DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment az2 and CG12942

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_610628.2	Gene:	CG12942 / 36158	FlyBaseID:	FBgn0033569	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	135/640 - (21%)
Similarity:	216/640 - (33%)	Gaps:	211/640 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EFIVH-VKEHLEANPSMQQELTTSEVIS-----SAKCEEEVSPAKVFIVE-----EPPENCLAED 90
            |..:| |:..||:|..:|.|..:.::.|     ..|...|..|...|..|     |..|..:.|:
  Fly    83 EVAMHFVEMALESNLKLQAEAKSVKLPSPTGELKRKASNETIPWNQFSQEFEQFVEGYEGPIEEN 147

  Fly    91 MF---------VDVPPSSENDESTSPVEEEE------------EEDDEVDSSSMTVDCELGTRNS 134
            :.         :||..||.::  |:|.|:|.            ||:||.|.|.       ...|.
  Fly   148 VLYMRGTKVPRLDVDASSSSE--TAPKEDEVILFDVKYDTNDLEEEDENDGSD-------AKNNE 203

  Fly   135 THF------------------APLTKFNPTFYRRSPRIT----QFIELYKQQT-----CLWDPAD 172
            |.|                  |.....|..|..::..:|    ..|:...:.|     |...|.:
  Fly   204 TFFENSITPGESVMVVSVAEKAVENNNNYNFNNKNGDVTDEECDLIQRALEMTLNDDGCSQSPKN 268

  Fly   173 ESYRDKEKRANAYE-------ELLEQLKATVNL-----------HLTAYKLKKCITSLHAQYASI 219
            |:..:.:.::|..|       :|......|.|:           |..|.:||....|:|
  Fly   269 EASNETQLKSNGIEVSSPLFIKLATTSSTTGNIPILKCNICQYTHTDAEQLKIHYKSIH------ 327

  Fly   220 SRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEENQLTTQFIDLYSKFP 284
                              |.|.:          .||:.|..|        ||
  Fly   328 ------------------KISMM----------EDDIIGLNK--------NQ------------- 343

  Fly   285 QLYDPAHKHFCNLNVRKSSLIEITDLLTSEFSLGLVTH------YDVYDSIQ------------- 330
                       |...|..:..|..|  .||....|:.|      :::|..:|
  Fly   344 -----------NFKCRPCNSYETKD--RSEMQKHLIDHHKIDGDFEMYCYMQANCPACDRIFKDQ 395

  Fly   331 -SMRQWYSRRIKTLTDVQCVGLSLAEKQYIERCNSFMPTKSFRQKLKCEVCEHSFSTDHALQAHQ 394
             |.|:.|:|   ..|.|| :.:|              ||:|:    .|..|:..|:...:|.:||
  Fly   396 RSARKHYTR---VHTPVQ-IAVS--------------PTESY----ACTACDKVFNQKASLHSHQ 438

  Fly   395 FRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVH-MDKSFVCEICSRSFAFGNQLAIHKRTHDE 458
             |..::.|  ...|:.|:..|:.....:.|.|::| ::....||||.|||.....|.:|::.|.|
  Fly   439 -RFCQVKD--VVHCSFCDQQFNSMRKYELHLQQLHAVETVHECEICRRSFKSAETLTMHRKRHSE 500

  Fly   459 KHVAKPFVCEFCGKC---FKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDH-VKAHLNI 519
            :|..       ||||   :....::..|....|.......|..|...|.....|::| .::|...
  Fly   501 RHYQ-------CGKCSLNYVNSAELRVHYERAHVNEEPVSCLTCGNQFQNMTLLREHEQRSHQKS 558

  Fly   520 RDKVCEVCQKAFTNANALVKHRHIHKEKTLQCSLCTTRFSERVSLGVHMRRTHKI 574
            :...||||...........:|::.|.:...:|..||:.|::|.....|.::.|.|
  Fly   559 KVWRCEVCNFETKTRWRRRQHQYEHMDYPYKCQKCTSEFADRSKFRQHSKKVHGI 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	18/107 (17%)
		GT1	276..>341	CDD:304916	14/84 (17%)
		C2H2 Zn finger	377..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..429	CDD:275368	5/20 (25%)
		C2H2 Zn finger	436..456	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..488	CDD:275368	5/23 (22%)
		C2H2 Zn finger	496..516	CDD:275368	5/20 (25%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		C2H2 Zn finger	551..572	CDD:275368	6/20 (30%)
CG12942	NP_610628.2	zf-AD	22..101	CDD:285071	6/17 (35%)
		C2H2 Zn finger	385..406	CDD:275368	4/23 (17%)
		C2H2 Zn finger	421..470	CDD:275368	13/51 (25%)
		C2H2 Zn finger	449..466	CDD:275371	3/16 (19%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		C2H2 Zn finger	505..526	CDD:275368	5/20 (25%)
		C2H2 Zn finger	534..555	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930