DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment az2 and Zfp980

DIOPT Version :9

Sequence 1:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001096628.2	Gene:	Zfp980 / 100041379	MGIID:	3712454	Length:	645	Species:	Mus musculus

Alignment Length:	452	Identity:	114/452 - (25%)
Similarity:	174/452 - (38%)	Gaps:	90/452 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 PADESYRDKEKRANAYEELLEQLKATVNLHLTAYKLKKCITSL------------HAQYASISRQ 222
            |.:.::||    |......|::.|......:..|  |.|:..|            |.:....:|.
Mouse   118 PYNTNHRD----ATLQSSNLKRHKTGTTKEVCTY--KDCVNCLKGSSIISLNQGTHIEKKEHNRN 176

  Fly   223 KKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEENQLTTQFIDLYSKFPQLY 287
            |...::             |..|.:..:..:...   |:....||:.:.|.:|......|...:|
Mouse   177 KNLDEV-------------LVSRQNNSEMSTYTC---GEFDKCFTQSDNLQSQQRIYPGKKSYIY 225

  Fly   288 DPAHKHFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVYDSIQSMRQWY--SRRIKTLTDVQCV- 349
            ..:.|.|..|                       :|..::.:|.|..:.|  |...|..||...:
Mouse   226 SESDKCFTQL-----------------------SHLSIHHTIHSGEKPYKCSECDKCFTDKFTLR 267

  Fly   350 ---GLSLAEKQYIERCNS----FMPTKSFR--QKL-------KCEVCEHSFSTDHALQAHQFRDH 398
               .:...||.|  :||.    |....|.|  |::       ||..|:..|:....|..|: |.|
Mouse   268 KHQRIHTGEKPY--KCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQPSHLSIHR-RIH 329

  Fly   399 KMGDGGWFRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCEICSRSFAFGNQLAIHKRTHDEKHVA 462
            . |:.. ::|:.|:..|..|..|:.| ||:|. :|.:.|..|.:.|.....|.:|.|.|..:
Mouse   330 S-GEKP-YKCSECDKCFTDKSSLRVH-QRIHTGEKPYQCSECDKCFTDKGSLRVHHRIHAGE--- 388

  Fly   463 KPFVCEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVC 527
            ||:.|..|.|||..|..:..| ..:|...:.:||..|.|.|..|..|:.|.:.|...:...|..|
Mouse   389 KPYQCSECDKCFTDKGSLRVH-HRIHAGEKPYKCSECDKCFTHKDSLRVHHRIHAGEKPYKCSEC 452

  Fly   528 QKAFTNANALVKHRHIHK-EKTLQCSLCTTRFSERVSLGVHMRRTHKILKS-SLSSSDALFT 587
            .|.||..|.|.:|:.||. ||..:||.|...|:::.||.|| :|.|...|. ..|..|..||
Mouse   453 DKCFTEKNGLRRHQRIHTGEKPYKCSECDKCFTDKSSLRVH-QRIHTGEKPYQCSECDKCFT 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	13/83 (16%)
		GT1	276..>341	CDD:304916	10/66 (15%)
		C2H2 Zn finger	377..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..429	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..488	CDD:275368	7/20 (35%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	551..572	CDD:275368	9/20 (45%)
Zfp980	NP_001096628.2	KRAB	28..>70	CDD:214630
		KRAB	28..67	CDD:279668
		COG5048	96..510	CDD:227381	111/447 (25%)
		C2H2 Zn finger	197..217	CDD:275368	5/22 (23%)
		C2H2 Zn finger	229..245	CDD:275368	4/38 (11%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		zf-H2C2_2	266..289	CDD:290200	5/24 (21%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..318	CDD:290200	7/24 (29%)
		C2H2 Zn finger	309..329	CDD:275368	6/20 (30%)
		C2H2 Zn finger	337..357	CDD:275368	8/20 (40%)
		zf-H2C2_2	349..373	CDD:290200	8/24 (33%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	7/20 (35%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		zf-H2C2_2	462..485	CDD:290200	9/22 (41%)
		C2H2 Zn finger	477..497	CDD:275368	9/20 (45%)
		zf-H2C2_2	489..513	CDD:290200	9/24 (38%)
		C2H2 Zn finger	505..525	CDD:275368	4/9 (44%)
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	589..609	CDD:275368
		zf-H2C2_2	602..626	CDD:290200
		C2H2 Zn finger	617..634	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000