Protein Alignment az2 and ZNF710

DIOPT Version :10

• Sequence 1: NP_610289.2
• Gene: az2 / 35682
• FlyBaseID: FBgn0025185
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: XP_047288438.1
• Gene: ZNF710 / 374655
• HGNCID: 25352
• Length: 702
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 131/581 - (22%)
• Similarity: 212/581 - (36%)
• Gaps: 159/581 - (27%)

  Fly   109 EEEEEEDDEVDSSSMTVDCELGTRNST----HFAPLTKFNPTFYRRSPRITQFIELYKQQTCLWD 169
            |..|||..||:::     ||..||..|    ...|..||........       |:|:...
Human   101 EPAEEEVLEVEAA-----CEKHTRRKTRPPVRLVPKVKFEKVEEEEQ-------EVYEVSV---- 149

  Fly   170 PADESYRDKE--------KRANAYEELLEQLKATVNLHLTAYKLKKCITSLHAQYASISRQKKTQ 226
            |.|    ||:        :.|:...:.|.|..|...:.|:|:. :|..|..|     :.|..:.:
Human   150 PGD----DKDAGPAEAPAEAASGGCDALVQSSAVKMIDLSAFS-RKPRTLRH-----LPRTPRPE 204

  Fly   227 KLTKVPLYYH-----------------GKYSFLAERG-------SLEDADSDDVDGDGKIK---- 263
             |...|...|                 |..:...|.|       .|.|.::..::....:|
Human   205 -LNVAPYDPHFPAPARDGFPEPSMALPGPEALPTECGFEPPHLAPLSDPEAPSMESPEPVKPEQG 268

  Fly   264 LVFTEENQLTTQFIDLYSKFPQLYDPAHKHFCNLNVR--KSSLIEITD------------LLTSE 314
            .|:.|.::...   |......:.:..|.....::||:  .|.|:|..|            ..||:
Human   269 FVWQEASEFEA---DTAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSK 330

  Fly   315 FSLGLVTHYDVYDSIQSMRQWYSRRIKTLTDVQCVGLSLAEKQYIERCNSFMPTKSFRQKLKCEV 379
            ::  ||||...::.|:..              .|...|...|| .....:.:.|....:..||:|
Human   331 YN--LVTHILGHNGIKPH--------------SCPHCSKLFKQ-PSHLQTHLLTHQGTRPHKCQV 378

  Fly   380 CEHSFS-TDH---------------------------ALQAH----------------------- 393
            |..:|: |.|                           .|:||
Human   379 CHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLT 443

  Fly   394 QFRDHKMGDGG--WFRCTLCELNFDRKCHLQQHSQRVHMDKSFVCEICSRSFAFGNQLAIHKRTH 456
            |.:.|.....|  .::|..|:.:|..:..||.|..:....:.|||..|...|:..:.|..|..||
Human   444 QLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTH 508

  Fly   457 DEKHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRD 521
              |.| |.|.||.||:.|..:..|..|: .:||.:|.::|.:|.|.|:.|:.||.|:..|..::.
Human   509 --KGV-KEFKCEVCGREFTLQANMKRHM-LIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKP 569

  Fly   522 KVCEVCQKAFTNANALVKHRHIHK-EKTLQCSLCTTRFSERVSLGVHMRRTHKILKSSLSS 581
            ..|:||.|:|.....|:.|.|:|. .|..:|..|:::|:.:.:|..||:..|.::...|.|
Human   570 FKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDS 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:463144	20/109 (18%)
		MADF_DNA_bdg	276..>341	CDD:463144	15/78 (19%)
		C2H2 Zn finger	377..398	CDD:275368	10/71 (14%)
		C2H2 Zn finger	408..429	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..488	CDD:275368	7/20 (35%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	551..572	CDD:275368	6/20 (30%)
ZNF710	XP_047288438.1	C2H2 Zn finger	320..340	CDD:275368	6/21 (29%)
		C2H2 Zn finger	348..368	CDD:275368	4/20 (20%)
		COG5048	<358..616	CDD:227381	66/261 (25%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		C2H2 Zn finger	404..424	CDD:275368	3/19 (16%)
		C2H2 Zn finger	432..452	CDD:275368	2/19 (11%)
		C2H2 Zn finger	460..480	CDD:275368	6/19 (32%)
		C2H2 Zn finger	488..508	CDD:275368	5/19 (26%)
		C2H2 Zn finger	516..536	CDD:275368	7/20 (35%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		C2H2 Zn finger	600..619	CDD:275368	6/18 (33%)