DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and CG1603

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001260778.1	Gene:	CG1603 / 35683	FlyBaseID:	FBgn0033185	Length:	586	Species:	Drosophila melanogaster

Alignment Length:	604	Identity:	187/604 - (30%)
Similarity:	288/604 - (47%)	Gaps:	75/604 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVVCGNILARNNFEHFVLACAHQNDCYVEMEFKRWREFIVHVK-------EHLEANPSMQQELTT 58
            |.:|||::..:.:|.|.|.|.:   |.:|.|.|.|..||||||       |.:..|...:.....
  Fly     1 MELCGNVMTNSKYEMFRLKCLY---CSIESELKDWELFIVHVKSAHYCEDEDVRINEIKEDTEEL 62

  Fly    59 SEVISSAKCEEEVSPAKVFIVEEPPENCLAEDMF------------------------------- 92
            ..|:.:|.......|.:.|   |..||....|.:
  Fly    63 YSVVDAADPAIAYGPDEFF---EVIENSNGVDQWMEADSKDIQYEEDATAWSAATNNSWEFGPGG 124

  Fly    93 --VDVPPSSE---NDESTSPVEEEEEEDDEVDSSS--MTVDCELGTR------NSTHFAPLTKFN 144
              :::|...|   .|||:........:||:||.|.  |:.|.....|      ..|....:.||.
  Fly   125 SSLELPAGKEVTQMDESSQNHIPLNTDDDDVDCSDFFMSEDDLAPPRKPGRPPRRTRPGQVFKFK 189

  Fly   145 PTFYRRSPRITQFIELYKQQTCLWDPADESYRDKEKRANAYEELLEQLKATVNLHLTAYKLKKCI 209
            .:|.|.:||:...|:.||:..|||:|:||.|:|:..|:.|||.::|::....|:..|..:|||.:
  Fly   190 VSFIRSNPRVLHLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANVLFTVEELKKTL 254

  Fly   210 TSLHAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEENQLTT 274
            ..||.||......|:..||..:...|..|..||:....:...::::.:....|||.|.|||.:||
  Fly   255 EQLHVQYTLALETKQRGKLVGLAARYFAKCEFLSVAPVVTPRENEEDNDLTAIKLNFKEENLITT 319

  Fly   275 QFIDLYSKFPQLYDPAHKHFCNLNVRKSSLIEITDLLTSEFS-LGLVTHYDVYDSIQSMRQW-YS 337
            .||:.|:.:|.||:.|...|.::.:|..:.    ..:..||. :......|||.::..:|:| |.
  Fly   320 SFIETYANYPVLYNQALPDFGSIEIRADAF----KRMAKEFQPVVKANETDVYIAVNKLRRWLYD 380

  Fly   338 --RRIKTLTDVQ-CVGLSLAEKQYIERCNSFMPTK-SFRQKLKCEVCEHSFSTDHALQAHQFRDH 398
              ||:|:...:| |   |..|.||::.| ||:|.| |..|.|.|:.|:..|..|:.|:.|..:.|
  Fly   381 AIRRLKSKELIQKC---SKQEVQYLQMC-SFLPAKGSESQVLYCDYCDKRFHGDYNLRVHIVKAH 441

  Fly   399 KMGDGGWFRCTLCELNFDRKCHLQQHSQRVHMDKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAK 463
            ::||..:. |:.|...|||...:.:|..|.|.::...|:.|.:|||....|.:|...|..:   :
  Fly   442 EVGDLPYL-CSFCPRRFDRHVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLIHTGE---R 502

  Fly   464 PFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQ 528
            |.||:.|||.|:.|:.:..||..||..||.:.|:||.|.|..|.:|.:|:|.|||||||.||.|.
  Fly   503 PHVCDICGKTFRLKLLLDHHVNGVHLNIRPYSCNMCTKTFRKKFELANHIKGHLNIRDKKCEYCD 567

  Fly   529 KAFTNANALVKHRHIHKEK 547
            ..|.:.::|.:||..|:.:
  Fly   568 ATFYDHSSLSRHRRSHRSE 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	30/84 (36%)
		GT1	276..>341	CDD:304916	19/68 (28%)
		C2H2 Zn finger	377..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..429	CDD:275368	7/20 (35%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	8/20 (40%)
		C2H2 Zn finger	496..516	CDD:275368	9/19 (47%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..572	CDD:275368
CG1603	NP_001260778.1	MADF_DNA_bdg	202..287	CDD:287510	30/84 (36%)
		GT1	321..408	CDD:304916	28/94 (30%)
		C2H2 Zn finger	420..441	CDD:275368	6/20 (30%)
		COG5048	<424..583	CDD:227381	60/162 (37%)
		C2H2 Zn finger	450..471	CDD:275368	7/20 (35%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..513	CDD:290200	9/25 (36%)
		C2H2 Zn finger	506..527	CDD:275368	8/20 (40%)
		C2H2 Zn finger	535..555	CDD:275368	9/19 (47%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C61I
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I3519
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012671
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860