DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and Zfp764

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_666315.3	Gene:	Zfp764 / 233893	MGIID:	2443580	Length:	431	Species:	Mus musculus

Alignment Length:	210	Identity:	56/210 - (26%)
Similarity:	90/210 - (42%)	Gaps:	15/210 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 KCEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCEIC 439
            :|..|..||:....|.||.:.  ..|:.. |.|..|..:|.|...|..| :.:|. ::...|..|
Mouse   209 QCPDCGKSFTQRSTLVAHMYT--HTGEKP-FCCPDCNKSFSRSSSLSSH-RAIHRGERPHCCPDC 269

  Fly   440 SRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFL 504
            .|:|...:.|..|.|.|..:   ||:.|..||:||.|:.....|...||:.:..|.|..|.:.|.
Mouse   270 GRAFTRRSGLIAHLRIHTGE---KPYCCADCGRCFSQRSAFREHQRVVHSGVTPFTCTHCGRAFA 331

  Fly   505 TKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKTLQCSLCTTRFSERVSLGVHM 568
            ..:.|:.|::.|...:...|..|.:.|..::.:..||..|. |:...|..|..:|..:.::..|.
Mouse   332 DSKYLRRHMRIHTGEKPYSCPDCGRCFRQSSEIPAHRRTHTGERPYPCPQCGRQFRTKSAMTSHQ 396

  Fly   569 ------RRTHKILKS 577
                  .:.||..|:
Mouse   397 WVHRPGAKGHKDKKA 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510
		GT1	276..>341	CDD:304916
		C2H2 Zn finger	377..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..429	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	7/20 (35%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		C2H2 Zn finger	551..572	CDD:275368	4/26 (15%)
Zfp764	NP_666315.3	KRAB	22..81	CDD:214630
		KRAB	22..55	CDD:279668
		C2H2 Zn finger	154..174	CDD:275368
		zf-H2C2_2	167..191	CDD:290200
		COG5048	178..>243	CDD:227381	11/36 (31%)
		C2H2 Zn finger	182..202	CDD:275368
		zf-H2C2_2	194..219	CDD:290200	4/9 (44%)
		C2H2 Zn finger	210..230	CDD:275368	7/21 (33%)
		zf-H2C2_2	223..243	CDD:290200	7/22 (32%)
		COG5048	262..>317	CDD:227381	19/57 (33%)
		C2H2 Zn finger	266..286	CDD:275368	7/19 (37%)
		zf-H2C2_2	282..303	CDD:290200	10/23 (43%)
		zf-C2H2	321..343	CDD:278523	6/21 (29%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		zf-H2C2_2	335..360	CDD:290200	6/24 (25%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..388	CDD:290200	7/20 (35%)
		C2H2 Zn finger	379..399	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930