DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and CG43347

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001138185.2	Gene:	CG43347 / 31991	FlyBaseID:	FBgn0263072	Length:	2684	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	119/571 - (20%)
Similarity:	215/571 - (37%)	Gaps:	128/571 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VPPSSENDESTSP------VEEEEEEDDEVDSSSMTVDCELGTRNSTHFAPLTKFNPTFYRRSPR 153
            :||:|.::....|      .:|::::|:|:|..::.                         |..:
  Fly   874 MPPNSYDEHDDEPGAGLGGNDEDDDDDEELDEEALA-------------------------REMK 913

  Fly   154 ITQ-FIELYKQQTCLWDPADESYRDKEKRANAYEELLEQLK-----ATVNLHLTAYKLKKCITSL 212
            :.| |:|...:.    |.|..|::...:.:.|::..|..|:     .|..:.|..:..::.:.:|
  Fly   914 MEQNFVEEEDEH----DIAFRSHQSCRECSIAHDHKLCPLRNACGNVTDAVDLGEWIERRNLEAL 974

  Fly   213 HAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEENQLTT--- 274
            ....|...||.|...         |:...  |...:||.:..|:|.|...:|...|...|.|
  Fly   975 AKLKADAQRQAKRAS---------GRQRH--EDDDMEDMEDMDMDMDESSQLSELETKPLITFAE 1028

  Fly   275 -----QF-----------------IDLYSKF-PQLYDPAHK-------------HFCNLNVRKSS 303
                 :|                 :..::|. |.:..|...             ..|.....||.
  Fly  1029 ASVPAEFELHNVEPNVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEMCEAGADKSY 1093

  Fly   304 LIEITDLLTSEFSLGLVTHYDVYDS-----IQSMRQWYSRRIKTLTDVQCVGLSLAEKQYIERCN 363
            |:...:...|.: |..|.....|:.     :...||.|....:.|.:    |:.|.  .:.:.||
  Fly  1094 LLCCDNPNASNW-LRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRN----GMELL--YWSDDCN 1151

  Fly   364 SFMPTKSFRQKLKCEVCEHSFSTDHAL--QAH--QFRDHKMG-DGGWFRCTLCELNFDRKCHLQQ 423
            : |..|...:|..|..|...|  :|.|  :.|  .|.|..|. ....:.|.:|......|.::.:
  Fly  1152 T-MWRKKHTEKTNCGGCNLKF--EHPLYYRTHCSVFHDPSMSLTIRKYHCKVCGEPVLGKDNIMK 1213

  Fly   424 HSQRVHMDK-SFVCEICSRSFAFGNQLAIHKRTH---DEKHVAKPFVCEFCGKCFKQKIQMTTHV 484
            |:...|..| ::.|:.||:.|...|.|.:| ||:   ...:.::| ||:|||:.|.|..::..|:
  Fly  1214 HAAEKHDGKGAYQCQFCSKFFLRLNYLEMH-RTYGCASNPNRSRP-VCDFCGRKFCQPQKLKAHI 1276

  Fly   485 TAVHTK----IRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKV---CEVCQKAFTNANALVKHRH 542
            ..:|:.    :|.|:|.:|.|...::..|:.|.| .::.|:..   |..|||.|.|.:.|..|..
  Fly  1277 KRMHSDMAEVLRDFQCKLCSKLLGSRAALQRHSK-EVHSRNSTVVSCPRCQKLFQNRSNLKIHML 1340

  Fly   543 IHK-EKTLQCS--LCTTRFSERVSLGVHMRRTHKILKSSLSSSDALFTKTF 590
            .|. .:..:|:  .|...|:.:..|..|.::.|...:..:...:.....||
  Fly  1341 THSGVRPFKCAEPECNAAFTTKQCLQFHYKKVHNYTQEQMPKIERSVAYTF 1391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	16/89 (18%)
		GT1	276..>341	CDD:304916	15/100 (15%)
		C2H2 Zn finger	377..398	CDD:275368	7/24 (29%)
		C2H2 Zn finger	408..429	CDD:275368	4/20 (20%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..488	CDD:275368	7/20 (35%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	551..572	CDD:275368	5/22 (23%)
CG43347	NP_001138185.2	NR_DBD_like	1198..>1268	CDD:295381	22/71 (31%)
		C2H2 Zn finger	1198..1219	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1227..1255	CDD:275368	9/28 (32%)
		C2H2 Zn finger	1259..1280	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1292..1313	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1322..1342	CDD:275368	8/19 (42%)
		zf-H2C2_2	1334..1361	CDD:290200	6/26 (23%)
		C2H2 Zn finger	1350..1373	CDD:275368	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100