Protein Alignment az2 and ZNF181

DIOPT Version :9

• Sequence 1: NP_610289.2
• Gene: az2 / 35682
• FlyBaseID: FBgn0025185
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: XP_016882229.1
• Gene: ZNF181 / 339318
• HGNCID: 12971
• Length: 585
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 128/608 - (21%)
• Similarity: 215/608 - (35%)
• Gaps: 172/608 - (28%)

  Fly    24 NDCYVEMEFKRWREFIVHVKEHLEANPSMQQ-ELTTSEVISSAKCEEEVSPAKVFIVEEPPENCL 87
            ||..::...:.| .::...:..|..:..:|. |...|..:|..|      |..:.::|:..|..:
Human    26 NDVAIDFTHEEW-GWLSSAQRDLYKDVMVQNYENLVSVGLSVTK------PYVITLLEDGKEPWM 83

  Fly    88 AE-DMFVDVPPSSENDESTSPVEEEEEEDDEVDSSSMTVDCELGTRNSTHFAPLTKFNPTFYRRS 151
            .| .:..|.....||.|.::      ::|:..:.|..||..|...:.|..|:           .|
Human    84 MEKKLSKDWESRWENKELST------KKDNYDEDSPQTVIIEKVVKQSYEFS-----------NS 131

  Fly   152 PRITQFIE----LYKQQTCLWDPADESYRDKEKRANAYEELLEQLKATVNLHLTAYKLKKCITSL 212
            .:..::||    .:..|...:.||..:.|:.....:.|:         .|:..:.:..|..:
Human   132 KKNLEYIEKLEGKHGSQVDHFRPAILTSRESPTADSVYK---------YNIFRSTFHSKSTL--- 184

  Fly   213 HAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLV--------FTEE 269
             ::...||.:..:.           ||..|.:....:....::....|| ||:        |::.
Human   185 -SEPQKISAEGNSH-----------KYDILKKNLPKKSVIKNEKVNGGK-KLLNSNKSGAAFSQG 236

  Fly   270 NQLTTQFIDLYSKFPQ------LYDPAHKHFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVYDS 328
            ..||         .||      :|..:.   |.....|.|::.
Human   237 KSLT---------LPQTCNREKIYTCSE---CGKAFGKQSILN---------------------- 267

  Fly   329 IQSMRQWYSRRIKTLTDVQCVGLSLAEKQYIERCNSFMPTKSFRQKL-------------KCEVC 380
                |.|   ||.|           .||.|  .|.....|.|....|             ||..|
Human   268 ----RHW---RIHT-----------GEKPY--ECRECGKTFSHGSSLTRHLISHSGEKPYKCIEC 312

  Fly   381 EHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVH-MDKSFVCEICSRSFA 444
            ..:||...:|..||  ....|:.. :.|..|..:|.|..||.:| .|:| .:|.:.|.||.::|.
Human   313 GKAFSHVSSLTNHQ--STHTGEKP-YECMNCGKSFSRVSHLIEH-LRIHTQEKLYECRICGKAFI 373

  Fly   445 FGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHV------------------------- 484
            ..:.|..|::.|..:   ||:.|..|||.|.....:|.|.
Human   374 HRSSLIHHQKIHTGE---KPYECRECGKAFCCSSHLTRHQRIHTMEKQYECNKCLKVFSSLSFLV 435

  Fly   485 --TAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-E 546
              .::||:.:.|:|..|.|.|.....|..|::.|:.::...|.:|.|||::.::|::|..||. |
Human   436 QHQSIHTEEKPFECQKCRKSFNQLESLNMHLRNHIRLKPYECSICGKAFSHRSSLLQHHRIHTGE 500

  Fly   547 KTLQCSLCTTRFSERVSLGVHMR 569
            |..:|..|...||...:|.||.|
Human   501 KPYECIKCGKTFSCSSNLTVHQR 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	13/88 (15%)
		GT1	276..>341	CDD:304916	9/70 (13%)
		C2H2 Zn finger	377..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..429	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..488	CDD:275368	7/47 (15%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..572	CDD:275368	8/19 (42%)
ZNF181	XP_016882229.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142427
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930