKIIHTEEKPNKCEECGKAFKQASHLTIHK 320

  Fly   277 IDLYSKFPQLYDPAHKHFCNLNVRKSSLIEITDLLTSE-----------FSL--GLVTHYDVYDS 328
            |....:.|..|:...|.|.    :.|.|.....|.|.|           |:|  .|..|
Human   321 IIHTGEKPYKYEECGKVFS----QSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNH------ 375

  Fly   329 IQSMRQWYSRRIKTLTDVQCVGLSLAEKQY-IERCNSFMPTKSFRQKL----------KCEVCEH 382
                     :||..           .||.| .:.|.......|...|.          |||.|:.
Human   376 ---------KRIHA-----------GEKPYKCKECGRAFNISSNLNKQEKIHTGGKLNKCEECDK 420

  Fly   383 SFSTDHALQAH--------------------QFRD---HKMGDGGW--FRCTLCELNFDRKCHLQ 422
            :|:....|.||                    ||..   ||:...|.  ::|..|...|::..:|.
Human   421 AFNRSLKLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKCKECGKAFNQSSNLT 485

  Fly   423 QHSQRVH-MDKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTA 486
            :| :::| .:||:.||.|.::|...:.|..|::.:..:   ||:.||.|||.|.:...:|.| ..
Human   486 EH-KKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGE---KPYKCEECGKAFNRSSTLTRH-KK 545

  Fly   487 VHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKTLQ 550
            :||..:.:||:.|.:.|....:|.:|.|.|...:...||.|.|||...:.|.||:.||. ||..:
Human   546 IHTGEKPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKCEECGKAFNRFSTLTKHKRIHTGEKPYK 610

  Fly   551 CSLCTTRFSERVSLGVHMRRTHKIL--KSSLSSSDALFTKTFPQ 592
            |..|...|::...|     ..|||:  |..|:..:. |.|.|.|
Human   611 CEECGKAFNQSYQL-----TRHKIVHTKEKLNKCEE-FGKAFKQ 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	17/79 (22%)
		GT1	276..>341	CDD:304916	15/77 (19%)
		C2H2 Zn finger	377..398	CDD:275368	9/43 (21%)
		C2H2 Zn finger	408..429	CDD:275368	5/20 (25%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..488	CDD:275368	8/20 (40%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		C2H2 Zn finger	551..572	CDD:275368	4/20 (20%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	4/16 (25%)
		C2H2 Zn finger	219..239	CDD:275368	4/19 (21%)
		COG5048	243..621	CDD:227381	98/415 (24%)
		C2H2 Zn finger	247..267	CDD:275368	3/19 (16%)
		C2H2 Zn finger	275..295	CDD:275368	3/22 (14%)
		C2H2 Zn finger	303..323	CDD:275368	3/19 (16%)
		C2H2 Zn finger	331..351	CDD:275368	5/23 (22%)
		C2H2 Zn finger	359..379	CDD:275368	5/34 (15%)
		C2H2 Zn finger	387..407	CDD:275368	3/19 (16%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	443..463	CDD:275368	4/19 (21%)
		C2H2 Zn finger	471..491	CDD:275368	5/20 (25%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	8/20 (40%)
		COG5048	551..>863	CDD:227381	34/104 (33%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		C2H2 Zn finger	611..631	CDD:275368	7/24 (29%)
		C2H2 Zn finger	639..659	CDD:275368	4/11 (36%)
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142206
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930