DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment az2 and CG8944

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	151/769 - (19%)
Similarity:	257/769 - (33%)	Gaps:	243/769 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CGNILARNNFEHFVLACAHQNDCYVEMEFKRWREFI-----VHVKEHLEANPSMQQELTTSEVIS 63
            ||.:.|.::|::|.|.|     .:...:|..:..||     ||:.:...||.|.:......|.:|
  Fly    22 CGMVTATDDFQYFALRC-----IFCSEKFLYFDSFIGHMQTVHLGDQSVANTSSRLPFNLGEPMS 81

  Fly    64 SAKCE---------EEVSPAKVFIVEEPPENCLAEDMFVDVPPS------SENDESTSPVEEEEE 113
            .:...         |:::.|...::|  |:..:.::: .|:|.|      .|.|:....:.:.|.
  Fly    82 LSGRNGDLPNFHEIEDLTDADTALLE--PQMVIKQEL-QDLPCSDDDVVAGEEDDDEQRLNDSEA 143

  Fly   114 EDDEV---DSSSMTVDCELGTR--------------------------------------NSTHF 137
            ::||.   :|....|..:...|                                      ||..:
  Fly   144 DEDEAILPESDVPVVSSKTRARKKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEY 208

  Fly   138 APLTKFN------------------------------PTFYRRSPRITQF-IELYKQQTCLWDPA 171
            .....|:                              .|.:.:..::.|| |..|::...|||..
  Fly   209 MDFAGFDGVNHSGFGTESDFLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDHG 273

  Fly   172 DESYRDKEKRANAYEELLEQLKATVNLHLTAYKLKKCITSLHAQYASISRQKKTQKLTKVPLYYH 236
            :..:||:.|||...:.::.:.|:..|:.|....:.:...:|...|.....:...:|.....|:|.
  Fly   274 NAQFRDRVKRARFLDWIVLEFKSRFNISLAKDAITRKWDNLRTVYKRECNRMALEKTNISTLWYF 338

  Fly   237 GKYSFLAERGSLEDADSDDVDGDGKIKLVFTE-ENQLTT----QFIDLYSKFPQLYDPAHK---- 292
            .:..||.|..|..|..||.|..:...:..|:. .|..:|    ..:..|..|...:||.::
  Fly   339 KELHFLNEVYSYNDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNRFDPDYRSKER 403

  Fly   293 -----HFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVYDSIQSMRQWYSRRIKTLTDVQCVGLS 352
                 |  .:.:....||::|.:..|:             .|..:|..||
  Fly   404 RGEGLH--QMAIELQQLIDVTTIQISK-------------RISQLRFDYS--------------- 438

  Fly   353 LAEKQYIERCNSFMPTKSFRQK----------------LKCEVCEHSFSTDHALQAHQFRDHKMG 401
               ||.:||.||....|.|...                .||..|.....|...|..|.. .|:..
  Fly   439 ---KQKMERLNSERLGKKFIANYLYYDQMHFMDDDIPPFKCAHCPEIVQTLRELDLHML-THQPS 499

  Fly   402 DGGWFRCTLCELNFDRKCHLQQHSQRVHM----DKSFVCEICSRSFAFGNQLAIHKRTHDE---- 458
            .||.:.|.:|.:.|........|.| :|:    :..|.||:|:.||........|.|.|:|
  Fly   500 LGGGYYCNICSIQFHNAQEFDNHKQ-LHLGGVTEIKFNCELCTASFREKANYDEHLRRHNEELFL 563

  Fly   459 -----------------------------------KH---------------------------- 460
                                               :|
  Fly   564 PSLALNHSIMEGGLGDDEIGVEGEESRGSGSRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGT 628

  Fly   461 -VAKPFVCEFCGKCFKQKIQMTTHVTAVH--TKIRAFKCD--MCPKDFLTKRDLKDHVKAHLNIR 520
             :|||:.|:.|.:.|.....:..| ..||  .:.|.:|||  .|.|.|:.:..|.:|:|.|.:..
  Fly   629 DIAKPYGCDVCRRSFATPGHLNAH-RIVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNE 692

  Fly   521 DKVCEVCQKAFTNANALVKHRHIH-KEKTLQCSLCTTRFSERVSLGVHMRRTHK 573
            :..|::|.|.|.:...|..|:.|| |.|...|.:|.:.|::...|.:|.||.::
  Fly   693 EFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLHKRRHNR 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	19/85 (22%)
		GT1	276..>341	CDD:304916	13/73 (18%)
		C2H2 Zn finger	377..398	CDD:275368	5/20 (25%)
		C2H2 Zn finger	408..429	CDD:275368	5/20 (25%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	4/20 (20%)
		C2H2 Zn finger	496..516	CDD:275368	8/21 (38%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	551..572	CDD:275368	7/20 (35%)
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	18/84 (21%)
		MADF	379..472	CDD:214738	21/125 (17%)
		C2H2 Zn finger	476..496	CDD:275368	5/20 (25%)
		C2H2 Zn finger	506..526	CDD:275368	5/20 (25%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	636..656	CDD:275368	4/20 (20%)
		zf-C2H2_8	639..712	CDD:292531	21/73 (29%)
		C2H2 Zn finger	666..688	CDD:275368	8/21 (38%)
		zf-C2H2	694..716	CDD:278523	6/21 (29%)
		C2H2 Zn finger	696..716	CDD:275368	6/19 (32%)
		zf-H2C2_2	708..733	CDD:290200	9/24 (38%)
		C2H2 Zn finger	724..744	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012671
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840