DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and zf30C

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster

Alignment Length:	605	Identity:	126/605 - (20%)
Similarity:	202/605 - (33%)	Gaps:	180/605 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VKEH-----LEANPSMQQELTTSEVISSAKCEEEV---SPAKVFIVEEPPENCLAEDMFVDVPPS 98
            :|:|     .:.|.....|.||||  .|...::::   |..|..:.:| .:|..:.|...|..|:
  Fly   172 MKKHKAFRKKDRNRDSDDEDTTSE--ESEDSDDDIPLASRLKTKLKQE-SQNSDSGDECPDFEPN 233

  Fly    99 SENDESTS-----------PVEEEEEEDDEVDSSSMTVDCE------------------------ 128
            :..|::.:           .||..:|||.|...:||.|..|
  Fly   234 NSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLK 298

  Fly   129 ----------LGTRNSTHFAPLTKF-----------------NPTFYRRSP--RITQFIELYKQQ 164
                      .|..:.....||.:.                 .|....|.|  :|......|:::
  Fly   299 PFESLKVEQGAGILDEIAAVPLVEVAEEDVLELRGHQMEKPPGPRKRGRPPKEKIPVVKRKYRKR 363

  Fly   165 TCLWDPA--DESYRDKEKRANAYEELLEQLKATVNLHLTAYKLKKCITSLHAQYASISRQKKTQK 227
            .....|:  |.|...|.....:.:||.|:|| .:|....::|...|:...|
  Fly   364 NAPRSPSPDDSSGTPKRVAKISKKELKERLK-MINKMEKSWKCPHCVKIYH-------------- 413

  Fly   228 LTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEENQLTTQFIDLYSKFPQLYDPAHK 292
             .:.|...|     |.:...|.:|:..::..|                 :|:::|   |.:...|
  Fly   414 -IRKPYEKH-----LRDDHKLNEAEMKEIFKD-----------------VDVHAK---LDEEVFK 452

  Fly   293 HFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVY--DSIQSMRQWYSRRIKTLTDVQCVGLSLAE 355
              |.: ..|..|:|          ..||||..|:  |.            |......|.
  Fly   453 --CPI-CSKIYLVE----------KRLVTHMKVHGEDG------------KLTFKCPCY------ 486

  Fly   356 KQYIERCNSFMPTK---------SFRQKLKCEVCEHSFSTDHALQAHQFRDHKMGDGGWFR---- 407
                  ||.|..||         ..::.|.||.|:...:...:|:.|:...|...:....:
  Fly   487 ------CNLFFATKEQATEHARAQHKELLYCEKCDKYMTGHDSLKNHERNFHSKKEPRSQQRNLI 545

  Fly   408 CTLCELNFDRKCHLQQHSQRVHMD----KSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCE 468
            |..|...|..:..|..|   |..|    ..:.|.:|.:..:....|..|...|   ....|:.|:
  Fly   546 CDKCGKKFTGRTSLSDH---VRSDCGRLPLYGCSVCGKHLSTAGILKTHMLLH---KADTPYQCD 604

  Fly   469 FCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTN 533
            .|||.||.|.|..:|:...||..:.:||.:|||::..:..|..|:..|..|:..:|..|.|.||.
  Fly   605 KCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTC 669

  Fly   534 ANALVKHRHIHKEKTLQCSL 553
            .:.|..||.:|.:...|..|
  Fly   670 ISNLQAHRKVHADTCGQLPL 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	16/86 (19%)
		GT1	276..>341	CDD:304916	14/66 (21%)
		C2H2 Zn finger	377..398	CDD:275368	5/20 (25%)
		C2H2 Zn finger	408..429	CDD:275368	5/20 (25%)
		C2H2 Zn finger	436..456	CDD:275368	4/19 (21%)
		C2H2 Zn finger	467..488	CDD:275368	9/20 (45%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	551..572	CDD:275368	1/3 (33%)
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368
		C2H2 Zn finger	98..117	CDD:275368
		C2H2 Zn finger	134..152	CDD:275368
		C2H2 Zn finger	511..532	CDD:275370	5/20 (25%)
		COG5048	<523..>672	CDD:227381	41/154 (27%)
		C2H2 Zn finger	546..566	CDD:275368	6/22 (27%)
		C2H2 Zn finger	575..595	CDD:275368	4/19 (21%)
		C2H2 Zn finger	603..624	CDD:275368	9/20 (45%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030