DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and ZNF785

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_011544054.1	Gene:	ZNF785 / 146540	HGNCID:	26496	Length:	418	Species:	Homo sapiens

Alignment Length:	271	Identity:	73/271 - (26%)
Similarity:	110/271 - (40%)	Gaps:	25/271 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 RIKTLTDVQCVGLSLAEKQY------IERCNS--------FMPTKSFRQKLKCEVCEHSFSTDHA 389
            |:|.....:.|...:|.|::      .|.||.        ...|.:.|....|..|..:||....
Human   135 RLKKCPKQKEVAHEVAVKEWWPSVACPEFCNPRQSPMNPWLKDTLTRRLPHSCPDCGRNFSYPSL 199

  Fly   390 LQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCEICSRSFAFGNQLAIHK 453
            |.:|| |.|. |:.. |.|..|:..|.::.:|.|| |.:|. :|.:.|..|.|.|.....||||:
Human   200 LASHQ-RVHS-GERP-FSCGQCQARFSQRRYLLQH-QFIHTGEKPYPCPDCGRRFRQRGSLAIHR 260

  Fly   454 RTHDEKHVAKPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLN 518
            |.|..:   ||:.|..|...|.....:..| ...||..:.:.|..|...|.....|..|.:.|..
Human   261 RAHTGE---KPYACSDCKSRFTYPYLLAIH-QRKHTGEKPYSCPDCSLRFAYTSLLAIHRRIHTG 321

  Fly   519 IRDKVCEVCQKAFTNANALVKHRHIHKE-KTLQCSLCTTRFSERVSLGVHMRRTHKILKSSLSSS 582
            .:...|..|.:.||.::.|:.||.||.: :...|..|...|..:.:|..| |..|:......:..
Human   322 EKPYPCPDCGRRFTYSSLLLSHRRIHSDSRPFPCVECGKGFKRKTALEAH-RWIHRSCSERRAWQ 385

  Fly   583 DALFTKTFPQP 593
            .|:..::.|.|
Human   386 QAVVGRSEPIP 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510
		GT1	276..>341	CDD:304916	1/1 (100%)
		C2H2 Zn finger	377..398	CDD:275368	8/20 (40%)
		C2H2 Zn finger	408..429	CDD:275368	7/20 (35%)
		C2H2 Zn finger	436..456	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..488	CDD:275368	4/20 (20%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..572	CDD:275368	6/20 (30%)
ZNF785	XP_011544054.1	KRAB	29..102	CDD:214630
		COG5048	<156..372	CDD:227381	63/224 (28%)
		C2H2 Zn finger	187..207	CDD:275368	8/20 (40%)
		C2H2 Zn finger	215..235	CDD:275368	7/20 (35%)
		C2H2 Zn finger	243..263	CDD:275368	9/19 (47%)
		C2H2 Zn finger	271..291	CDD:275368	4/20 (20%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		C2H2 Zn finger	355..375	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930