DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment az2 and Zfp553

DIOPT Version :9

Sequence 1:NP_610289.2 Gene:az2 / 35682 FlyBaseID:FBgn0025185 Length:593 Species:Drosophila melanogaster
Sequence 2:NP_001347841.1 Gene:Zfp553 / 233887 MGIID:2384725 Length:591 Species:Mus musculus


Alignment Length:268 Identity:74/268 - (27%)
Similarity:102/268 - (38%) Gaps:69/268 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   369 KSFRQ---------------KLKCEVCEHSFSTDHALQAHQFRDH----------------KM-- 400
            |||||               ..||.||...|....|...|| |.|                ||  
Mouse    90 KSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQ-RTHTGEKAYRVRPPAPGPPKMPR 153

  Fly   401 -----GDGGWFRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCEICSRSFAFGNQLAIHKRTH--D 457
                 |:.... |..|..:|.:...|.:| ||.|. :|.:.|.||.:.|...:....|:|||  |
Mouse   154 SRIPAGERPTI-CGECGKSFRQSSDLVKH-QRTHTGEKPYKCGICGKGFGDSSARIKHQRTHRGD 216

  Fly   458 E----------------------KHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCP 500
            :                      |...||::|..|||.|.....:.:|..: |...:.|.||:|.
Mouse   217 QLPRPVVPRRQPSPAAPAAPHRPKAQDKPYICTDCGKRFVLSCSLLSHQRS-HLGPKPFGCDVCG 280

  Fly   501 KDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKTLQCSLCTTRFSERVSL 564
            |:|....||..|::.|...:..:|..|.|.|.:::|.|||...|. ::...|..|...||...:|
Mouse   281 KEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGQRPHACPECNRSFSLSSTL 345

  Fly   565 GVHMRRTH 572
            ..| |.||
Mouse   346 LRH-RLTH 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
az2NP_610289.2 MADF_DNA_bdg 157..242 CDD:287510
GT1 276..>341 CDD:304916
C2H2 Zn finger 377..398 CDD:275368 8/20 (40%)
C2H2 Zn finger 408..429 CDD:275368 7/20 (35%)
C2H2 Zn finger 436..456 CDD:275368 6/19 (32%)
C2H2 Zn finger 467..488 CDD:275368 6/20 (30%)
C2H2 Zn finger 496..516 CDD:275368 8/19 (42%)
C2H2 Zn finger 524..544 CDD:275368 8/19 (42%)
C2H2 Zn finger 551..572 CDD:275368 7/20 (35%)
Zfp553NP_001347841.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..80
C2H2 Zn finger 85..105 CDD:275368 5/14 (36%)
zf-H2C2_2 97..120 CDD:316026 4/22 (18%)
C2H2 Zn finger 113..133 CDD:275368 8/20 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 131..160 4/28 (14%)
COG5048 161..572 CDD:227381 56/196 (29%)
C2H2 Zn finger 165..185 CDD:275368 7/20 (35%)
C2H2 Zn finger 193..213 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..241 5/34 (15%)
C2H2 Zn finger 248..268 CDD:275368 6/20 (30%)
C2H2 Zn finger 276..296 CDD:275368 8/19 (42%)
C2H2 Zn finger 304..324 CDD:275368 8/19 (42%)
C2H2 Zn finger 332..352 CDD:275368 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..429
C2H2 Zn finger 425..445 CDD:275368
C2H2 Zn finger 453..538 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 464..512
C2H2 Zn finger 546..566 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 564..591
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832296
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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